| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 3,256,519 | 4,483,016 | +1,226,497 | 1.20 | 2.42 | +1.22 | buy |
| BAKER BROS. ADVISORS LP | 3,882,125 | 3,882,125 | 0 | 0.46 | 0.72 | +0.26 | hold |
| Deep Track Capital, LP | 2,997,830 | 2,997,830 | 0 | 1.08 | 1.27 | +0.18 | hold |
| STATE STREET CORP | 921,322 | 2,729,336 | +1,808,014 | 0.00 | 0.00 | +0.00 | buy |
| ARK Investment Management LLC | 3,194,999 | 2,635,338 | -559,661 | 0.20 | 0.27 | +0.07 | sell |
| VANGUARD GROUP INC | 2,598,097 | 2,584,300 | -13,797 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 3,135,037 | 2,530,799 | -604,238 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,389,966 | 2,196,169 | -193,797 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 504,205 | 1,499,368 | +995,163 | 0.00 | 0.01 | +0.01 | buy |
| WASATCH ADVISORS LP | 2,749,745 | 1,236,753 | -1,512,992 | 0.16 | 0.10 | -0.06 | sell |
| Bain Capital Life Sciences Investors, LLC | 1,822,883 | 1,132,397 | -690,486 | 1.80 | 1.34 | -0.47 | sell |
| Soleus Capital Management, L.P. | 143,000 | 1,115,000 | +972,000 | 0.16 | 1.44 | +1.28 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,080,523 | 1,100,335 | +19,812 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,000,044 | 966,453 | -33,591 | 0.00 | 0.00 | +0.00 | sell |
| Candriam S.C.A. | 918,110 | 892,110 | -26,000 | 0.07 | 0.08 | +0.02 | sell |
| Affinity Asset Advisors, LLC | 690,112 | 810,253 | +120,141 | 1.42 | 1.94 | +0.52 | buy |
| Pictet Asset Management Holding SA | 773,588 | 726,941 | -46,647 | 0.01 | 0.01 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 622,297 | 642,190 | +19,893 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 281,900 | 492,666 | +210,766 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 250,327 | 434,413 | +184,086 | 0.01 | 0.03 | +0.02 | buy |
| NORTHERN TRUST CORP | 416,814 | 404,010 | -12,804 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 377,588 | 374,249 | -3,339 | 0.00 | 0.00 | +0.00 | sell |
| BESSEMER GROUP INC | 357,287 | 357,287 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ArrowMark Colorado Holdings LLC | 314,762 | 314,762 | 0 | 0.04 | 0.05 | +0.02 | hold |
| Invesco Ltd. | 50,825 | 312,910 | +262,085 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 300,000 | +300,000 | 0.00 | 1.20 | +1.20 | buy |
| WestHill Financial Advisors, Inc. | 283,333 | 283,333 | 0 | 0.77 | 1.02 | +0.25 | hold |
| PRIMECAP MANAGEMENT CO/CA/ | 0 | 279,000 | +279,000 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 0 | 267,210 | +267,210 | 0.00 | 0.86 | +0.86 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 262,162 | +262,162 | 0.00 | 0.03 | +0.03 | buy |
| Parkman Healthcare Partners LLC | 0 | 250,000 | +250,000 | 0.00 | 0.45 | +0.45 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 185,070 | 237,104 | +52,034 | 0.01 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 205,324 | 233,136 | +27,812 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 31,869 | 214,716 | +182,847 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 159,318 | 212,879 | +53,561 | 0.04 | 0.06 | +0.03 | buy |
| Rafferty Asset Management, LLC | 0 | 211,425 | +211,425 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 94,772 | 211,316 | +116,544 | 0.00 | 0.01 | +0.01 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 195,136 | 187,743 | -7,393 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 15,145 | 184,780 | +169,635 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 258,400 | 180,800 | -77,600 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 115,200 | 179,300 | +64,100 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 29,100 | 177,900 | +148,800 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 76,402 | 168,942 | +92,540 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 297,769 | 165,603 | -132,166 | 0.04 | 0.03 | -0.01 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 23,687 | 160,293 | +136,606 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 173,077 | 159,218 | -13,859 | 0.00 | 0.00 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 158,167 | 158,167 | 0 | 0.03 | 0.05 | +0.03 | hold |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 142,146 | 112,779 | -29,367 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 110,712 | 105,864 | -4,848 | 0.00 | 0.00 | +0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 126,001 | 102,321 | -23,680 | 0.00 | 0.01 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 0 | 97,176 | +97,176 | 0.00 | 0.00 | +0.00 | buy |
