| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 137,431 | 659,979 | +522,548 | 0.00 | 0.01 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 0 | 475,625 | +475,625 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 56,009 | 507,550 | +451,541 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 0 | 441,978 | +441,978 | 0.00 | 0.34 | +0.34 | buy |
| UBS Group AG | 45,208 | 477,816 | +432,608 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 258,769 | 550,000 | +291,231 | 0.01 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 0 | 264,907 | +264,907 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 220,300 | +220,300 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 217,292 | +217,292 | 0.00 | 0.04 | +0.04 | buy |
| Patient Square Capital LP | 100,000 | 311,966 | +211,966 | 0.34 | 1.21 | +0.87 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5 | 197,747 | +197,742 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 195,873 | +195,873 | 0.00 | 0.11 | +0.11 | buy |
| NAN FUNG TRINITY (HK) Ltd | 0 | 189,000 | +189,000 | 0.00 | 0.27 | +0.27 | buy |
| JANE STREET GROUP, LLC | 0 | 178,855 | +178,855 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47,398 | 210,994 | +163,596 | 0.00 | 0.01 | +0.00 | buy |
| Boxer Capital Management, LLC | 125,000 | 275,000 | +150,000 | 0.51 | 1.09 | +0.59 | buy |
| DEUTSCHE BANK AG\ | 0 | 150,000 | +150,000 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 135,552 | +135,552 | 0.00 | 0.42 | +0.42 | buy |
| BlackRock, Inc. | 154,251 | 289,571 | +135,320 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 133,231 | +133,231 | 0.00 | 0.45 | +0.45 | buy |
| GREAT POINT PARTNERS LLC | 0 | 124,666 | +124,666 | 0.00 | 0.73 | +0.73 | buy |
| VANGUARD GROUP INC | 692,637 | 804,084 | +111,447 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 49,242 | 148,237 | +98,995 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 9,346 | 105,814 | +96,468 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 80,092 | +80,092 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 27,778 | 95,631 | +67,853 | 0.09 | 0.45 | +0.36 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 65,313 | +65,313 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 64,463 | +64,463 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 104,189 | 166,152 | +61,963 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 56,850 | +56,850 | 0.00 | 0.09 | +0.09 | buy |
| Caption Management, LLC | 0 | 52,641 | +52,641 | 0.00 | 0.04 | +0.04 | buy |
| Woodline Partners LP | 0 | 52,041 | +52,041 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 51,194 | +51,194 | 0.00 | 0.07 | +0.07 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 49,400 | +49,400 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 833,333 | 881,533 | +48,200 | 1.47 | 1.47 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 1,006,217 | 1,051,054 | +44,837 | 1.19 | 1.37 | +0.18 | buy |
| JPMORGAN CHASE & CO | 0 | 44,431 | +44,431 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 41,570 | +41,570 | 0.00 | 0.12 | +0.12 | buy |
| Squarepoint Ops LLC | 0 | 40,854 | +40,854 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 45,454 | 79,254 | +33,800 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 32,267 | +32,267 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 13,950 | 40,458 | +26,508 | 0.01 | 0.02 | +0.01 | buy |
| Aberdeen Group plc | 72,800 | 95,426 | +22,626 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 19,600 | +19,600 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 16,771 | +16,771 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 16,039 | +16,039 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 605,842 | 621,350 | +15,508 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 15,087 | +15,087 | 0.00 | 0.13 | +0.13 | buy |
