| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Commodore Capital LP | 0 | 1,650,000 | +1,650,000 | 0.00 | 2.32 | +2.32 | buy |
| Pictet Asset Management Holding SA | 1,173,518 | 1,788,530 | +615,012 | 0.03 | 0.04 | +0.02 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 0 | 553,251 | +553,251 | 0.00 | 0.01 | +0.01 | buy |
| Nikko Asset Management Americas, Inc. | 0 | 552,602 | +552,602 | 0.00 | 0.14 | +0.14 | buy |
| FMR LLC | 75,646 | 586,902 | +511,256 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,040,666 | 1,531,205 | +490,539 | 0.02 | 0.04 | +0.01 | buy |
| VANGUARD GROUP INC | 3,625,014 | 4,011,814 | +386,800 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 2,189,192 | 2,548,091 | +358,899 | 0.03 | 0.03 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 0 | 350,640 | +350,640 | 0.00 | 0.03 | +0.03 | buy |
| Patient Square Capital LP | 0 | 325,789 | +325,789 | 0.00 | 2.72 | +2.72 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,201,865 | 3,482,105 | +280,240 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,835,119 | 3,068,961 | +233,842 | 0.01 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 35,644 | 180,000 | +144,356 | 0.00 | 0.01 | +0.01 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 140,273 | +140,273 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 438,089 | 566,855 | +128,766 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 38,066 | 166,014 | +127,948 | 0.00 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,321,734 | 1,448,040 | +126,306 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 174,393 | 300,000 | +125,607 | 0.35 | 0.55 | +0.20 | buy |
| Hudson Bay Capital Management LP | 0 | 125,000 | +125,000 | 0.00 | 0.02 | +0.02 | buy |
| Qube Research & Technologies Ltd | 95,424 | 214,728 | +119,304 | 0.00 | 0.01 | +0.01 | buy |
| Cinctive Capital Management LP | 0 | 105,228 | +105,228 | 0.00 | 0.14 | +0.14 | buy |
| D. E. Shaw & Co., Inc. | 0 | 72,840 | +72,840 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 65,459 | +65,459 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 72,154 | 128,344 | +56,190 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 59,853 | 113,838 | +53,985 | 0.03 | 0.06 | +0.03 | buy |
| Integral Health Asset Management, LLC | 150,000 | 200,000 | +50,000 | 0.31 | 0.53 | +0.22 | buy |
| GOLDMAN SACHS GROUP INC | 464,507 | 513,221 | +48,714 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 365,298 | 413,340 | +48,042 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 80,786 | 123,101 | +42,315 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 42,204 | +42,204 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 28,784 | 67,280 | +38,496 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 5,790 | 43,248 | +37,458 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 301,887 | 336,879 | +34,992 | 0.06 | 0.06 | +0.00 | buy |
| JPMORGAN CHASE & CO | 36,796 | 68,148 | +31,352 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 27,000 | +27,000 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 21,296 | 46,920 | +25,624 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 23,578 | +23,578 | 0.00 | 0.06 | +0.06 | buy |
| CITIGROUP INC | 27,422 | 49,593 | +22,171 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 21,540 | +21,540 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 18,901 | +18,901 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 25,349 | 40,803 | +15,454 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 15,388 | +15,388 | 0.00 | 0.02 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 28,434 | 40,434 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 0 | 10,742 | +10,742 | 0.00 | 0.00 | +0.00 | buy |
| EP Wealth Advisors, LLC | 0 | 10,693 | +10,693 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29,575 | 38,619 | +9,044 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 50,880 | 59,899 | +9,019 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 0 | 8,000 | +8,000 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 99,200 | 106,900 | +7,700 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,942 | 30,383 | +7,441 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 10,037 | 15,871 | +5,834 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,969 | 12,388 | +5,419 | 0.02 | 0.03 | +0.01 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 375 | 4,494 | +4,119 | 0.00 | 0.00 | -0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 4,050 | +4,050 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 11,071 | 13,731 | +2,660 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,283,108 | 1,285,632 | +2,524 | 0.26 | 0.25 | -0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 49,974 | 52,454 | +2,480 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 65 | 2,500 | +2,435 | 0.00 | 0.02 | +0.02 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 27,695 | 30,024 | +2,329 | 0.01 | 0.01 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 19,737 | 22,056 | +2,319 | 0.04 | 0.04 | +0.00 | buy |
| RHUMBLINE ADVISERS | 88,781 | 90,918 | +2,137 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 35,138 | 37,096 | +1,958 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 14,114 | 15,764 | +1,650 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 32,557 | 34,137 | +1,580 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 6,146 | 7,458 | +1,312 | 0.02 | 0.01 | -0.00 | buy |
| Opaleye Management Inc. | 418,928 | 420,000 | +1,072 | 2.00 | 1.57 | -0.42 | buy |
| Smartleaf Asset Management LLC | 17 | 781 | +764 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 174,077 | 174,760 | +683 | 0.59 | 0.59 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,771 | 2,330 | +559 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 5,929 | 6,468 | +539 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,671 | 2,182 | +511 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 24,552 | 24,975 | +423 | 0.01 | 0.01 | -0.00 | buy |
| TD Waterhouse Canada Inc. | 0 | 282 | +282 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 31,564 | 31,795 | +231 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 22,048 | 22,259 | +211 | 0.01 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 35,071 | 35,239 | +168 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 4,566 | 4,701 | +135 | 0.01 | 0.01 | -0.00 | buy |
| CWM, LLC | 142 | 273 | +131 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 5,411 | 5,512 | +101 | 0.06 | 0.06 | +0.00 | buy |
| Daiwa Securities Group Inc. | 152 | 245 | +93 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 20,185 | 20,268 | +83 | 0.00 | 0.00 | +0.00 | buy |
| FOURPATH CAPITAL MANAGEMENT, LLC | 0 | 67 | +67 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 623 | 682 | +59 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 306,003 | 306,053 | +50 | 0.01 | 0.01 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 30 | 60 | +30 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 24 | +24 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 9 | 14 | +5 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 4,876 | 4,876 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 63,320 | 63,320 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 3,882,125 | 3,882,125 | 0 | 1.04 | 0.90 | -0.13 | hold |
| JANUS HENDERSON GROUP PLC | 26,200 | 26,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BBR PARTNERS, LLC | 20,988 | 20,988 | 0 | 0.04 | 0.04 | +0.00 | hold |
| Jasper Ridge Partners, L.P. | 95,711 | 95,711 | 0 | 0.06 | 0.06 | -0.00 | hold |
| SIGNATUREFD, LLC | 570 | 570 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ArrowMark Colorado Holdings LLC | 314,762 | 314,762 | 0 | 0.08 | 0.09 | +0.01 | hold |
| Duquesne Family Office LLC | 44,200 | 44,200 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Arax Advisory Partners | 130 | 130 | 0 | 0.00 | 0.00 | -0.00 | hold |