| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Stonepine Capital Management, LLC | 0 | 468,793 | +468,793 | 0.00 | 1.34 | +1.34 | buy |
| Alyeska Investment Group, L.P. | 0 | 372,256 | +372,256 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,000,000 | 1,300,000 | +300,000 | 0.07 | 0.09 | +0.02 | buy |
| VANGUARD GROUP INC | 254,148 | 339,148 | +85,000 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 43,200 | +43,200 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 38,000 | +38,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 66,553 | 90,866 | +24,313 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 55,233 | 72,057 | +16,824 | 0.00 | 0.00 | +0.00 | buy |
| Atria Investments, Inc | 26,503 | 34,012 | +7,509 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 12,307 | 16,873 | +4,566 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 43,631 | 46,552 | +2,921 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,224 | +1,224 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 0 | 45 | +45 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 18,900 | 18,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BROWN BROTHERS HARRIMAN & CO | 308 | 308 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aisling Capital Management LP | 521,114 | 521,114 | 0 | 0.88 | 0.65 | -0.23 | hold |
| Soleus Capital Management, L.P. | 783,904 | 783,904 | 0 | 0.29 | 0.21 | -0.08 | hold |
| TRITONPOINT WEALTH, LLC | 15,119 | 15,119 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| MERITAGE PORTFOLIO MANAGEMENT | 46,000 | 46,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BlackRock, Inc. | 16,066 | 15,948 | -118 | 0.00 | 0.00 | -0.00 | sell |
| Connective Capital Management, LLC | 10,000 | 0 | -10,000 | 0.03 | 0.00 | -0.03 | sell |
| FIRST MANHATTAN CO. LLC. | 13,226 | 0 | -13,226 | 0.00 | 0.00 | -0.00 | sell |
| PVG ASSET MANAGEMENT CORP | 15,115 | 0 | -15,115 | 0.27 | 0.00 | -0.27 | sell |
| BML Capital Management, LLC | 153,887 | 0 | -153,887 | 0.40 | 0.00 | -0.40 | sell |