| Jasper Ridge Partners, L.P. | 95,711 | 95,711 | 0 | 0.04 | 0.04 | +0.00 | hold |
| KENNEDY CAPITAL MANAGEMENT LLC | 161,011 | 88,260 | -72,751 | 0.04 | 0.03 | -0.01 | sell |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.40 | 0.49 | +0.09 | hold |
| Ensign Peak Advisors, Inc | 79,907 | 79,907 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 79,770 | +79,770 | 0.00 | 0.03 | +0.03 | buy |
| RHUMBLINE ADVISERS | 75,107 | 77,771 | +2,664 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 323,729 | 71,362 | -252,367 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 0 | 67,250 | +67,250 | 0.00 | 0.09 | +0.09 | buy |
| FRANKLIN RESOURCES INC | 22,621 | 64,472 | +41,851 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 43,290 | 60,066 | +16,776 | 0.00 | 0.00 | +0.00 | buy |
| Pennant Investors, LP | 56,800 | 56,800 | 0 | 0.18 | 0.23 | +0.05 | hold |
| JANE STREET GROUP, LLC | 74,842 | 56,714 | -18,128 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 30,498 | 53,542 | +23,044 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 51,829 | +51,829 | 0.00 | 0.07 | +0.07 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 49,018 | 50,838 | +1,820 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 72,540 | 50,529 | -22,011 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 68,739 | 47,515 | -21,224 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 46,460 | 46,460 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Duquesne Family Office LLC | 0 | 44,200 | +44,200 | 0.00 | 0.02 | +0.02 | buy |
| Amundi | 43,755 | 43,755 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cubist Systematic Strategies, LLC | 0 | 36,256 | +36,256 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 0 | 35,608 | +35,608 | 0.00 | 0.14 | +0.14 | buy |
| JPMORGAN CHASE & CO | 47,990 | 34,324 | -13,666 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 67,323 | 33,678 | -33,645 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 0 | 33,060 | +33,060 | 0.00 | 0.02 | +0.02 | buy |
| Mariner, LLC | 31,539 | 31,552 | +13 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 24,276 | 30,904 | +6,628 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 39,853 | 27,375 | -12,478 | 0.13 | 0.15 | +0.02 | sell |
| Blackstone Inc. | 27,119 | 27,119 | 0 | 0.00 | 0.00 | +0.00 | hold |
| XTX Topco Ltd | 11,782 | 26,340 | +14,558 | 0.03 | 0.05 | +0.03 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 23,661 | 23,460 | -201 | 0.00 | 0.00 | +0.00 | sell |
| MetLife Investment Management, LLC | 23,288 | 23,288 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SG Americas Securities, LLC | 26,601 | 22,194 | -4,407 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 19,156 | 21,167 | +2,011 | 0.00 | 0.00 | +0.00 | buy |
| BBR PARTNERS, LLC | 20,988 | 20,988 | 0 | 0.02 | 0.02 | +0.00 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 15,823 | 20,295 | +4,472 | 0.00 | 0.01 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 18,511 | 18,511 | 0 | 0.03 | 0.04 | +0.01 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,244 | 18,359 | -885 | 0.00 | 0.00 | +0.00 | sell |
| J.W. COLE ADVISORS, INC. | 0 | 18,028 | +18,028 | 0.00 | 0.01 | +0.01 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 17,611 | 17,461 | -150 | 0.00 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 15,718 | 16,517 | +799 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,156 | 16,331 | +175 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 38,456 | 15,985 | -22,471 | 0.00 | 0.00 | -0.00 | sell |
| FIDUCIARY TRUST CO | 14,074 | 14,074 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Verition Fund Management LLC | 0 | 13,175 | +13,175 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 14,135 | 12,953 | -1,182 | 0.00 | 0.00 | +0.00 | sell |
| 49 WEALTH MANAGEMENT, LLC | 13,688 | 12,503 | -1,185 | 0.04 | 0.04 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 27,456 | 12,042 | -15,414 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 10,980 | 11,978 | +998 | 0.00 | 0.00 | +0.00 | buy |