| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 0 | 1,053,983 | +1,053,983 | 0.00 | 0.03 | +0.03 | buy |
| Caligan Partners LP | 0 | 833,333 | +833,333 | 0.00 | 1.47 | +1.47 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 817,436 | +817,436 | 0.00 | 0.02 | +0.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 720,922 | +720,922 | 0.00 | 1.33 | +1.33 | buy |
| VANGUARD GROUP INC | 166,941 | 692,637 | +525,696 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 481,669 | +481,669 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 607,872 | 1,006,217 | +398,345 | 0.45 | 1.19 | +0.74 | buy |
| ORBIMED ADVISORS LLC | 967,000 | 1,349,300 | +382,300 | 0.12 | 0.41 | +0.29 | buy |
| BVF INC/IL | 1,028,049 | 1,355,256 | +327,207 | 0.18 | 0.70 | +0.51 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 258,769 | +258,769 | 0.00 | 0.01 | +0.01 | buy |
| Nantahala Capital Management, LLC | 995,000 | 1,235,000 | +240,000 | 0.35 | 0.97 | +0.62 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 11,321 | 228,297 | +216,976 | 0.00 | 0.07 | +0.07 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 213,572 | +213,572 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 406,571 | 605,842 | +199,271 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 188,080 | +188,080 | 0.00 | 2.36 | +2.36 | buy |
| Ally Bridge Group (NY) LLC | 0 | 178,100 | +178,100 | 0.00 | 1.90 | +1.90 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 137,431 | +137,431 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 125,000 | +125,000 | 0.00 | 0.51 | +0.51 | buy |
| Ikarian Capital, LLC | 35,300 | 159,777 | +124,477 | 0.06 | 0.41 | +0.35 | buy |
| Velan Capital Investment Management LP | 154,972 | 263,642 | +108,670 | 0.77 | 3.15 | +2.37 | buy |
| Exome Asset Management LLC | 0 | 100,036 | +100,036 | 0.00 | 0.84 | +0.84 | buy |
| Patient Square Capital LP | 0 | 100,000 | +100,000 | 0.00 | 0.34 | +0.34 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 98,700 | +98,700 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 85,247 | +85,247 | 0.00 | 0.02 | +0.02 | buy |
| DLD Asset Management, LP | 0 | 75,000 | +75,000 | 0.00 | 0.12 | +0.12 | buy |
| Aberdeen Group plc | 0 | 72,800 | +72,800 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 56,009 | +56,009 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 47,398 | +47,398 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 45,454 | +45,454 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 10,976 | 54,999 | +44,023 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 12,889 | 49,242 | +36,353 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 33,337 | +33,337 | 0.00 | 0.03 | +0.03 | buy |
| Birchview Capital, LP | 0 | 31,000 | +31,000 | 0.00 | 0.30 | +0.30 | buy |
| HighVista Strategies LLC | 0 | 27,778 | +27,778 | 0.00 | 0.09 | +0.09 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 24,628 | +24,628 | 0.00 | 0.02 | +0.02 | buy |
| Walleye Capital LLC | 20,613 | 44,743 | +24,130 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 13,950 | +13,950 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 11,215 | +11,215 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 9,346 | +9,346 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 1,929 | +1,929 | 0.00 | 0.00 | +0.00 | buy |
| PFS Partners, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 748 | +748 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 1 | 281 | +280 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 22 | 23 | +1 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5 | 5 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 139,667 | 139,667 | 0 | 0.03 | 0.05 | +0.03 | hold |
| Sio Capital Management, LLC | 72,173 | 72,173 | 0 | 0.14 | 0.23 | +0.09 | hold |
| Parallel Advisors, LLC | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Avion Wealth | 5 | 5 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Key FInancial Inc | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Commodore Capital LP | 483,000 | 483,000 | 0 | 0.17 | 0.30 | +0.13 | hold |
| TCG Crossover Management, LLC | 483,000 | 483,000 | 0 | 0.28 | 0.30 | +0.03 | hold |
| Activest Wealth Management | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BlackRock, Inc. | 155,899 | 154,251 | -1,648 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 22,673 | 18,575 | -4,098 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 110,460 | 104,189 | -6,271 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 83,724 | 45,208 | -38,516 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 104,730 | 32,393 | -72,337 | 0.08 | 0.04 | -0.04 | sell |
| RWA WEALTH PARTNERS, LLC | 261,016 | 86,516 | -174,500 | 0.02 | 0.01 | -0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 932,973 | 662,968 | -270,005 | 0.08 | 0.10 | +0.03 | sell |
| Deep Track Capital, LP | 567,103 | 144,600 | -422,503 | 0.09 | 0.05 | -0.04 | sell |