| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 4,423,616 | 4,280,981 | -142,635 | 5.58 | 5.67 | +0.09 | sell |
| VANGUARD GROUP INC | 3,625,014 | 4,011,814 | +386,800 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 3,882,125 | 3,882,125 | 0 | 1.04 | 0.90 | -0.13 | hold |
| Deep Track Capital, LP | 3,991,500 | 3,868,104 | -123,396 | 2.49 | 2.77 | +0.29 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 3,201,865 | 3,482,105 | +280,240 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,835,119 | 3,068,961 | +233,842 | 0.01 | 0.01 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 2,189,192 | 2,548,091 | +358,899 | 0.03 | 0.03 | +0.01 | buy |
| STATE STREET CORP | 2,708,533 | 2,371,271 | -337,262 | 0.00 | 0.00 | -0.00 | sell |
| ARK Investment Management LLC | 2,323,332 | 2,216,365 | -106,967 | 0.43 | 0.46 | +0.03 | sell |
| MORGAN STANLEY | 1,989,700 | 1,878,564 | -111,136 | 0.00 | 0.00 | -0.00 | sell |
| Pictet Asset Management Holding SA | 1,173,518 | 1,788,530 | +615,012 | 0.03 | 0.04 | +0.02 | buy |
| Commodore Capital LP | 0 | 1,650,000 | +1,650,000 | 0.00 | 2.32 | +2.32 | buy |
| CITADEL ADVISORS LLC | 1,040,666 | 1,531,205 | +490,539 | 0.02 | 0.04 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,321,734 | 1,448,040 | +126,306 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,283,108 | 1,285,632 | +2,524 | 0.26 | 0.25 | -0.01 | buy |
| Soleus Capital Management, L.P. | 2,055,916 | 1,065,834 | -990,082 | 3.78 | 1.99 | -1.79 | sell |
| Candriam S.C.A. | 1,164,246 | 1,061,959 | -102,287 | 0.15 | 0.14 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 912,000 | 860,399 | -51,601 | 3.00 | 3.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 1,048,394 | 854,682 | -193,712 | 0.01 | 0.01 | -0.00 | sell |
| WASATCH ADVISORS LP | 858,067 | 708,377 | -149,690 | 0.10 | 0.08 | -0.02 | sell |
| FMR LLC | 75,646 | 586,902 | +511,256 | 0.00 | 0.00 | +0.00 | buy |
| SAMLYN CAPITAL, LLC | 583,490 | 568,264 | -15,226 | 0.21 | 0.21 | -0.00 | sell |
| NORTHERN TRUST CORP | 438,089 | 566,855 | +128,766 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 0 | 553,251 | +553,251 | 0.00 | 0.01 | +0.01 | buy |
| Nikko Asset Management Americas, Inc. | 0 | 552,602 | +552,602 | 0.00 | 0.14 | +0.14 | buy |
| GOLDMAN SACHS GROUP INC | 464,507 | 513,221 | +48,714 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 623,404 | 511,720 | -111,684 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 603,133 | 501,569 | -101,564 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 474,679 | 438,971 | -35,708 | 1.35 | 1.26 | -0.09 | sell |
| Vestal Point Capital, LP | 500,000 | 425,000 | -75,000 | 0.78 | 0.75 | -0.02 | sell |
| Opaleye Management Inc. | 418,928 | 420,000 | +1,072 | 2.00 | 1.57 | -0.42 | buy |
| Invesco Ltd. | 365,298 | 413,340 | +48,042 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 432,289 | 355,602 | -76,687 | 0.07 | 0.06 | -0.01 | sell |
| LORD, ABBETT & CO. LLC | 0 | 350,640 | +350,640 | 0.00 | 0.03 | +0.03 | buy |
| Woodline Partners LP | 301,887 | 336,879 | +34,992 | 0.06 | 0.06 | +0.00 | buy |
| Patient Square Capital LP | 0 | 325,789 | +325,789 | 0.00 | 2.72 | +2.72 | buy |
| NORGES BANK | 507,536 | 318,800 | -188,736 | 0.00 | 0.00 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 314,762 | 314,762 | 0 | 0.08 | 0.09 | +0.01 | hold |
| BESSEMER GROUP INC | 306,003 | 306,053 | +50 | 0.01 | 0.01 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 174,393 | 300,000 | +125,607 | 0.35 | 0.55 | +0.20 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 290,000 | 290,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ikarian Capital, LLC | 440,500 | 260,000 | -180,500 | 2.87 | 1.81 | -1.05 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 324,000 | 246,400 | -77,600 | 0.01 | 0.01 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 334,972 | 241,048 | -93,924 | 0.03 | 0.02 | -0.01 | sell |
| WestHill Financial Advisors, Inc. | 283,333 | 238,333 | -45,000 | 1.43 | 1.20 | -0.23 | sell |
| MILLENNIUM MANAGEMENT LLC | 599,623 | 221,718 | -377,905 | 0.01 | 0.00 | -0.01 | sell |
| Qube Research & Technologies Ltd | 95,424 | 214,728 | +119,304 | 0.00 | 0.01 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 203,273 | 203,015 | -258 | 1.25 | 1.37 | +0.12 | sell |
