| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 8,875,194 | 8,925,642 | +50,448 | 0.00 | 0.00 | -0.00 | buy |
| Redmile Group, LLC | 8,093,908 | 7,732,808 | -361,100 | 11.31 | 7.94 | -3.37 | sell |
| Vestal Point Capital, LP | 4,690,000 | 6,500,000 | +1,810,000 | 3.26 | 2.82 | -0.45 | buy |
| Deep Track Capital, LP | 7,036,455 | 6,345,244 | -691,211 | 3.04 | 2.03 | -1.02 | sell |
| FMR LLC | 4,234,158 | 5,541,271 | +1,307,113 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 3,559,501 | 5,141,195 | +1,581,694 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 4,881,069 | 4,931,999 | +50,930 | 0.01 | 0.00 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 4,658,556 | 4,658,556 | 0 | 0.52 | 0.41 | -0.10 | hold |
| GENERAL ATLANTIC, L.P. | 4,897,159 | 4,101,865 | -795,294 | 3.23 | 2.96 | -0.27 | sell |
| PERCEPTIVE ADVISORS LLC | 3,555,877 | 3,710,877 | +155,000 | 1.24 | 1.14 | -0.10 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,248,361 | 3,290,233 | +41,872 | 0.01 | 0.01 | -0.00 | buy |
| Pictet Asset Management Holding SA | 3,467,600 | 2,726,138 | -741,462 | 0.06 | 0.04 | -0.02 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,384,998 | 2,520,229 | +135,231 | 0.00 | 0.00 | -0.00 | buy |
| Rubric Capital Management LP | 2,473,885 | 2,473,885 | 0 | 0.56 | 0.47 | -0.09 | hold |
| DEUTSCHE BANK AG\ | 2,486,792 | 2,295,024 | -191,768 | 0.02 | 0.01 | -0.00 | sell |
| Commodore Capital LP | 2,275,000 | 2,275,000 | 0 | 2.87 | 2.04 | -0.83 | hold |
| BRAIDWELL LP | 2,183,864 | 1,750,766 | -433,098 | 1.32 | 0.91 | -0.42 | sell |
| ARK Investment Management LLC | 1,602,539 | 1,721,135 | +118,596 | 0.20 | 0.21 | +0.01 | buy |
| Longaeva Partners L.P. | 927,729 | 1,490,202 | +562,473 | 2.09 | 1.11 | -0.98 | buy |
| CITADEL ADVISORS LLC | 1,152,930 | 1,343,700 | +190,770 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,077,573 | 1,318,659 | +241,086 | 0.00 | 0.00 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,297,893 | 1,297,893 | 0 | 0.38 | 0.33 | -0.05 | hold |
| Kynam Capital Management, LP | 1,970,357 | 1,194,757 | -775,600 | 2.43 | 1.18 | -1.26 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 1,290,554 | 1,181,146 | -109,408 | 0.01 | 0.01 | -0.00 | sell |
| Nikko Asset Management Americas, Inc. | 1,290,554 | 1,181,146 | -109,408 | 0.28 | 0.26 | -0.02 | sell |
| UBS Group AG | 423,425 | 976,362 | +552,937 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 967,620 | 967,620 | 0 | 1.32 | 0.88 | -0.44 | hold |
| Soleus Capital Management, L.P. | 1,219,394 | 938,163 | -281,231 | 0.98 | 0.59 | -0.39 | sell |
| Woodline Partners LP | 925,444 | 925,444 | 0 | 0.07 | 0.05 | -0.01 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 965,892 | 924,039 | -41,853 | 0.00 | 0.00 | -0.00 | sell |
| Capital World Investors | 0 | 893,327 | +893,327 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 805,682 | 854,466 | +48,784 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 784,409 | 812,601 | +28,192 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 736,558 | 802,153 | +65,595 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 430,986 | 780,696 | +349,710 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 300,000 | 700,000 | +400,000 | 0.29 | 0.57 | +0.29 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 735,174 | 620,820 | -114,354 | 0.05 | 0.04 | -0.01 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 261,204 | 561,250 | +300,046 | 0.10 | 0.18 | +0.08 | buy |
| Handelsbanken Fonder AB | 547,000 | 547,000 | 0 | 0.03 | 0.03 | -0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 179,759 | 546,297 | +366,538 | 0.00 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 534,259 | 534,259 | 0 | 0.05 | 0.04 | -0.01 | hold |
| Qube Research & Technologies Ltd | 25,989 | 485,212 | +459,223 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 171,102 | 477,410 | +306,308 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 3,211,680 | 449,106 | -2,762,574 | 0.10 | 0.01 | -0.08 | sell |
| Fisher Asset Management, LLC | 0 | 384,831 | +384,831 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 353,733 | +353,733 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 344,203 | +344,203 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 275,178 | 321,360 | +46,182 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 315,226 | +315,226 | 0.00 | 0.94 | +0.94 | buy |
| ArrowMark Colorado Holdings LLC | 314,762 | 314,762 | 0 | 0.13 | 0.13 | -0.00 | hold |
| Rhenman & Partners Asset Management AB | 537,500 | 313,500 | -224,000 | 0.95 | 0.60 | -0.35 | sell |
| BESSEMER GROUP INC | 306,003 | 306,003 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Bank of New York Mellon Corp | 288,143 | 295,345 | +7,202 | 0.00 | 0.00 | -0.00 | buy |
| Foresite Capital Management V, LLC | 0 | 265,000 | +265,000 | 0.00 | 1.52 | +1.52 | buy |
| WestHill Financial Advisors, Inc. | 228,333 | 228,333 | 0 | 0.82 | 0.68 | -0.15 | hold |
| HighVista Strategies LLC | 0 | 226,546 | +226,546 | 0.00 | 0.97 | +0.97 | buy |
| Squarepoint Ops LLC | 0 | 224,535 | +224,535 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 132,094 | 223,363 | +91,269 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 77,359 | 209,694 | +132,335 | 0.01 | 0.02 | +0.01 | buy |
| Invesco Ltd. | 343,830 | 203,609 | -140,221 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 237,200 | 189,250 | -47,950 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 172,364 | 179,177 | +6,813 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 168,843 | 157,350 | -11,493 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 150,000 | 150,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rafferty Asset Management, LLC | 90,515 | 149,523 | +59,008 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 118,598 | 123,367 | +4,769 | 0.00 | 0.00 | -0.00 | buy |
| Burkehill Global Management, LP | 118,972 | 118,972 | 0 | 0.15 | 0.09 | -0.06 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 118,000 | +118,000 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 86,423 | 107,663 | +21,240 | 0.03 | 0.02 | -0.00 | buy |
| Boxer Capital Management, LLC | 100,000 | 100,000 | 0 | 0.42 | 0.20 | -0.21 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 68,019 | 99,042 | +31,023 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 98,190 | 98,190 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jasper Ridge Partners, L.P. | 95,711 | 95,711 | 0 | 0.04 | 0.03 | -0.01 | hold |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 80,000 | 90,000 | +10,000 | 0.02 | 0.02 | -0.00 | buy |
| Jump Financial, LLC | 80,037 | 89,518 | +9,481 | 0.02 | 0.02 | +0.00 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.79 | 0.50 | -0.28 | hold |
| SEI INVESTMENTS CO | 35,976 | 82,108 | +46,132 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 63,482 | 81,841 | +18,359 | 0.00 | 0.00 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 65,545 | 81,760 | +16,215 | 0.09 | 0.10 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,553 | 81,455 | +30,902 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 42,878 | 78,057 | +35,179 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 79,325 | 77,897 | -1,428 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 84,989 | 70,765 | -14,224 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 34,580 | 66,993 | +32,413 | 0.02 | 0.04 | +0.02 | buy |
| ExodusPoint Capital Management, LP | 0 | 62,503 | +62,503 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 124,749 | 61,825 | -62,924 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 20,520 | 61,774 | +41,254 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 58,898 | 58,898 | 0 | 0.17 | 0.13 | -0.05 | hold |
| WELLS FARGO & COMPANY/MN | 117,854 | 56,137 | -61,717 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 72,070 | 56,070 | -16,000 | 0.10 | 0.05 | -0.05 | sell |
| MetLife Investment Management, LLC | 55,345 | 55,948 | +603 | 0.01 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 55,138 | +55,138 | 0.00 | 0.02 | +0.02 | buy |
| ALGERT GLOBAL LLC | 119,657 | 51,347 | -68,310 | 0.04 | 0.01 | -0.02 | sell |
| JPMORGAN CHASE & CO | 47,288 | 50,357 | +3,069 | 0.00 | 0.00 | -0.00 | buy |
| Cinctive Capital Management LP | 47,707 | 45,171 | -2,536 | 0.05 | 0.05 | -0.01 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 44,976 | +44,976 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 44,200 | +44,200 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 43,743 | 42,603 | -1,140 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 31,191 | 40,928 | +9,737 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 11,520 | 40,386 | +28,866 | 0.01 | 0.01 | +0.01 | buy |