| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 2,879,481 | 5,100,216 | +2,220,735 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 327,082 | 4,365,553 | +4,038,471 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 0 | 3,610,000 | +3,610,000 | 0.00 | 0.98 | +0.98 | buy |
| Caligan Partners LP | 1,635,023 | 3,163,866 | +1,528,843 | 1.73 | 2.82 | +1.09 | buy |
| TCG Crossover Management, LLC | 738,383 | 3,017,120 | +2,278,737 | 0.32 | 1.34 | +1.02 | buy |
| Affinity Asset Advisors, LLC | 1,340,840 | 2,900,000 | +1,559,160 | 1.17 | 2.62 | +1.45 | buy |
| STATE STREET CORP | 71,654 | 2,889,287 | +2,817,633 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 916,000 | 2,498,000 | +1,582,000 | 0.08 | 0.27 | +0.19 | buy |
| Point72 Asset Management, L.P. | 916,142 | 2,387,026 | +1,470,884 | 0.02 | 0.07 | +0.04 | buy |
| Avoro Capital Advisors LLC | 1,410,000 | 2,333,333 | +923,333 | 0.21 | 0.39 | +0.18 | buy |
| BVF INC/IL | 1,632,845 | 2,075,545 | +442,700 | 0.78 | 0.98 | +0.20 | buy |
| BANK OF AMERICA CORP /DE/ | 643,000 | 1,913,829 | +1,270,829 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 1,235,000 | 1,862,250 | +627,250 | 1.15 | 2.08 | +0.93 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 854,000 | 1,729,000 | +875,000 | 0.02 | 0.04 | +0.03 | buy |
| Soleus Capital Management, L.P. | 441,978 | 1,654,978 | +1,213,000 | 0.27 | 1.05 | +0.79 | buy |
| BRAIDWELL LP | 0 | 1,629,182 | +1,629,182 | 0.00 | 1.11 | +1.11 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 1,311,715 | +1,311,715 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 1,260,689 | +1,260,689 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 1,141,980 | 1,209,059 | +67,079 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 300,000 | 1,150,000 | +850,000 | 0.23 | 0.91 | +0.68 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 169,889 | 1,105,118 | +935,229 | 0.00 | 0.00 | +0.00 | buy |
| Commodore Capital LP | 483,000 | 1,018,319 | +535,319 | 0.42 | 1.12 | +0.70 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 662,968 | 1,000,000 | +337,032 | 0.10 | 0.16 | +0.06 | buy |
| GOLDMAN SACHS GROUP INC | 60,106 | 946,320 | +886,214 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 172,149 | 891,405 | +719,256 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 731,586 | 861,711 | +130,125 | 0.02 | 0.03 | +0.01 | buy |
| Vestal Point Capital, LP | 0 | 775,000 | +775,000 | 0.00 | 0.33 | +0.33 | buy |
| Parkman Healthcare Partners LLC | 0 | 766,290 | +766,290 | 0.00 | 1.45 | +1.45 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 324,258 | 702,051 | +377,793 | 0.11 | 0.24 | +0.13 | buy |
| Squarepoint Ops LLC | 81,285 | 589,245 | +507,960 | 0.00 | 0.02 | +0.02 | buy |
| BAKER BROS. ADVISORS LP | 0 | 550,000 | +550,000 | 0.00 | 0.05 | +0.05 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 500,402 | +500,402 | 0.00 | 1.03 | +1.03 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 295,933 | 434,033 | +138,100 | 1.58 | 2.61 | +1.03 | buy |
| FRANKLIN RESOURCES INC | 0 | 404,191 | +404,191 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 300,000 | 375,000 | +75,000 | 0.59 | 0.52 | -0.07 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 120,114 | 357,200 | +237,086 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 30,556 | 344,521 | +313,965 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 185,122 | 324,452 | +139,330 | 1.73 | 3.67 | +1.94 | buy |
| CITADEL ADVISORS LLC | 193,735 | 323,833 | +130,098 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 310,008 | +310,008 | 0.00 | 0.03 | +0.03 | buy |
| Vivo Capital, LLC | 0 | 275,000 | +275,000 | 0.00 | 0.46 | +0.46 | buy |
| Eagle Health Investments LP | 0 | 235,093 | +235,093 | 0.00 | 0.72 | +0.72 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 232,294 | +232,294 | 0.00 | 0.61 | +0.61 | buy |
| PERCEPTIVE ADVISORS LLC | 139,667 | 219,813 | +80,146 | 0.04 | 0.06 | +0.02 | buy |
| Caption Management, LLC | 455,000 | 210,000 | -245,000 | 0.32 | 0.14 | -0.19 | sell |
| Jump Financial, LLC | 12,810 | 201,902 | +189,092 | 0.00 | 0.03 | +0.03 | buy |