| Integral Health Asset Management, LLC | 150,000 | 200,000 | +50,000 | 0.31 | 0.53 | +0.22 | buy |
| Ensign Peak Advisors, Inc | 35,644 | 180,000 | +144,356 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 209,136 | 175,266 | -33,870 | 0.00 | 0.00 | -0.00 | sell |
| Informed Momentum Co LLC | 174,077 | 174,760 | +683 | 0.59 | 0.59 | -0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 38,066 | 166,014 | +127,948 | 0.00 | 0.02 | +0.01 | buy |
| Trexquant Investment LP | 238,582 | 159,261 | -79,321 | 0.08 | 0.05 | -0.03 | sell |
| JANE STREET GROUP, LLC | 200,097 | 157,619 | -42,478 | 0.00 | 0.01 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 155,984 | 154,044 | -1,940 | 0.13 | 0.24 | +0.10 | sell |
| Allspring Global Investments Holdings, LLC | 0 | 140,273 | +140,273 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 221,327 | 138,124 | -83,203 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 128,671 | 128,524 | -147 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 72,154 | 128,344 | +56,190 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 125,000 | +125,000 | 0.00 | 0.02 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 80,786 | 123,101 | +42,315 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 59,853 | 113,838 | +53,985 | 0.03 | 0.06 | +0.03 | buy |
| Swiss National Bank | 99,200 | 106,900 | +7,700 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 115,341 | 106,861 | -8,480 | 0.01 | 0.01 | +0.00 | sell |
| Cinctive Capital Management LP | 0 | 105,228 | +105,228 | 0.00 | 0.14 | +0.14 | buy |
| UBS Group AG | 118,563 | 102,866 | -15,697 | 0.00 | 0.00 | -0.00 | sell |
| Jasper Ridge Partners, L.P. | 95,711 | 95,711 | 0 | 0.06 | 0.06 | -0.00 | hold |
| Rafferty Asset Management, LLC | 137,316 | 93,593 | -43,723 | 0.01 | 0.01 | -0.00 | sell |
| RHUMBLINE ADVISERS | 88,781 | 90,918 | +2,137 | 0.00 | 0.00 | +0.00 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.69 | 0.81 | +0.12 | hold |
| D. E. Shaw & Co., Inc. | 0 | 72,840 | +72,840 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 98,171 | 69,415 | -28,756 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 117,128 | 69,134 | -47,994 | 0.07 | 0.05 | -0.03 | sell |
| JPMORGAN CHASE & CO | 36,796 | 68,148 | +31,352 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 28,784 | 67,280 | +38,496 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 65,459 | +65,459 | 0.00 | 0.03 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 63,320 | 63,320 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 50,880 | 59,899 | +9,019 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 89,500 | 59,100 | -30,400 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 49,974 | 52,454 | +2,480 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 60,888 | 50,709 | -10,179 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 27,422 | 49,593 | +22,171 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 21,296 | 46,920 | +25,624 | 0.00 | 0.00 | +0.00 | buy |
| Duquesne Family Office LLC | 44,200 | 44,200 | 0 | 0.03 | 0.03 | +0.00 | hold |
| ROYAL BANK OF CANADA | 5,790 | 43,248 | +37,458 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 42,204 | +42,204 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 25,349 | 40,803 | +15,454 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 28,434 | 40,434 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29,575 | 38,619 | +9,044 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 35,138 | 37,096 | +1,958 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 35,071 | 35,239 | +168 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 320,552 | 34,613 | -285,939 | 0.07 | 0.01 | -0.07 | sell |
| Corebridge Financial, Inc. | 32,557 | 34,137 | +1,580 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 31,564 | 31,795 | +231 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,942 | 30,383 | +7,441 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 27,695 | 30,024 | +2,329 | 0.01 | 0.01 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 27,000 | +27,000 | 0.00 | 0.01 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 33,245 | 26,544 | -6,701 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 26,200 | 26,200 | 0 | 0.00 | 0.00 | +0.00 | hold |