| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 10,442,467 | 8,887,537 | -1,554,930 | 0.01 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 6,808,698 | 6,762,586 | -46,112 | 0.00 | 0.00 | -0.00 | sell |
| Deep Track Capital, LP | 6,064,910 | 6,057,024 | -7,886 | 2.22 | 1.56 | -0.66 | sell |
| VANGUARD GROUP INC | 4,465,507 | 4,488,776 | +23,269 | 0.00 | 0.00 | -0.00 | buy |
| BAKER BROS. ADVISORS LP | 3,882,125 | 3,882,125 | 0 | 0.43 | 0.26 | -0.17 | hold |
| Commodore Capital LP | 3,948,653 | 3,780,055 | -168,598 | 3.17 | 1.71 | -1.47 | sell |
| Redmile Group, LLC | 3,732,888 | 3,678,394 | -54,494 | 4.53 | 3.31 | -1.22 | sell |
| Vestal Point Capital, LP | 2,000,000 | 3,475,000 | +1,475,000 | 1.20 | 1.46 | +0.26 | buy |
| Point72 Asset Management, L.P. | 3,703,594 | 2,871,497 | -832,097 | 0.10 | 0.06 | -0.04 | sell |
| STATE STREET CORP | 2,532,154 | 2,862,387 | +330,233 | 0.00 | 0.00 | -0.00 | buy |
| Soleus Capital Management, L.P. | 2,422,833 | 2,422,833 | 0 | 1.91 | 1.20 | -0.71 | hold |
| MORGAN STANLEY | 2,167,121 | 2,260,746 | +93,625 | 0.00 | 0.00 | -0.00 | buy |
| Kynam Capital Management, LP | 1,173,605 | 2,168,605 | +995,000 | 1.44 | 1.49 | +0.05 | buy |
| Pictet Asset Management Holding SA | 1,998,634 | 1,980,540 | -18,094 | 0.02 | 0.02 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,881,960 | 1,882,682 | +722 | 0.00 | 0.00 | -0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 1,391,638 | 1,557,479 | +165,841 | 0.01 | 0.01 | -0.00 | buy |
| Nikko Asset Management Americas, Inc. | 1,389,274 | 1,557,479 | +168,205 | 0.16 | 0.14 | -0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 927,558 | 1,523,959 | +596,401 | 0.01 | 0.01 | +0.00 | buy |
| ARK Investment Management LLC | 1,575,032 | 1,510,404 | -64,628 | 0.13 | 0.08 | -0.05 | sell |
| DEUTSCHE BANK AG\ | 368,878 | 1,438,859 | +1,069,981 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,096,985 | 1,416,149 | +319,164 | 0.47 | 0.38 | -0.09 | buy |
| T. Rowe Price Investment Management, Inc. | 2,473,956 | 1,197,415 | -1,276,541 | 0.02 | 0.01 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,033,844 | 1,099,093 | -1,934,751 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 967,620 | 967,620 | 0 | 1.63 | 0.83 | -0.80 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 607,127 | 864,380 | +257,253 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 356,742 | 716,535 | +359,793 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 653,533 | 680,009 | +26,476 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 584,519 | 622,299 | +37,780 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 1,589,035 | 565,305 | -1,023,730 | 0.02 | 0.00 | -0.01 | sell |
| ALGERT GLOBAL LLC | 114,499 | 563,837 | +449,338 | 0.03 | 0.09 | +0.06 | buy |
| Handelsbanken Fonder AB | 280,000 | 520,000 | +240,000 | 0.01 | 0.02 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 327,211 | 481,054 | +153,843 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 412,296 | 437,237 | +24,941 | 1.69 | 1.08 | -0.61 | buy |
| DIMENSIONAL FUND ADVISORS LP | 427,071 | 430,962 | +3,891 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 1,589,040 | 362,546 | -1,226,494 | 0.00 | 0.00 | -0.00 | sell |
| Integral Health Asset Management, LLC | 310,000 | 350,000 | +40,000 | 0.33 | 0.24 | -0.09 | buy |
| Rhenman & Partners Asset Management AB | 185,000 | 347,500 | +162,500 | 0.27 | 0.36 | +0.09 | buy |
| Cubist Systematic Strategies, LLC | 0 | 327,952 | +327,952 | 0.00 | 0.04 | +0.04 | buy |
| ArrowMark Colorado Holdings LLC | 314,762 | 314,762 | 0 | 0.06 | 0.05 | -0.01 | hold |
| WASATCH ADVISORS LP | 486,936 | 313,889 | -173,047 | 0.03 | 0.02 | -0.01 | sell |
| BESSEMER GROUP INC | 306,003 | 306,003 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Candriam S.C.A. | 262,384 | 262,384 | 0 | 0.02 | 0.01 | -0.00 | hold |
| JANE STREET GROUP, LLC | 0 | 258,651 | +258,651 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,465,053 | 255,790 | -1,209,263 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 246,788 | +246,788 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 257,816 | 246,743 | -11,073 | 0.07 | 0.05 | -0.02 | sell |
| BARCLAYS PLC | 254,870 | 245,095 | -9,775 | 0.00 | 0.00 | -0.00 | sell |
