| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 8,925,642 | 8,770,349 | -155,293 | 0.00 | 0.00 | +0.00 | sell |
| Vestal Point Capital, LP | 6,500,000 | 8,050,000 | +1,550,000 | 2.82 | 4.56 | +1.75 | buy |
| Deep Track Capital, LP | 6,345,244 | 7,736,455 | +1,391,211 | 2.03 | 2.76 | +0.74 | buy |
| Rubric Capital Management LP | 2,473,885 | 7,227,778 | +4,753,893 | 0.47 | 1.61 | +1.14 | buy |
| FMR LLC | 5,541,271 | 5,485,215 | -56,056 | 0.00 | 0.01 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,290,233 | 5,436,587 | +2,146,354 | 0.01 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 4,931,999 | 4,762,484 | -169,515 | 0.00 | 0.01 | +0.00 | sell |
| STATE STREET CORP | 5,141,195 | 4,677,244 | -463,951 | 0.00 | 0.00 | +0.00 | sell |
| BAKER BROS. ADVISORS LP | 4,658,556 | 4,658,556 | 0 | 0.41 | 0.57 | +0.15 | hold |
| PERCEPTIVE ADVISORS LLC | 3,710,877 | 4,320,422 | +609,545 | 1.14 | 1.63 | +0.49 | buy |
| Redmile Group, LLC | 7,732,808 | 4,073,787 | -3,659,021 | 7.94 | 6.64 | -1.30 | sell |
| GENERAL ATLANTIC, L.P. | 4,101,865 | 3,032,185 | -1,069,680 | 2.96 | 2.53 | -0.43 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,520,229 | 2,537,291 | +17,062 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 2,726,138 | 2,351,232 | -374,906 | 0.04 | 0.05 | +0.01 | sell |
| ARK Investment Management LLC | 1,721,135 | 1,793,196 | +72,061 | 0.21 | 0.28 | +0.07 | buy |
| Capital World Investors | 893,327 | 1,787,916 | +894,589 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,343,700 | 1,477,019 | +133,319 | 0.01 | 0.02 | +0.01 | buy |
| Soleus Capital Management, L.P. | 938,163 | 1,465,163 | +527,000 | 0.59 | 1.22 | +0.64 | buy |
| DIMENSIONAL FUND ADVISORS LP | 780,696 | 1,431,317 | +650,621 | 0.00 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,297,893 | 1,297,893 | 0 | 0.33 | 0.42 | +0.09 | hold |
| BRAIDWELL LP | 1,750,766 | 1,286,769 | -463,997 | 0.91 | 1.15 | +0.25 | sell |
| Kynam Capital Management, LP | 1,194,757 | 1,194,757 | 0 | 1.18 | 1.60 | +0.43 | hold |
| Woodline Partners LP | 925,444 | 1,064,006 | +138,562 | 0.05 | 0.08 | +0.03 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 1,181,146 | 983,462 | -197,684 | 0.01 | 0.01 | +0.00 | sell |
| Nikko Asset Management Americas, Inc. | 1,181,146 | 983,462 | -197,684 | 0.26 | 0.31 | +0.05 | sell |
| Affinity Asset Advisors, LLC | 967,620 | 967,620 | 0 | 0.88 | 1.15 | +0.27 | hold |
| UBS Group AG | 976,362 | 917,117 | -59,245 | 0.00 | 0.00 | +0.00 | sell |
| NORTHERN TRUST CORP | 854,466 | 876,070 | +21,604 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 802,153 | 842,089 | +39,936 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 833,296 | +833,296 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 924,039 | 833,296 | -90,743 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 812,601 | 825,833 | +13,232 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,318,659 | 813,589 | -505,070 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 561,250 | 724,508 | +163,258 | 0.18 | 0.31 | +0.13 | buy |
| Rhenman & Partners Asset Management AB | 313,500 | 684,250 | +370,750 | 0.60 | 1.57 | +0.97 | buy |
| Handelsbanken Fonder AB | 547,000 | 633,000 | +86,000 | 0.03 | 0.04 | +0.02 | buy |
| RAYMOND JAMES FINANCIAL INC | 353,733 | 593,262 | +239,529 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 524,098 | +524,098 | 0.00 | 0.68 | +0.68 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 477,141 | +477,141 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 477,410 | 389,384 | -88,026 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 534,259 | 377,902 | -156,357 | 0.04 | 0.04 | -0.00 | sell |
| Fisher Asset Management, LLC | 384,831 | 369,465 | -15,366 | 0.00 | 0.00 | +0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 620,820 | 363,603 | -257,217 | 0.04 | 0.03 | -0.01 | sell |
| FIRST TRUST ADVISORS LP | 0 | 360,848 | +360,848 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 223,363 | 340,578 | +117,215 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 321,360 | 334,138 | +12,778 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 314,762 | 314,762 | 0 | 0.13 | 0.32 | +0.19 | hold |
| ADAR1 Capital Management, LLC | 56,070 | 313,236 | +257,166 | 0.05 | 0.36 | +0.30 | buy |
