| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 3,000,000 | 5,500,000 | +2,500,000 | 2.12 | 2.12 | -0.00 | buy |
| Commodore Capital LP | 3,000,000 | 3,978,907 | +978,907 | 4.14 | 3.48 | -0.66 | buy |
| Vestal Point Capital, LP | 485,000 | 1,125,552 | +640,552 | 0.54 | 0.95 | +0.41 | buy |
| Soleus Capital Management, L.P. | 2,102,833 | 2,422,833 | +320,000 | 3.00 | 2.26 | -0.74 | buy |
| TWINBEECH CAPITAL LP | 29,776 | 169,280 | +139,504 | 0.01 | 0.04 | +0.03 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 114,623 | 205,100 | +90,477 | 0.05 | 0.06 | +0.01 | buy |
| ARK Investment Management LLC | 1,530,293 | 1,590,910 | +60,617 | 0.24 | 0.19 | -0.05 | buy |
| T. Rowe Price Investment Management, Inc. | 2,380,428 | 2,428,283 | +47,855 | 0.03 | 0.02 | -0.01 | buy |
| NEOS Investment Management LLC | 22,557 | 59,146 | +36,589 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 22,557 | 59,146 | +36,589 | 0.18 | 0.21 | +0.03 | buy |
| Integral Health Asset Management, LLC | 250,000 | 275,000 | +25,000 | 0.40 | 0.35 | -0.05 | buy |
| EntryPoint Capital, LLC | 14,105 | 37,559 | +23,454 | 0.11 | 0.20 | +0.09 | buy |
| ADAR1 Capital Management, LLC | 11,000 | 21,200 | +10,200 | 0.04 | 0.05 | +0.01 | buy |
| Polymer Capital Management (HK) LTD | 50,098 | 58,898 | +8,800 | 0.17 | 0.12 | -0.04 | buy |
| Patient Square Capital LP | 446,296 | 447,296 | +1,000 | 3.14 | 2.20 | -0.95 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,487 | 1,814 | +327 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 22,904 | 23,187 | +283 | 0.02 | 0.01 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 15,020 | 15,222 | +202 | 0.03 | 0.02 | -0.01 | buy |
| J.Safra Asset Management Corp | 15 | 97 | +82 | 0.00 | 0.00 | +0.00 | buy |
| SAMLYN CAPITAL, LLC | 515,840 | 515,103 | -737 | 0.15 | 0.09 | -0.06 | sell |
| Rafferty Asset Management, LLC | 116,186 | 110,082 | -6,104 | 0.01 | 0.01 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 67,404 | 43,006 | -24,398 | 0.00 | 0.00 | -0.00 | sell |
| WASATCH ADVISORS LP | 599,401 | 569,797 | -29,604 | 0.06 | 0.04 | -0.02 | sell |
| PERCEPTIVE ADVISORS LLC | 330,614 | 297,553 | -33,061 | 0.17 | 0.12 | -0.05 | sell |
| Nikko Asset Management Americas, Inc. | 789,222 | 755,970 | -33,252 | 0.16 | 0.12 | -0.05 | sell |
| Rhenman & Partners Asset Management AB | 290,000 | 249,336 | -40,664 | 0.56 | 0.34 | -0.22 | sell |
| Candriam S.C.A. | 634,626 | 588,931 | -45,695 | 0.07 | 0.04 | -0.03 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,007,327 | 2,913,368 | -93,959 | 0.01 | 0.00 | -0.00 | sell |
| Cinctive Capital Management LP | 158,972 | 38,770 | -120,202 | 0.15 | 0.04 | -0.12 | sell |
| Affinity Asset Advisors, LLC | 940,083 | 810,669 | -129,414 | 2.37 | 0.92 | -1.45 | sell |
| Redmile Group, LLC | 4,192,627 | 4,051,927 | -140,700 | 5.50 | 4.55 | -0.96 | sell |
| Parkman Healthcare Partners LLC | 532,172 | 350,420 | -181,752 | 1.34 | 0.49 | -0.84 | sell |
| Woodline Partners LP | 338,462 | 100,204 | -238,258 | 0.04 | 0.01 | -0.04 | sell |
| Opaleye Management Inc. | 378,500 | 115,000 | -263,500 | 1.25 | 0.30 | -0.94 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,279,691 | 715,940 | -563,751 | 0.20 | 0.08 | -0.12 | sell |