| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 586,902 | 10,634,231 | +10,047,329 | 0.00 | 0.01 | +0.01 | buy |
| Commodore Capital LP | 1,650,000 | 3,000,000 | +1,350,000 | 2.32 | 4.14 | +1.83 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,333,333 | +1,333,333 | 0.00 | 0.33 | +0.33 | buy |
| Soleus Capital Management, L.P. | 1,065,834 | 2,102,833 | +1,036,999 | 1.99 | 3.00 | +1.01 | buy |
| Point72 Asset Management, L.P. | 0 | 872,959 | +872,959 | 0.00 | 0.05 | +0.05 | buy |
| BlackRock, Inc. | 7,181,535 | 7,675,672 | +494,137 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 2,371,271 | 2,803,260 | +431,989 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 4,011,814 | 4,345,266 | +333,452 | 0.00 | 0.00 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 330,614 | +330,614 | 0.00 | 0.17 | +0.17 | buy |
| Nikko Asset Management Americas, Inc. | 552,602 | 789,222 | +236,620 | 0.14 | 0.16 | +0.02 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 553,251 | 789,222 | +235,971 | 0.01 | 0.01 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 229,369 | +229,369 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 221,718 | 424,137 | +202,419 | 0.00 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 180,000 | 374,673 | +194,673 | 0.01 | 0.01 | +0.01 | buy |
| Darwin Global Management, Ltd. | 0 | 163,681 | +163,681 | 0.00 | 0.29 | +0.29 | buy |
| Qube Research & Technologies Ltd | 214,728 | 353,471 | +138,743 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,448,040 | 1,585,127 | +137,087 | 0.00 | 0.00 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 135,903 | +135,903 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 124,025 | +124,025 | 0.00 | 0.04 | +0.04 | buy |
| Patient Square Capital LP | 325,789 | 446,296 | +120,507 | 2.72 | 3.14 | +0.43 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,482,105 | 3,586,605 | +104,500 | 0.01 | 0.01 | -0.00 | buy |
| Velan Capital Investment Management LP | 0 | 97,889 | +97,889 | 0.00 | 1.59 | +1.59 | buy |
| Parkman Healthcare Partners LLC | 438,971 | 532,172 | +93,201 | 1.26 | 1.34 | +0.08 | buy |
| NORTHERN TRUST CORP | 566,855 | 659,788 | +92,933 | 0.00 | 0.00 | -0.00 | buy |
| LORD, ABBETT & CO. LLC | 350,640 | 437,772 | +87,132 | 0.03 | 0.03 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 50,709 | 135,084 | +84,375 | 0.00 | 0.01 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 860,399 | 940,083 | +79,684 | 3.00 | 2.77 | -0.23 | buy |
| Jump Financial, LLC | 0 | 74,619 | +74,619 | 0.00 | 0.03 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 511,720 | 572,834 | +61,114 | 0.00 | 0.00 | -0.00 | buy |
| Vestal Point Capital, LP | 425,000 | 485,000 | +60,000 | 0.75 | 0.54 | -0.21 | buy |
| CITIGROUP INC | 49,593 | 107,350 | +57,757 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 105,228 | 158,972 | +53,744 | 0.14 | 0.16 | +0.03 | buy |
| ExodusPoint Capital Management, LP | 34,613 | 85,662 | +51,049 | 0.01 | 0.02 | +0.01 | buy |
| Polymer Capital Management (HK) LTD | 0 | 50,098 | +50,098 | 0.00 | 0.17 | +0.17 | buy |
| Integral Health Asset Management, LLC | 200,000 | 250,000 | +50,000 | 0.53 | 0.42 | -0.11 | buy |
| Schonfeld Strategic Advisors LLC | 355,602 | 402,955 | +47,353 | 0.06 | 0.05 | -0.02 | buy |
| D. E. Shaw & Co., Inc. | 72,840 | 112,841 | +40,001 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 21,540 | 60,212 | +38,672 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 728 | 35,745 | +35,017 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 20,268 | 55,079 | +34,811 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 31,396 | +31,396 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,472 | 49,686 | +29,214 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 46,920 | 70,861 | +23,941 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 93,593 | 116,186 | +22,593 | 0.01 | 0.01 | +0.00 | buy |
| NEOS Investment Management LLC | 0 | 22,557 | +22,557 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 21,495 | +21,495 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 128,344 | 149,336 | +20,992 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 59,100 | 79,100 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| Proficio Capital Partners LLC | 0 | 19,952 | +19,952 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 128,524 | 146,713 | +18,189 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 18,901 | 35,836 | +16,935 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 15,231 | 32,152 | +16,921 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 175,266 | 190,905 | +15,639 | 0.00 | 0.00 | -0.00 | buy |
| EntryPoint Capital, LLC | 0 | 14,105 | +14,105 | 0.00 | 0.11 | +0.11 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 37,096 | 50,126 | +13,030 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 138,124 | 150,935 | +12,811 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 90,918 | 103,233 | +12,315 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 12,107 | +12,107 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,849 | 14,885 | +12,036 | 0.00 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 11,000 | +11,000 | 0.00 | 0.04 | +0.04 | buy |
| NOMURA HOLDINGS INC | 0 | 10,514 | +10,514 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 67,280 | 76,634 | +9,354 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 8,700 | +8,700 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 35,239 | 42,539 | +7,300 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 15,871 | 23,132 | +7,261 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 22,945 | 30,086 | +7,141 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38,619 | 44,518 | +5,899 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 501,569 | 506,839 | +5,270 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 4,610 | +4,610 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 19,038 | 22,904 | +3,866 | 0.02 | 0.02 | -0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 166,014 | 168,762 | +2,748 | 0.02 | 0.02 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,388 | 15,020 | +2,632 | 0.03 | 0.03 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 13,731 | 16,263 | +2,532 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 336,879 | 338,462 | +1,583 | 0.06 | 0.04 | -0.02 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 15,168 | 16,569 | +1,401 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 0 | 1,028 | +1,028 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 6,468 | 7,345 | +877 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 582 | 1,424 | +842 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 113,838 | 114,623 | +785 | 0.06 | 0.05 | -0.01 | buy |
| Corebridge Financial, Inc. | 34,137 | 34,907 | +770 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 30,383 | 31,025 | +642 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 109 | 733 | +624 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 59,899 | 60,417 | +518 | 0.00 | 0.00 | -0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 238 | +238 | 0.00 | 0.00 | +0.00 | buy |
| EP Wealth Advisors, LLC | 10,693 | 10,815 | +122 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 15,764 | 15,868 | +104 | 0.00 | 0.00 | -0.00 | buy |
| Brooklyn Investment Group | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,330 | 2,361 | +31 | 0.00 | 0.00 | -0.00 | buy |
| Amundi | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Cerity Partners LLC | 10,742 | 10,743 | +1 | 0.00 | 0.00 | -0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 63,320 | 63,320 | 0 | 0.00 | 0.00 | -0.00 | hold |
| LAZARD ASSET MANAGEMENT LLC | 2,155 | 2,155 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 3,882,125 | 3,882,125 | 0 | 0.90 | 0.78 | -0.12 | hold |
| JANUS HENDERSON GROUP PLC | 26,200 | 26,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BBR PARTNERS, LLC | 20,988 | 20,988 | 0 | 0.04 | 0.03 | -0.01 | hold |
| NORGES BANK | 318,800 | 318,800 | 0 | 0.00 | 0.00 | -0.00 | hold |