| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 1,036,679 | 1,028,049 | -8,630 | 0.34 | 0.18 | -0.16 | sell |
| Nantahala Capital Management, LLC | 900,000 | 995,000 | +95,000 | 0.60 | 0.35 | -0.24 | buy |
| ORBIMED ADVISORS LLC | 967,000 | 967,000 | 0 | 0.19 | 0.12 | -0.06 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 967,000 | 932,973 | -34,027 | 0.13 | 0.08 | -0.05 | sell |
| Affinity Asset Advisors, LLC | 657,154 | 607,872 | -49,282 | 0.82 | 0.45 | -0.38 | sell |
| Deep Track Capital, LP | 859,876 | 567,103 | -292,773 | 0.22 | 0.09 | -0.13 | sell |
| Commodore Capital LP | 483,000 | 483,000 | 0 | 0.29 | 0.17 | -0.11 | hold |
| TCG Crossover Management, LLC | 483,000 | 483,000 | 0 | 0.53 | 0.28 | -0.25 | hold |
| BANK OF AMERICA CORP /DE/ | 0 | 406,571 | +406,571 | 0.00 | 0.00 | +0.00 | buy |
| RWA WEALTH PARTNERS, LLC | 312,779 | 261,016 | -51,763 | 0.03 | 0.02 | -0.02 | sell |
| VANGUARD GROUP INC | 166,941 | 166,941 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BlackRock, Inc. | 133,726 | 155,899 | +22,173 | 0.00 | 0.00 | -0.00 | buy |
| Velan Capital Investment Management LP | 111,972 | 154,972 | +43,000 | 0.92 | 0.77 | -0.15 | buy |
| PERCEPTIVE ADVISORS LLC | 520,000 | 139,667 | -380,333 | 0.15 | 0.03 | -0.12 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 107,812 | 110,460 | +2,648 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 10,000 | 104,730 | +94,730 | 0.02 | 0.08 | +0.07 | buy |
| UBS Group AG | 98,951 | 83,724 | -15,227 | 0.00 | 0.00 | -0.00 | sell |
| Sio Capital Management, LLC | 71,458 | 72,173 | +715 | 0.17 | 0.14 | -0.03 | buy |
| Ikarian Capital, LLC | 200,000 | 35,300 | -164,700 | 0.52 | 0.06 | -0.46 | sell |
| NORTHERN TRUST CORP | 22,673 | 22,673 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Walleye Capital LLC | 20,223 | 20,613 | +390 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 12,889 | +12,889 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 11,321 | +11,321 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 10,976 | +10,976 | 0.00 | 0.00 | +0.00 | buy |
| Allostery Investments LP | 107,141 | 9,000 | -98,141 | 1.24 | 0.57 | -0.67 | sell |
| SBI Securities Co., Ltd. | 22 | 22 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 4 | 5 | +1 | 0.00 | 0.00 | -0.00 | buy |
| Avion Wealth | 5 | 5 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Parallel Advisors, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Key FInancial Inc | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Activest Wealth Management | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 2 | 1 | -1 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 10,289 | 0 | -10,289 | 0.00 | 0.00 | -0.00 | sell |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |