| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 253,413 | 3,135,037 | +2,881,624 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 0 | 717,654 | +717,654 | 0.00 | 0.82 | +0.82 | buy |
| ARK Investment Management LLC | 2,593,047 | 3,194,999 | +601,952 | 0.16 | 0.20 | +0.04 | buy |
| DEUTSCHE BANK AG\ | 19,595 | 504,205 | +484,610 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 250,000 | 690,112 | +440,112 | 0.64 | 1.42 | +0.78 | buy |
| Redmile Group, LLC | 2,848,827 | 3,256,519 | +407,692 | 1.07 | 1.20 | +0.14 | buy |
| NORGES BANK | 0 | 258,400 | +258,400 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 50,148 | 297,769 | +247,621 | 0.01 | 0.04 | +0.03 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 195,136 | +195,136 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 40,826 | 142,146 | +101,320 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 288,157 | 377,588 | +89,431 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 26,800 | 115,200 | +88,400 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 86,269 | +86,269 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 88,066 | 159,318 | +71,252 | 0.02 | 0.04 | +0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 26,757 | 94,772 | +68,015 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 11,978 | 74,842 | +62,864 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 145,053 | 205,324 | +60,271 | 0.00 | 0.00 | +0.00 | buy |
| DENALI ADVISORS LLC | 0 | 57,500 | +57,500 | 0.00 | 0.18 | +0.18 | buy |
| Pennant Investors, LP | 0 | 56,800 | +56,800 | 0.00 | 0.18 | +0.18 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 568,576 | 622,297 | +53,721 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 60,318 | 110,712 | +50,394 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 0 | 43,755 | +43,755 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 958,043 | 1,000,044 | +42,001 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,045,285 | 1,080,523 | +35,238 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 27,456 | +27,456 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 27,400 | +27,400 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 23,687 | +23,687 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 888 | 23,605 | +22,717 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 22,071 | +22,071 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 20,514 | +20,514 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 48,065 | 67,323 | +19,258 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 19,248 | +19,248 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 15,718 | +15,718 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 15,332 | +15,332 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 0 | 14,923 | +14,923 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 57,722 | 72,540 | +14,818 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 26,564 | 39,853 | +13,289 | 0.11 | 0.13 | +0.03 | buy |
| Nebula Research & Development LLC | 0 | 12,894 | +12,894 | 0.00 | 0.04 | +0.04 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 36,138 | 49,018 | +12,880 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 30,839 | 43,290 | +12,451 | 0.00 | 0.00 | +0.00 | buy |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 0 | 12,126 | +12,126 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,377,978 | 2,389,966 | +11,988 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 11,068 | +11,068 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 0 | 10,980 | +10,980 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 19,200 | 29,100 | +9,900 | 0.00 | 0.00 | +0.00 | buy |
| B. Metzler seel. Sohn & Co. AG | 27,038 | 36,171 | +9,133 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,131 | 16,156 | +6,025 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 20,639 | 26,601 | +5,962 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 32,970 | 38,456 | +5,486 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,244 | 5,611 | +4,367 | 0.00 | 0.01 | +0.01 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 11,811 | 15,823 | +4,012 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 47,404 | 50,825 | +3,421 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 247,080 | 250,327 | +3,247 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 320,907 | 323,729 | +2,822 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 170,286 | 173,077 | +2,791 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 9,011 | 10,356 | +1,345 | 0.04 | 0.07 | +0.02 | buy |
| BARCLAYS PLC | 67,467 | 68,739 | +1,272 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 183,923 | 185,070 | +1,147 | 0.01 | 0.01 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 125,839 | 126,001 | +162 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 75,049 | 75,107 | +58 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 30,483 | 30,498 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 357,287 | 357,287 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 4,621 | 4,621 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CORNERCAP INVESTMENT COUNSEL INC | 18,511 | 18,511 | 0 | 0.03 | 0.03 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 46,460 | 46,460 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 3,882,125 | 3,882,125 | 0 | 0.18 | 0.46 | +0.28 | hold |
| BBR PARTNERS, LLC | 20,988 | 20,988 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Blackstone Inc. | 27,119 | 27,119 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jasper Ridge Partners, L.P. | 95,711 | 95,711 | 0 | 0.04 | 0.04 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 79,907 | 79,907 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 152 | 152 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ArrowMark Colorado Holdings LLC | 314,762 | 314,762 | 0 | 0.03 | 0.04 | +0.01 | hold |
| MetLife Investment Management, LLC | 23,288 | 23,288 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bain Capital Life Sciences Investors, LLC | 1,822,883 | 1,822,883 | 0 | 1.60 | 1.80 | +0.20 | hold |
| WestHill Financial Advisors, Inc. | 283,333 | 283,333 | 0 | 0.65 | 0.77 | +0.13 | hold |
| Avalon Trust Co | 7,056 | 7,056 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Deep Track Capital, LP | 2,997,830 | 2,997,830 | 0 | 0.91 | 1.08 | +0.17 | hold |
| Federation des caisses Desjardins du Quebec | 1,200 | 1,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.30 | 0.40 | +0.11 | hold |
| FIDUCIARY TRUST CO | 14,074 | 14,074 | 0 | 0.00 | 0.00 | +0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,703 | 2,703 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 19,244 | 19,244 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 17,611 | 17,611 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FRANKLIN RESOURCES INC | 22,632 | 22,621 | -11 | 0.00 | 0.00 | +0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 115 | 66 | -49 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 23,757 | 23,661 | -96 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 187 | 74 | -113 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 259 | 96 | -163 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 1,235 | 1,018 | -217 | 0.00 | 0.00 | +0.00 | sell |
| SIGNATUREFD, LLC | 906 | 680 | -226 | 0.00 | 0.00 | -0.00 | sell |
| NATIXIS | 5,760 | 5,472 | -288 | 0.00 | 0.00 | +0.00 | sell |
| Mariner, LLC | 31,927 | 31,539 | -388 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 4,504 | 4,046 | -458 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Middle East FZE | 651 | 0 | -651 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 1,108 | 67 | -1,041 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 1,114 | 0 | -1,114 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 1,265 | 25 | -1,240 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 15,531 | 14,135 | -1,396 | 0.00 | 0.00 | +0.00 | sell |
| Aquatic Capital Management LLC | 1,800 | 0 | -1,800 | 0.00 | 0.00 | -0.00 | sell |