| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 586,902 | 10,634,231 | +10,047,329 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 7,181,535 | 7,675,672 | +494,137 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 4,011,814 | 4,345,266 | +333,452 | 0.00 | 0.00 | -0.00 | buy |
| Redmile Group, LLC | 4,280,981 | 4,192,627 | -88,354 | 5.67 | 5.50 | -0.16 | sell |
| BAKER BROS. ADVISORS LP | 3,882,125 | 3,882,125 | 0 | 0.90 | 0.78 | -0.12 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 3,482,105 | 3,586,605 | +104,500 | 0.01 | 0.01 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,068,961 | 3,007,327 | -61,634 | 0.01 | 0.01 | -0.00 | sell |
| Commodore Capital LP | 1,650,000 | 3,000,000 | +1,350,000 | 2.32 | 4.14 | +1.83 | buy |
| Deep Track Capital, LP | 3,868,104 | 3,000,000 | -868,104 | 2.77 | 2.12 | -0.66 | sell |
| STATE STREET CORP | 2,371,271 | 2,803,260 | +431,989 | 0.00 | 0.00 | -0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 2,548,091 | 2,380,428 | -167,663 | 0.03 | 0.03 | -0.01 | sell |
| Soleus Capital Management, L.P. | 1,065,834 | 2,102,833 | +1,036,999 | 1.99 | 3.00 | +1.01 | buy |
| Pictet Asset Management Holding SA | 1,788,530 | 1,768,917 | -19,613 | 0.04 | 0.04 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,448,040 | 1,585,127 | +137,087 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 1,878,564 | 1,564,966 | -313,598 | 0.00 | 0.00 | -0.00 | sell |
| ARK Investment Management LLC | 2,216,365 | 1,530,293 | -686,072 | 0.46 | 0.24 | -0.22 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,333,333 | +1,333,333 | 0.00 | 0.33 | +0.33 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,285,632 | 1,279,691 | -5,941 | 0.25 | 0.20 | -0.05 | sell |
| Affinity Asset Advisors, LLC | 860,399 | 940,083 | +79,684 | 3.00 | 2.77 | -0.23 | buy |
| Point72 Asset Management, L.P. | 0 | 872,959 | +872,959 | 0.00 | 0.05 | +0.05 | buy |
| CITADEL ADVISORS LLC | 1,531,205 | 851,519 | -679,686 | 0.04 | 0.01 | -0.02 | sell |
| Sumitomo Mitsui Trust Group, Inc. | 553,251 | 789,222 | +235,971 | 0.01 | 0.01 | +0.00 | buy |
| Nikko Asset Management Americas, Inc. | 552,602 | 789,222 | +236,620 | 0.14 | 0.16 | +0.02 | buy |
| NORTHERN TRUST CORP | 566,855 | 659,788 | +92,933 | 0.00 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 1,061,959 | 634,626 | -427,333 | 0.14 | 0.07 | -0.07 | sell |
| WASATCH ADVISORS LP | 708,377 | 599,401 | -108,976 | 0.08 | 0.06 | -0.02 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 511,720 | 572,834 | +61,114 | 0.00 | 0.00 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 438,971 | 532,172 | +93,201 | 1.26 | 1.34 | +0.08 | buy |
| DEUTSCHE BANK AG\ | 854,682 | 531,197 | -323,485 | 0.01 | 0.00 | -0.00 | sell |
| SAMLYN CAPITAL, LLC | 568,264 | 515,840 | -52,424 | 0.21 | 0.15 | -0.05 | sell |
| DIMENSIONAL FUND ADVISORS LP | 501,569 | 506,839 | +5,270 | 0.00 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 425,000 | 485,000 | +60,000 | 0.75 | 0.54 | -0.21 | buy |
| GOLDMAN SACHS GROUP INC | 513,221 | 463,469 | -49,752 | 0.00 | 0.00 | -0.00 | sell |
| Patient Square Capital LP | 325,789 | 446,296 | +120,507 | 2.72 | 3.14 | +0.43 | buy |
| LORD, ABBETT & CO. LLC | 350,640 | 437,772 | +87,132 | 0.03 | 0.03 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 221,718 | 424,137 | +202,419 | 0.00 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 355,602 | 402,955 | +47,353 | 0.06 | 0.05 | -0.02 | buy |
| Opaleye Management Inc. | 420,000 | 378,500 | -41,500 | 1.57 | 1.25 | -0.33 | sell |
| Ensign Peak Advisors, Inc | 180,000 | 374,673 | +194,673 | 0.01 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 214,728 | 353,471 | +138,743 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 336,879 | 338,462 | +1,583 | 0.06 | 0.04 | -0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 330,614 | +330,614 | 0.00 | 0.17 | +0.17 | buy |
| NORGES BANK | 318,800 | 318,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ArrowMark Colorado Holdings LLC | 314,762 | 314,762 | 0 | 0.09 | 0.08 | -0.01 | hold |
| BESSEMER GROUP INC | 306,053 | 306,003 | -50 | 0.01 | 0.01 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 300,000 | 290,000 | -10,000 | 0.55 | 0.56 | +0.01 | sell |
| Integral Health Asset Management, LLC | 200,000 | 250,000 | +50,000 | 0.53 | 0.42 | -0.11 | buy |
