| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 2,189,192 | 2,548,091 | +358,899 | 0.03 | 0.03 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,835,119 | 3,068,961 | +233,842 | 0.01 | 0.01 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 38,066 | 166,014 | +127,948 | 0.00 | 0.02 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 174,393 | 300,000 | +125,607 | 0.35 | 0.55 | +0.20 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 59,853 | 113,838 | +53,985 | 0.03 | 0.06 | +0.03 | buy |
| Integral Health Asset Management, LLC | 150,000 | 200,000 | +50,000 | 0.31 | 0.53 | +0.22 | buy |
| Woodline Partners LP | 301,887 | 336,879 | +34,992 | 0.06 | 0.06 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 33,245 | 26,544 | +6,701 | 0.00 | 0.00 | 0.00 | sell |
| PROFUND ADVISORS LLC | 25,588 | 19,038 | +6,550 | 0.02 | 0.02 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 6,969 | 12,388 | +5,419 | 0.02 | 0.03 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,283,108 | 1,285,632 | +2,524 | 0.26 | 0.25 | -0.01 | buy |
| Opaleye Management Inc. | 418,928 | 420,000 | +1,072 | 2.00 | 1.57 | -0.42 | buy |
| Informed Momentum Co LLC | 174,077 | 174,760 | +683 | 0.59 | 0.59 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 5,411 | 5,512 | +101 | 0.06 | 0.06 | +0.00 | buy |
| BESSEMER GROUP INC | 306,003 | 306,053 | +50 | 0.01 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 203,273 | 203,015 | -258 | 1.25 | 1.37 | +0.12 | sell |
| NATIXIS | 3,629 | 3,221 | -408 | 0.00 | 0.00 | -0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 155,984 | 154,044 | -1,940 | 0.13 | 0.24 | +0.10 | sell |
| Avalon Trust Co | 7,056 | 4,150 | -2,906 | 0.01 | 0.01 | -0.00 | sell |
| SAMLYN CAPITAL, LLC | 583,490 | 568,264 | -15,226 | 0.20 | 0.19 | -0.01 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 98,171 | 69,415 | -28,756 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 474,679 | 438,971 | -35,708 | 1.35 | 1.26 | -0.09 | sell |
| Rafferty Asset Management, LLC | 137,316 | 93,593 | -43,723 | 0.01 | 0.01 | -0.00 | sell |
| WestHill Financial Advisors, Inc. | 283,333 | 238,333 | -45,000 | 1.43 | 1.20 | -0.23 | sell |
| Affinity Asset Advisors, LLC | 912,000 | 860,399 | -51,601 | 3.00 | 3.00 | +0.00 | sell |
| Vestal Point Capital, LP | 500,000 | 425,000 | -75,000 | 0.78 | 0.75 | -0.02 | sell |
| Candriam S.C.A. | 1,164,246 | 1,061,959 | -102,287 | 0.15 | 0.14 | -0.01 | sell |
| ARK Investment Management LLC | 2,323,332 | 2,216,365 | -106,967 | 0.43 | 0.46 | +0.03 | sell |
| Deep Track Capital, LP | 3,991,500 | 3,868,104 | -123,396 | 2.49 | 2.77 | +0.29 | sell |
| Redmile Group, LLC | 4,423,616 | 4,280,981 | -142,635 | 5.58 | 5.67 | +0.09 | sell |
| WASATCH ADVISORS LP | 858,067 | 708,377 | -149,690 | 0.10 | 0.08 | -0.02 | sell |
| Ikarian Capital, LLC | 440,500 | 260,000 | -180,500 | 2.87 | 1.81 | -1.05 | sell |
| Soleus Capital Management, L.P. | 2,055,916 | 1,065,834 | -990,082 | 3.78 | 1.99 | -1.79 | sell |