| NORTHERN TRUST CORP | 18,575 | 32,204 | +13,629 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 13,092 | +13,092 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 8,737 | +8,737 | 0.00 | 0.00 | +0.00 | buy |
| Belvedere Trading LLC | 0 | 4,526 | +4,526 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 213,572 | 217,974 | +4,402 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 2,733 | +2,733 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 1,471 | +1,471 | 0.00 | 0.00 | +0.00 | buy |
| PFS Partners, LLC | 1,000 | 2,000 | +1,000 | 0.01 | 0.02 | +0.01 | buy |
| CITIGROUP INC | 400 | 1,143 | +743 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 1,355,256 | 1,355,257 | +1 | 0.70 | 0.83 | +0.13 | buy |
| PERCEPTIVE ADVISORS LLC | 139,667 | 139,667 | 0 | 0.05 | 0.05 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 662,968 | 662,968 | 0 | 0.10 | 0.12 | +0.02 | hold |
| Nantahala Capital Management, LLC | 1,235,000 | 1,235,000 | 0 | 0.97 | 1.34 | +0.37 | hold |
| Sio Capital Management, LLC | 72,173 | 72,173 | 0 | 0.23 | 0.22 | -0.01 | hold |
| Parallel Advisors, LLC | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Key FInancial Inc | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Commodore Capital LP | 483,000 | 483,000 | 0 | 0.30 | 0.58 | +0.28 | hold |
| TCG Crossover Management, LLC | 483,000 | 483,000 | 0 | 0.30 | 0.29 | -0.01 | hold |
| Velan Capital Investment Management LP | 263,642 | 263,642 | 0 | 3.15 | 2.79 | -0.36 | hold |
| Activest Wealth Management | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Avion Wealth | 5 | 0 | -5 | 0.00 | 0.00 | 0.00 | sell |
| SBI Securities Co., Ltd. | 23 | 0 | -23 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 281 | 1 | -280 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 748 | 0 | -748 | 0.00 | 0.00 | -0.00 | sell |
| BIT Capital GmbH | 1,929 | 0 | -1,929 | 0.00 | 0.00 | -0.00 | sell |
| Quadrature Capital Ltd | 54,999 | 53,044 | -1,955 | 0.01 | 0.01 | +0.00 | sell |
| Walleye Capital LLC | 44,743 | 41,693 | -3,050 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 11,215 | 0 | -11,215 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 24,628 | 0 | -24,628 | 0.02 | 0.00 | -0.02 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 228,297 | 202,127 | -26,170 | 0.07 | 0.09 | +0.02 | sell |
| Birchview Capital, LP | 31,000 | 0 | -31,000 | 0.30 | 0.00 | -0.30 | sell |
| ADAR1 Capital Management, LLC | 32,393 | 0 | -32,393 | 0.04 | 0.00 | -0.04 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 33,337 | 0 | -33,337 | 0.03 | 0.00 | -0.03 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 188,080 | 153,313 | -34,767 | 2.36 | 1.49 | -0.86 | sell |
| CITADEL ADVISORS LLC | 481,669 | 419,491 | -62,178 | 0.00 | 0.01 | +0.00 | sell |
| DLD Asset Management, LP | 75,000 | 0 | -75,000 | 0.12 | 0.00 | -0.12 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 98,700 | 18,300 | -80,400 | 0.00 | 0.00 | -0.00 | sell |
| CANTOR FITZGERALD, L. P. | 85,247 | 0 | -85,247 | 0.02 | 0.00 | -0.02 | sell |
| RWA WEALTH PARTNERS, LLC | 86,516 | 0 | -86,516 | 0.01 | 0.00 | -0.01 | sell |
| Exome Asset Management LLC | 100,036 | 0 | -100,036 | 0.84 | 0.00 | -0.84 | sell |
| Ikarian Capital, LLC | 159,777 | 31,106 | -128,671 | 0.41 | 0.07 | -0.34 | sell |
| Deep Track Capital, LP | 144,600 | 0 | -144,600 | 0.05 | 0.00 | -0.05 | sell |
| ORBIMED ADVISORS LLC | 1,349,300 | 1,187,300 | -162,000 | 0.41 | 0.44 | +0.03 | sell |
| Ally Bridge Group (NY) LLC | 178,100 | 0 | -178,100 | 1.90 | 0.00 | -1.90 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 720,922 | 524,436 | -196,486 | 1.33 | 1.38 | +0.05 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 817,436 | 439,312 | -378,124 | 0.02 | 0.01 | -0.01 | sell |
| Point72 Asset Management, L.P. | 1,053,983 | 627,502 | -426,481 | 0.03 | 0.02 | -0.01 | sell |