| NAN FUNG TRINITY (HK) Ltd | 189,000 | 189,000 | 0 | 0.31 | 0.34 | +0.03 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 60,808 | 186,308 | +125,500 | 0.65 | 2.40 | +1.75 | buy |
| Walleye Capital LLC | 0 | 185,613 | +185,613 | 0.00 | 0.02 | +0.02 | buy |
| RTW INVESTMENTS, LP | 856,962 | 175,000 | -681,962 | 0.13 | 0.03 | -0.10 | sell |
| Ally Bridge Group (NY) LLC | 0 | 150,000 | +150,000 | 0.00 | 3.57 | +3.57 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 137,475 | +137,475 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,000 | 137,475 | +127,475 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 422,781 | 134,087 | -288,694 | 0.00 | 0.00 | -0.00 | sell |
| CenterBook Partners LP | 0 | 132,869 | +132,869 | 0.00 | 0.12 | +0.12 | buy |
| MORGAN STANLEY | 161,392 | 128,075 | -33,317 | 0.00 | 0.00 | -0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 159,324 | 125,582 | -33,742 | 0.43 | 0.42 | -0.01 | sell |
| HighVista Strategies LLC | 58,622 | 122,610 | +63,988 | 0.24 | 0.52 | +0.27 | buy |
| Aberdeen Group plc | 171,679 | 122,169 | -49,510 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 0 | 119,923 | +119,923 | 0.00 | 1.55 | +1.55 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 105,261 | +105,261 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 102,653 | +102,653 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 100,633 | +100,633 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 90,183 | +90,183 | 0.00 | 0.27 | +0.27 | buy |
| TD ASSET MANAGEMENT INC | 51,408 | 77,474 | +26,066 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 69,014 | +69,014 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 64,425 | 67,094 | +2,669 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 56,411 | +56,411 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 53,799 | +53,799 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 53,290 | +53,290 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 126,732 | 52,583 | -74,149 | 0.03 | 0.01 | -0.02 | sell |
| DEUTSCHE BANK AG\ | 150,000 | 41,166 | -108,834 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 0 | 38,240 | +38,240 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 40,821 | 38,158 | -2,663 | 0.00 | 0.00 | +0.00 | sell |
| Man Group plc | 46,553 | 36,876 | -9,677 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 0 | 36,576 | +36,576 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 28,309 | +28,309 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 27,227 | +27,227 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 25,712 | +25,712 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 7,918 | 24,544 | +16,626 | 0.05 | 0.14 | +0.10 | buy |
| MetLife Investment Management, LLC | 0 | 24,499 | +24,499 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 19,996 | 22,539 | +2,543 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 22,226 | +22,226 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 22,168 | +22,168 | 0.00 | 0.10 | +0.10 | buy |
| JPMORGAN CHASE & CO | 194,391 | 18,145 | -176,246 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 56,854 | 17,931 | -38,923 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 14,642 | 17,811 | +3,169 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 17,751 | 16,495 | -1,256 | 0.00 | 0.00 | +0.00 | sell |
| Quadrature Capital Ltd | 125,195 | 15,405 | -109,790 | 0.02 | 0.00 | -0.02 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 14,700 | +14,700 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 12,686 | +12,686 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 12,544 | +12,544 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 12,324 | +12,324 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 10,639 | +10,639 | 0.00 | 0.03 | +0.03 | buy |
| Lynx1 Capital Management LP | 0 | 10,100 | +10,100 | 0.00 | 0.02 | +0.02 | buy |
| Eversept Partners, LP | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| US BANCORP \DE\ | 3,387 | 5,684 | +2,297 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 4,055 | +4,055 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 3,792 | +3,792 | 0.00 | 0.00 | +0.00 | buy |
| PFS Partners, LLC | 2,000 | 2,000 | 0 | 0.01 | 0.01 | +0.00 | hold |