| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 258,769 | 550,000 | +291,231 | 0.01 | 0.02 | +0.01 | buy |
| Patient Square Capital LP | 100,000 | 311,966 | +211,966 | 0.34 | 1.21 | +0.87 | buy |
| Boxer Capital Management, LLC | 125,000 | 275,000 | +150,000 | 0.51 | 1.09 | +0.59 | buy |
| HighVista Strategies LLC | 27,778 | 95,631 | +67,853 | 0.09 | 0.45 | +0.36 | buy |
| Caligan Partners LP | 833,333 | 881,533 | +48,200 | 1.47 | 1.47 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 1,006,217 | 1,051,054 | +44,837 | 1.19 | 1.37 | +0.18 | buy |
| Aberdeen Group plc | 72,800 | 95,426 | +22,626 | 0.00 | 0.00 | +0.00 | buy |
| PFS Partners, LLC | 1,000 | 2,000 | +1,000 | 0.01 | 0.02 | +0.01 | buy |
| BVF INC/IL | 1,355,256 | 1,355,257 | +1 | 0.70 | 0.83 | +0.13 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 188,080 | 153,313 | -34,767 | 2.36 | 1.49 | -0.86 | sell |
| Ikarian Capital, LLC | 159,777 | 31,106 | -128,671 | 0.41 | 0.07 | -0.34 | sell |
| ORBIMED ADVISORS LLC | 1,349,300 | 1,187,300 | -162,000 | 0.41 | 0.44 | +0.03 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 720,922 | 524,436 | -196,486 | 1.33 | 1.38 | +0.05 | sell |