| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 1,125,552 | 2,000,000 | +874,448 | 0.95 | 1.20 | +0.24 | buy |
| PERCEPTIVE ADVISORS LLC | 297,553 | 1,096,985 | +799,432 | 0.12 | 0.46 | +0.34 | buy |
| Nikko Asset Management Americas, Inc. | 755,970 | 1,389,274 | +633,304 | 0.12 | 0.16 | +0.04 | buy |
| Deep Track Capital, LP | 5,500,000 | 6,064,910 | +564,910 | 2.12 | 2.22 | +0.11 | buy |
| Kynam Capital Management, LP | 800,000 | 1,173,605 | +373,605 | 0.81 | 1.44 | +0.63 | buy |
| Affinity Asset Advisors, LLC | 810,669 | 967,620 | +156,951 | 0.92 | 1.51 | +0.59 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,913,368 | 3,033,844 | +120,476 | 0.00 | 0.00 | -0.00 | buy |
| Cinctive Capital Management LP | 38,770 | 116,133 | +77,363 | 0.04 | 0.07 | +0.03 | buy |
| Susquehanna Portfolio Strategies, LLC | 10,550 | 70,670 | +60,120 | 0.05 | 0.02 | -0.04 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 205,100 | 257,816 | +52,716 | 0.06 | 0.07 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 2,428,283 | 2,473,956 | +45,673 | 0.02 | 0.02 | -0.00 | buy |
| Integral Health Asset Management, LLC | 275,000 | 310,000 | +35,000 | 0.35 | 0.32 | -0.02 | buy |
| NEOS Investment Management LLC | 59,146 | 81,112 | +21,966 | 0.01 | 0.01 | -0.00 | buy |
| TEMA ETFS LLC | 59,146 | 81,112 | +21,966 | 0.21 | 0.25 | +0.04 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 14,249 | 26,406 | +12,157 | 0.02 | 0.03 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 21,200 | 31,200 | +10,000 | 0.05 | 0.06 | +0.01 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 926 | 7,041 | +6,115 | 0.00 | 0.01 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 43,006 | 43,544 | +538 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 15,222 | 15,312 | +90 | 0.02 | 0.02 | -0.00 | buy |
| Woodline Partners LP | 100,204 | 100,271 | +67 | 0.01 | 0.01 | -0.00 | buy |
| J.Safra Asset Management Corp | 97 | 158 | +61 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 7,986 | 7,862 | -124 | 0.03 | 0.03 | +0.00 | sell |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 16,000 | 12,400 | -3,600 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 23,187 | 16,433 | -6,754 | 0.01 | 0.01 | -0.01 | sell |
| ARK Investment Management LLC | 1,590,910 | 1,575,032 | -15,878 | 0.19 | 0.13 | -0.06 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 232,000 | 210,000 | -22,000 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 145,474 | 117,282 | -28,192 | 0.02 | 0.04 | +0.01 | sell |
| Commodore Capital LP | 3,978,907 | 3,948,653 | -30,254 | 3.48 | 3.17 | -0.31 | sell |
| Rafferty Asset Management, LLC | 110,082 | 75,723 | -34,359 | 0.01 | 0.00 | -0.00 | sell |
| Patient Square Capital LP | 447,296 | 412,296 | -35,000 | 2.20 | 1.69 | -0.51 | sell |
| Artisan Partners Limited Partnership | 638,609 | 580,749 | -57,860 | 0.01 | 0.01 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 249,336 | 185,000 | -64,336 | 0.34 | 0.27 | -0.07 | sell |
| WASATCH ADVISORS LP | 569,797 | 486,936 | -82,861 | 0.04 | 0.03 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 350,420 | 228,271 | -122,149 | 0.49 | 0.30 | -0.19 | sell |
| Redmile Group, LLC | 4,051,927 | 3,732,888 | -319,039 | 4.55 | 4.53 | -0.02 | sell |
| Candriam S.C.A. | 588,931 | 262,384 | -326,547 | 0.04 | 0.02 | -0.03 | sell |
| Boxer Capital Management, LLC | 563,067 | 175,000 | -388,067 | 2.01 | 1.00 | -1.01 | sell |