| BESSEMER GROUP INC | 306,003 | 306,003 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Bank of New York Mellon Corp | 295,345 | 272,640 | -22,705 | 0.00 | 0.00 | +0.00 | sell |
| EcoR1 Capital, LLC | 0 | 270,000 | +270,000 | 0.00 | 0.32 | +0.32 | buy |
| Foresite Capital Management V, LLC | 265,000 | 265,000 | 0 | 1.52 | 1.77 | +0.26 | hold |
| Susquehanna Portfolio Strategies, LLC | 107,663 | 232,924 | +125,261 | 0.02 | 0.09 | +0.07 | buy |
| WestHill Financial Advisors, Inc. | 228,333 | 218,333 | -10,000 | 0.68 | 0.90 | +0.23 | sell |
| HighVista Strategies LLC | 226,546 | 203,739 | -22,807 | 0.97 | 1.13 | +0.16 | sell |
| Y-Intercept (Hong Kong) Ltd | 55,138 | 192,434 | +137,296 | 0.02 | 0.09 | +0.08 | buy |
| TD ASSET MANAGEMENT INC | 189,250 | 190,344 | +1,094 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 81,841 | 184,648 | +102,807 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 344,203 | 184,551 | -159,652 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 16,406 | 179,464 | +163,058 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 203,609 | 178,049 | -25,560 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 89,518 | 170,788 | +81,270 | 0.02 | 0.04 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 179,177 | 168,857 | -10,320 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 2,295,024 | 151,453 | -2,143,571 | 0.01 | 0.00 | -0.01 | sell |
| PRUDENTIAL FINANCIAL INC | 44,200 | 145,170 | +100,970 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 138,122 | +138,122 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 157,350 | 135,104 | -22,246 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 150,000 | 124,500 | -25,500 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 123,367 | 123,072 | -295 | 0.00 | 0.00 | +0.00 | sell |
| DIADEMA PARTNERS LP | 0 | 121,539 | +121,539 | 0.00 | 1.04 | +1.04 | buy |
| Burkehill Global Management, LP | 118,972 | 118,972 | 0 | 0.09 | 0.10 | +0.01 | hold |
| ALLIANCEBERNSTEIN L.P. | 98,190 | 111,290 | +13,100 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 485,212 | 108,757 | -376,455 | 0.01 | 0.00 | -0.01 | sell |
| SEI INVESTMENTS CO | 82,108 | 107,510 | +25,402 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 56,137 | 103,573 | +47,436 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 100,000 | 100,000 | 0 | 0.20 | 0.18 | -0.02 | hold |
| Phocas Financial Corp. | 0 | 99,589 | +99,589 | 0.00 | 0.34 | +0.34 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 40,928 | 97,567 | +56,639 | 0.00 | 0.00 | +0.00 | buy |
| Jasper Ridge Partners, L.P. | 95,711 | 95,711 | 0 | 0.03 | 0.05 | +0.02 | hold |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 90,000 | 90,000 | 0 | 0.02 | 0.03 | +0.01 | hold |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 81,760 | 89,885 | +8,125 | 0.10 | 0.14 | +0.04 | buy |
| XTX Topco Ltd | 40,386 | 87,537 | +47,151 | 0.01 | 0.03 | +0.02 | buy |
| Man Group plc | 0 | 85,583 | +85,583 | 0.00 | 0.00 | +0.00 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.50 | 0.54 | +0.04 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 77,897 | 77,460 | -437 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asset Management, L.P. | 449,106 | 73,069 | -376,037 | 0.01 | 0.00 | -0.01 | sell |
| Legal & General Group Plc | 70,765 | 72,026 | +1,261 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 99,042 | 69,327 | -29,715 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 149,523 | 68,360 | -81,163 | 0.01 | 0.00 | -0.01 | sell |
| Swedbank AB | 0 | 65,000 | +65,000 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 64,661 | +64,661 | 0.00 | 0.02 | +0.02 | buy |
| WESBANCO BANK INC | 0 | 62,700 | +62,700 | 0.00 | 0.04 | +0.04 | buy |
| Polymer Capital Management (HK) LTD | 58,898 | 58,898 | 0 | 0.13 | 0.15 | +0.02 | hold |
| MetLife Investment Management, LLC | 55,948 | 56,808 | +860 | 0.00 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 31,595 | 49,780 | +18,185 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 50,357 | 48,692 | -1,665 | 0.00 | 0.00 | +0.00 | sell |
| Mariner, LLC | 26,238 | 44,716 | +18,478 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 81,455 | 38,080 | -43,375 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 66,993 | 35,234 | -31,759 | 0.04 | 0.02 | -0.01 | sell |
| SG Americas Securities, LLC | 18,974 | 34,655 | +15,681 | 0.00 | 0.00 | +0.00 | buy |