| Ensign Peak Advisors, Inc | 230,828 | 230,828 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bank of New York Mellon Corp | 224,125 | 228,758 | +4,633 | 0.00 | 0.00 | -0.00 | buy |
| WestHill Financial Advisors, Inc. | 228,333 | 228,333 | 0 | 0.55 | 0.41 | -0.14 | hold |
| Cinctive Capital Management LP | 116,133 | 191,015 | +74,882 | 0.07 | 0.09 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 21,900 | 184,800 | +162,900 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 175,000 | 175,000 | 0 | 1.00 | 0.52 | -0.49 | hold |
| TWO SIGMA ADVISERS, LP | 284,600 | 174,700 | -109,900 | 0.01 | 0.00 | -0.00 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 210,000 | 170,000 | -40,000 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 137,271 | 159,921 | +22,650 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 152,060 | 152,060 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 374,850 | 149,141 | -225,709 | 0.02 | 0.00 | -0.01 | sell |
| Swiss National Bank | 131,000 | 133,400 | +2,400 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 193,494 | 130,130 | -63,364 | 0.03 | 0.02 | -0.01 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 121,583 | +121,583 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 125,227 | 114,418 | -10,809 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 42,186 | 104,633 | +62,447 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 232,055 | 98,145 | -133,910 | 0.00 | 0.00 | -0.00 | sell |
| Jasper Ridge Partners, L.P. | 95,711 | 95,711 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Rafferty Asset Management, LLC | 75,723 | 92,445 | +16,722 | 0.00 | 0.00 | -0.00 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.61 | 0.46 | -0.14 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 90,920 | 84,359 | -6,561 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 62,420 | 82,917 | +20,497 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 100,271 | 76,544 | -23,727 | 0.01 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 62,871 | 74,784 | +11,913 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 58,741 | 74,495 | +15,754 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 66,994 | 66,543 | -451 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 63,320 | 63,320 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 158,724 | 62,875 | -95,849 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 61,515 | +61,515 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 52,131 | 60,704 | +8,573 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 2,514 | 60,436 | +57,922 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 58,898 | 58,898 | 0 | 0.11 | 0.08 | -0.03 | hold |
| Y-Intercept (Hong Kong) Ltd | 0 | 55,231 | +55,231 | 0.00 | 0.01 | +0.01 | buy |
| Lighthouse Investment Partners, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 50,482 | 47,533 | -2,949 | 0.00 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 43,544 | 46,609 | +3,065 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 45,218 | 45,218 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEOS Investment Management LLC | 81,112 | 44,732 | -36,380 | 0.01 | 0.00 | -0.01 | sell |
| TEMA ETFS LLC | 81,112 | 44,732 | -36,380 | 0.25 | 0.03 | -0.21 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 43,863 | +43,863 | 0.00 | 0.00 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 26,406 | 42,759 | +16,353 | 0.03 | 0.03 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 42,755 | +42,755 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 45,005 | 40,098 | -4,907 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 93,400 | 39,758 | -53,642 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 37,943 | +37,943 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 35,742 | +35,742 | 0.00 | 0.02 | +0.02 | buy |
| HSBC HOLDINGS PLC | 19,503 | 34,239 | +14,736 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 42,353 | 33,279 | -9,074 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 31,200 | 31,200 | 0 | 0.06 | 0.03 | -0.03 | hold |
| OXFORD ASSET MANAGEMENT LLP | 0 | 29,952 | +29,952 | 0.00 | 0.09 | +0.09 | buy |
| FRANKLIN RESOURCES INC | 70,861 | 29,077 | -41,784 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 76,472 | 28,784 | -47,688 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 0 | 26,818 | +26,818 | 0.00 | 0.00 | +0.00 | buy |