| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Commodore Capital LP | 1,650,000 | 3,000,000 | +1,350,000 | 2.32 | 4.14 | +1.83 | buy |
| Soleus Capital Management, L.P. | 1,065,834 | 2,102,833 | +1,036,999 | 1.99 | 3.00 | +1.01 | buy |
| Nikko Asset Management Americas, Inc. | 552,602 | 789,222 | +236,620 | 0.14 | 0.16 | +0.02 | buy |
| Patient Square Capital LP | 325,789 | 446,296 | +120,507 | 2.72 | 3.14 | +0.43 | buy |
| Parkman Healthcare Partners LLC | 438,971 | 532,172 | +93,201 | 1.26 | 1.34 | +0.08 | buy |
| LORD, ABBETT & CO. LLC | 350,640 | 437,772 | +87,132 | 0.03 | 0.03 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 860,399 | 940,083 | +79,684 | 2.64 | 2.37 | -0.26 | buy |
| Vestal Point Capital, LP | 425,000 | 485,000 | +60,000 | 0.75 | 0.54 | -0.21 | buy |
| Cinctive Capital Management LP | 105,228 | 158,972 | +53,744 | 0.14 | 0.16 | +0.03 | buy |
| Integral Health Asset Management, LLC | 200,000 | 250,000 | +50,000 | 0.51 | 0.40 | -0.10 | buy |
| Rafferty Asset Management, LLC | 93,593 | 116,186 | +22,593 | 0.01 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 19,038 | 22,904 | +3,866 | 0.02 | 0.02 | 0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 166,014 | 168,762 | +2,748 | 0.02 | 0.02 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,388 | 15,020 | +2,632 | 0.03 | 0.03 | -0.00 | buy |
| Woodline Partners LP | 336,879 | 338,462 | +1,583 | 0.06 | 0.04 | -0.02 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 113,838 | 114,623 | +785 | 0.06 | 0.05 | -0.01 | buy |
| NATIXIS | 3,221 | 2,706 | +515 | 0.00 | 0.00 | 0.00 | sell |
| BESSEMER GROUP INC | 306,053 | 306,003 | -50 | 0.01 | 0.01 | -0.00 | sell |
| Avalon Trust Co | 4,150 | 2,650 | -1,500 | 0.01 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 69,415 | 67,404 | -2,011 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 5,512 | 3,458 | -2,054 | 0.06 | 0.03 | -0.03 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,285,632 | 1,279,691 | -5,941 | 0.25 | 0.20 | -0.05 | sell |
| WestHill Financial Advisors, Inc. | 238,333 | 228,333 | -10,000 | 1.20 | 0.96 | -0.24 | sell |
| Rhenman & Partners Asset Management AB | 300,000 | 290,000 | -10,000 | 0.55 | 0.56 | +0.01 | sell |
| TWINBEECH CAPITAL LP | 65,459 | 29,776 | -35,683 | 0.03 | 0.01 | -0.02 | sell |
| Opaleye Management Inc. | 420,000 | 378,500 | -41,500 | 1.57 | 1.25 | -0.33 | sell |
| SAMLYN CAPITAL, LLC | 568,264 | 515,840 | -52,424 | 0.19 | 0.15 | -0.05 | sell |
| PRIMECAP MANAGEMENT CO/CA/ | 290,000 | 232,000 | -58,000 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,068,961 | 3,007,327 | -61,634 | 0.01 | 0.01 | -0.00 | sell |
| Redmile Group, LLC | 4,280,981 | 4,192,627 | -88,354 | 5.67 | 5.50 | -0.16 | sell |
| WASATCH ADVISORS LP | 708,377 | 599,401 | -108,976 | 0.08 | 0.06 | -0.02 | sell |
| T. Rowe Price Investment Management, Inc. | 2,548,091 | 2,380,428 | -167,663 | 0.03 | 0.03 | -0.01 | sell |
| Ikarian Capital, LLC | 260,000 | 34,985 | -225,015 | 0.81 | 0.09 | -0.72 | sell |
| Candriam S.C.A. | 1,164,246 | 634,626 | -529,620 | 0.15 | 0.07 | -0.08 | sell |
| ARK Investment Management LLC | 2,216,365 | 1,530,293 | -686,072 | 0.46 | 0.24 | -0.22 | sell |
| Deep Track Capital, LP | 3,868,104 | 3,000,000 | -868,104 | 2.77 | 2.12 | -0.66 | sell |