| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 4,483,016 | 4,423,616 | -59,400 | 2.42 | 5.58 | +3.16 | sell |
| Deep Track Capital, LP | 2,997,830 | 3,991,500 | +993,670 | 1.27 | 2.49 | +1.22 | buy |
| BAKER BROS. ADVISORS LP | 3,882,125 | 3,882,125 | 0 | 0.72 | 1.04 | +0.32 | hold |
| VANGUARD GROUP INC | 2,584,300 | 3,625,014 | +1,040,714 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 233,136 | 3,201,865 | +2,968,729 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,196,169 | 2,835,119 | +638,950 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 2,729,336 | 2,708,533 | -20,803 | 0.00 | 0.00 | +0.00 | sell |
| ARK Investment Management LLC | 2,635,338 | 2,323,332 | -312,006 | 0.27 | 0.43 | +0.16 | sell |
| T. Rowe Price Investment Management, Inc. | 0 | 2,189,192 | +2,189,192 | 0.00 | 0.03 | +0.03 | buy |
| Soleus Capital Management, L.P. | 1,115,000 | 2,055,916 | +940,916 | 1.44 | 3.78 | +2.34 | buy |
| MORGAN STANLEY | 2,530,799 | 1,989,700 | -541,099 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,100,335 | 1,321,734 | +221,399 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 1,283,108 | +1,283,108 | 0.00 | 0.26 | +0.26 | buy |
| Pictet Asset Management Holding SA | 726,941 | 1,173,518 | +446,577 | 0.01 | 0.03 | +0.02 | buy |
| Candriam S.C.A. | 892,110 | 1,164,246 | +272,136 | 0.08 | 0.15 | +0.06 | buy |
| DEUTSCHE BANK AG\ | 1,499,368 | 1,048,394 | -450,974 | 0.01 | 0.01 | -0.00 | sell |
| CITADEL ADVISORS LLC | 214,716 | 1,040,666 | +825,950 | 0.00 | 0.02 | +0.02 | buy |
| Affinity Asset Advisors, LLC | 810,253 | 912,000 | +101,747 | 1.94 | 3.00 | +1.06 | buy |
| WASATCH ADVISORS LP | 1,236,753 | 858,067 | -378,686 | 0.10 | 0.10 | +0.00 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 650,000 | +650,000 | 0.00 | 0.18 | +0.18 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 642,190 | 623,404 | -18,786 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 966,453 | 603,133 | -363,320 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 374,249 | 599,623 | +225,374 | 0.00 | 0.01 | +0.01 | buy |
| SAMLYN CAPITAL, LLC | 0 | 583,490 | +583,490 | 0.00 | 0.21 | +0.21 | buy |
| NORGES BANK | 180,800 | 507,536 | +326,736 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 500,000 | +500,000 | 0.00 | 0.78 | +0.78 | buy |
| Parkman Healthcare Partners LLC | 250,000 | 474,679 | +224,679 | 0.45 | 1.35 | +0.90 | buy |
| GOLDMAN SACHS GROUP INC | 492,666 | 464,507 | -28,159 | 0.00 | 0.00 | +0.00 | sell |
| Ikarian Capital, LLC | 300,000 | 440,500 | +140,500 | 1.20 | 2.87 | +1.67 | buy |
| NORTHERN TRUST CORP | 404,010 | 438,089 | +34,079 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 262,162 | 432,289 | +170,127 | 0.03 | 0.07 | +0.04 | buy |
| Opaleye Management Inc. | 267,210 | 418,928 | +151,718 | 0.86 | 2.00 | +1.14 | buy |
| Invesco Ltd. | 312,910 | 365,298 | +52,388 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 334,972 | +334,972 | 0.00 | 0.03 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 179,300 | 324,000 | +144,700 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 165,603 | 320,552 | +154,949 | 0.03 | 0.07 | +0.04 | buy |
| ArrowMark Colorado Holdings LLC | 314,762 | 314,762 | 0 | 0.05 | 0.08 | +0.03 | hold |
| BESSEMER GROUP INC | 357,287 | 306,003 | -51,284 | 0.01 | 0.01 | +0.00 | sell |
| Woodline Partners LP | 0 | 301,887 | +301,887 | 0.00 | 0.06 | +0.06 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 279,000 | 290,000 | +11,000 | 0.00 | 0.00 | +0.00 | buy |
| WestHill Financial Advisors, Inc. | 283,333 | 283,333 | 0 | 1.02 | 1.43 | +0.41 | hold |
| Trexquant Investment LP | 212,879 | 238,582 | +25,703 | 0.06 | 0.08 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 434,413 | 224,908 | -209,505 | 0.03 | 0.02 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 97,176 | 221,327 | +124,151 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 159,218 | 209,136 | +49,918 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 203,273 | +203,273 | 0.00 | 1.25 | +1.25 | buy |
| JANE STREET GROUP, LLC | 56,714 | 200,097 | +143,383 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 0 | 174,393 | +174,393 | 0.00 | 0.35 | +0.35 | buy |
| Informed Momentum Co LLC | 0 | 174,077 | +174,077 | 0.00 | 0.59 | +0.59 | buy |