| PRIMECAP MANAGEMENT CO/CA/ | 290,000 | 232,000 | -58,000 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 229,369 | +229,369 | 0.00 | 0.02 | +0.02 | buy |
| WestHill Financial Advisors, Inc. | 238,333 | 228,333 | -10,000 | 1.20 | 0.96 | -0.24 | sell |
| Bank of New York Mellon Corp | 175,266 | 190,905 | +15,639 | 0.00 | 0.00 | -0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 166,014 | 168,762 | +2,748 | 0.02 | 0.02 | -0.00 | buy |
| Darwin Global Management, Ltd. | 0 | 163,681 | +163,681 | 0.00 | 0.29 | +0.29 | buy |
| Cinctive Capital Management LP | 105,228 | 158,972 | +53,744 | 0.14 | 0.16 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 138,124 | 150,935 | +12,811 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 128,344 | 149,336 | +20,992 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 128,524 | 146,713 | +18,189 | 0.00 | 0.00 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 135,903 | +135,903 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 50,709 | 135,084 | +84,375 | 0.00 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 124,025 | +124,025 | 0.00 | 0.04 | +0.04 | buy |
| FRANKLIN RESOURCES INC | 123,101 | 120,445 | -2,656 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 93,593 | 116,186 | +22,593 | 0.01 | 0.01 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 113,838 | 114,623 | +785 | 0.06 | 0.05 | -0.01 | buy |
| D. E. Shaw & Co., Inc. | 72,840 | 112,841 | +40,001 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 49,593 | 107,350 | +57,757 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 106,900 | 106,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 90,918 | 103,233 | +12,315 | 0.00 | 0.00 | -0.00 | buy |
| Velan Capital Investment Management LP | 0 | 97,889 | +97,889 | 0.00 | 1.59 | +1.59 | buy |
| Jasper Ridge Partners, L.P. | 95,711 | 95,711 | 0 | 0.06 | 0.06 | -0.00 | hold |
| Allspring Global Investments Holdings, LLC | 140,273 | 89,920 | -50,353 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 34,613 | 85,662 | +51,049 | 0.01 | 0.02 | +0.01 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.81 | 0.93 | +0.12 | hold |
| TWO SIGMA ADVISERS, LP | 59,100 | 79,100 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 67,280 | 76,634 | +9,354 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 102,866 | 75,113 | -27,753 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 0 | 74,619 | +74,619 | 0.00 | 0.03 | +0.03 | buy |
| AQR CAPITAL MANAGEMENT LLC | 46,920 | 70,861 | +23,941 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 69,415 | 67,404 | -2,011 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 63,320 | 63,320 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 59,899 | 60,417 | +518 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 21,540 | 60,212 | +38,672 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 20,268 | 55,079 | +34,811 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 52,454 | 52,331 | -123 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 413,340 | 51,980 | -361,360 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 37,096 | 50,126 | +13,030 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 50,098 | +50,098 | 0.00 | 0.17 | +0.17 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,472 | 49,686 | +29,214 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38,619 | 44,518 | +5,899 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 35,239 | 42,539 | +7,300 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 40,803 | 39,279 | -1,524 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 40,434 | 39,234 | -1,200 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 18,901 | 35,836 | +16,935 | 0.00 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 728 | 35,745 | +35,017 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 260,000 | 34,985 | -225,015 | 1.81 | 0.19 | -1.63 | sell |
| Corebridge Financial, Inc. | 34,137 | 34,907 | +770 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 15,231 | 32,152 | +16,921 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 31,795 | 31,716 | -79 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 0 | 31,396 | +31,396 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 30,383 | 31,025 | +642 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 68,148 | 30,895 | -37,253 | 0.00 | 0.00 | -0.00 | sell |