| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BVF INC/IL | 967,000 | 1,036,679 | +69,679 | 0.27 | 0.26 | -0.01 | buy |
| Ikarian Capital, LLC | 970,359 | 970,259 | -100 | 2.86 | 2.06 | -0.80 | sell |
| ORBIMED ADVISORS LLC | 967,000 | 967,000 | 0 | 0.17 | 0.15 | -0.02 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 967,000 | 967,000 | 0 | 0.11 | 0.10 | -0.01 | hold |
| Deep Track Capital, LP | 967,000 | 867,000 | -100,000 | 0.29 | 0.24 | -0.05 | sell |
| Affinity Asset Advisors, LLC | 45,000 | 550,765 | +505,765 | 0.07 | 0.64 | +0.57 | buy |
| Commodore Capital LP | 483,000 | 483,000 | 0 | 0.29 | 0.26 | -0.02 | hold |
| TCG Crossover Management, LLC | 483,000 | 483,000 | 0 | 0.39 | 0.35 | -0.04 | hold |
| VANGUARD GROUP INC | 10,368 | 165,801 | +155,433 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 164,092 | 163,992 | -100 | 0.05 | 0.04 | -0.01 | sell |
| BlackRock, Inc. | 0 | 133,235 | +133,235 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 117,356 | +117,356 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 109,972 | +109,972 | 0.00 | 0.71 | +0.71 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 10,111 | 104,853 | +94,742 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 98,519 | +98,519 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 71,458 | 71,458 | 0 | 0.30 | 0.15 | -0.15 | hold |
| BANK OF MONTREAL /CAN/ | 0 | 60,000 | +60,000 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 40,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 22,673 | +22,673 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 19,477 | +19,477 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 15,323 | +15,323 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 376 | 4,130 | +3,754 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4 | 4 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 2 | 2 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Key FInancial Inc | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Activest Wealth Management | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jaffetilchin Investment Partners, LLC | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 539,079 | 0 | -539,079 | 0.57 | 0.00 | -0.57 | sell |
| Avion Wealth | 5 | 0 | -5 | 0.00 | 0.00 | 0.00 | sell |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |