| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Deep Track Capital, LP | 2,997,830 | 3,991,500 | +993,670 | 1.27 | 2.49 | +1.22 | buy |
| Soleus Capital Management, L.P. | 1,115,000 | 2,055,916 | +940,916 | 1.44 | 3.78 | +2.34 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,196,169 | 2,835,119 | +638,950 | 0.00 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 892,110 | 1,164,246 | +272,136 | 0.08 | 0.15 | +0.06 | buy |
| Parkman Healthcare Partners LLC | 250,000 | 474,679 | +224,679 | 0.45 | 1.35 | +0.90 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 237,104 | 62,298 | +174,806 | 0.02 | 0.01 | -0.01 | sell |
| ExodusPoint Capital Management, LP | 165,603 | 320,552 | +154,949 | 0.03 | 0.08 | 0.00 | buy |
| Opaleye Management Inc. | 267,210 | 418,928 | +151,718 | 0.86 | 2.00 | +1.14 | buy |
| Ikarian Capital, LLC | 300,000 | 440,500 | +140,500 | 1.20 | 2.87 | +1.67 | buy |
| Affinity Asset Advisors, LLC | 810,253 | 912,000 | +101,747 | 1.94 | 3.00 | +1.06 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 102,321 | 33,245 | +69,076 | 0.01 | 0.00 | 0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 279,000 | 290,000 | +11,000 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 16,517 | 27,507 | +10,990 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 33,060 | 25,588 | +7,472 | 0.02 | 0.02 | 0.00 | sell |
| AlphaQuest LLC | 9,174 | 6,146 | +3,028 | 0.02 | 0.02 | 0.00 | sell |
| PDT Partners, LLC | 67,250 | 67,224 | -26 | 0.09 | 0.13 | +0.04 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 18,511 | 18,358 | -153 | 0.04 | 0.06 | +0.02 | sell |
| NATIXIS | 4,783 | 3,629 | -1,154 | 0.00 | 0.00 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 158,167 | 155,984 | -2,183 | 0.05 | 0.13 | +0.08 | sell |
| China Universal Asset Management Co., Ltd. | 9,404 | 6,969 | -2,435 | 0.02 | 0.02 | +0.00 | sell |
| nVerses Capital, LLC | 5,200 | 1,600 | -3,600 | 0.18 | 0.02 | -0.16 | sell |
| VIRTUS ADVISERS, LLC | 9,693 | 5,411 | -4,282 | 0.08 | 0.06 | -0.02 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 112,779 | 98,171 | -14,608 | 0.00 | 0.00 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 88,260 | 59,853 | -28,407 | 0.03 | 0.03 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 35,608 | 3,500 | -32,108 | 0.14 | 0.01 | -0.13 | sell |
| BESSEMER GROUP INC | 357,287 | 306,003 | -51,284 | 0.01 | 0.01 | +0.00 | sell |
| Redmile Group, LLC | 4,483,016 | 4,423,616 | -59,400 | 2.42 | 5.58 | +3.16 | sell |
| Rafferty Asset Management, LLC | 211,425 | 137,316 | -74,109 | 0.01 | 0.01 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 434,413 | 224,908 | -209,505 | 0.03 | 0.02 | -0.01 | sell |
| ARK Investment Management LLC | 2,635,338 | 2,323,332 | -312,006 | 0.27 | 0.43 | +0.16 | sell |
| WASATCH ADVISORS LP | 1,236,753 | 858,067 | -378,686 | 0.10 | 0.10 | +0.00 | sell |