| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 3,256,519 | 4,483,016 | +1,226,497 | 1.20 | 2.42 | +1.22 | buy |
| Soleus Capital Management, L.P. | 143,000 | 1,115,000 | +972,000 | 0.16 | 1.44 | +1.28 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 250,327 | 434,413 | +184,086 | 0.01 | 0.03 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 297,769 | 165,603 | +132,166 | 0.04 | 0.03 | 0.00 | sell |
| Affinity Asset Advisors, LLC | 690,112 | 810,253 | +120,141 | 1.42 | 1.94 | +0.52 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 185,070 | 237,104 | +52,034 | 0.01 | 0.02 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 126,001 | 102,321 | +23,680 | 0.00 | 0.01 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 5,611 | 9,404 | +3,793 | 0.01 | 0.02 | +0.01 | buy |
| AlphaQuest LLC | 5,725 | 9,174 | +3,449 | 0.01 | 0.02 | 0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 15,718 | 16,517 | +799 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 10,356 | 9,693 | -663 | 0.07 | 0.08 | +0.01 | sell |
| NATIXIS | 5,472 | 4,783 | -689 | 0.00 | 0.00 | -0.00 | sell |
| 49 WEALTH MANAGEMENT, LLC | 13,688 | 12,503 | -1,185 | 0.04 | 0.04 | +0.00 | sell |
| Corton Capital Inc. | 39,853 | 27,375 | -12,478 | 0.13 | 0.15 | +0.02 | sell |
| Candriam S.C.A. | 918,110 | 892,110 | -26,000 | 0.07 | 0.08 | +0.02 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 142,146 | 112,779 | -29,367 | 0.00 | 0.00 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 161,011 | 88,260 | -72,751 | 0.04 | 0.03 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,389,966 | 2,196,169 | -193,797 | 0.00 | 0.00 | +0.00 | sell |
| ARK Investment Management LLC | 3,194,999 | 2,635,338 | -559,661 | 0.20 | 0.27 | +0.07 | sell |
| Bain Capital Life Sciences Investors, LLC | 1,822,883 | 1,132,397 | -690,486 | 1.80 | 1.34 | -0.47 | sell |
| WASATCH ADVISORS LP | 2,749,745 | 1,236,753 | -1,512,992 | 0.16 | 0.10 | -0.06 | sell |