| Susquehanna Portfolio Strategies, LLC | 158,167 | 155,984 | -2,183 | 0.05 | 0.13 | +0.08 | sell |
| Integral Health Asset Management, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.31 | +0.31 | buy |
| Rafferty Asset Management, LLC | 211,425 | 137,316 | -74,109 | 0.01 | 0.01 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 128,671 | +128,671 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 168,942 | 118,563 | -50,379 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 79,770 | 117,128 | +37,358 | 0.03 | 0.07 | +0.04 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 160,293 | 115,341 | -44,952 | 0.01 | 0.01 | -0.00 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 108,799 | +108,799 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 22,194 | 103,199 | +81,005 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 0 | 99,200 | +99,200 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 112,779 | 98,171 | -14,608 | 0.00 | 0.00 | +0.00 | sell |
| Jasper Ridge Partners, L.P. | 95,711 | 95,711 | 0 | 0.04 | 0.06 | +0.02 | hold |
| Qube Research & Technologies Ltd | 0 | 95,424 | +95,424 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 177,900 | 89,500 | -88,400 | 0.01 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 77,771 | 88,781 | +11,010 | 0.00 | 0.00 | +0.00 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.49 | 0.69 | +0.21 | hold |
| FRANKLIN RESOURCES INC | 64,472 | 80,786 | +16,314 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 71,362 | 75,646 | +4,284 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 47,515 | 72,154 | +24,639 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 67,250 | 67,224 | -26 | 0.09 | 0.13 | +0.04 | sell |
| ALLIANCEBERNSTEIN L.P. | 46,460 | 63,320 | +16,860 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 237,104 | 62,298 | -174,806 | 0.01 | 0.01 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 211,316 | 60,888 | -150,428 | 0.01 | 0.00 | -0.00 | sell |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 187,743 | 60,084 | -127,659 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 88,260 | 59,853 | -28,407 | 0.03 | 0.03 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,529 | 57,191 | +6,662 | 0.00 | 0.00 | +0.00 | buy |
| Pennant Investors, LP | 56,800 | 56,800 | 0 | 0.23 | 0.32 | +0.09 | hold |
| Legal & General Group Plc | 6,742 | 50,880 | +44,138 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,786 | 49,974 | +45,188 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 105,864 | 46,804 | -59,060 | 0.00 | 0.00 | -0.00 | sell |
| Duquesne Family Office LLC | 44,200 | 44,200 | 0 | 0.02 | 0.03 | +0.02 | hold |
| FRED ALGER MANAGEMENT, LLC | 0 | 38,066 | +38,066 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 34,324 | 36,796 | +2,472 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 79,907 | 35,644 | -44,263 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 35,138 | +35,138 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 23,288 | 35,071 | +11,783 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 102,321 | 33,245 | -69,076 | 0.01 | 0.00 | -0.00 | sell |
| Mariner, LLC | 31,552 | 31,564 | +12 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 28,784 | +28,784 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 28,700 | +28,700 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 28,434 | +28,434 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 27,695 | +27,695 | 0.00 | 0.01 | +0.01 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 16,517 | 27,507 | +10,990 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 184,780 | 27,422 | -157,358 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 0 | 26,200 | +26,200 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 25,801 | +25,801 | 0.00 | 0.04 | +0.04 | buy |
| PROFUND ADVISORS LLC | 33,060 | 25,588 | -7,472 | 0.02 | 0.02 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 16,331 | 25,372 | +9,041 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 21,167 | 25,349 | +4,182 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 24,882 | +24,882 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 0 | 24,552 | +24,552 | 0.00 | 0.01 | +0.01 | buy |