| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 3,678,394 | 8,093,908 | +4,415,514 | 3.31 | 11.31 | +8.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,416,149 | 3,555,877 | +2,139,728 | 0.38 | 1.20 | +0.82 | buy |
| Vestal Point Capital, LP | 3,475,000 | 4,690,000 | +1,215,000 | 1.46 | 3.26 | +1.81 | buy |
| Deep Track Capital, LP | 6,057,024 | 7,036,455 | +979,431 | 1.56 | 3.04 | +1.48 | buy |
| BAKER BROS. ADVISORS LP | 3,882,125 | 4,658,556 | +776,431 | 0.26 | 0.52 | +0.26 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 43,863 | 735,174 | +691,311 | 0.00 | 0.05 | +0.05 | buy |
| Candriam S.C.A. | 262,384 | 534,259 | +271,875 | 0.01 | 0.05 | +0.04 | buy |
| Rhenman & Partners Asset Management AB | 347,500 | 537,500 | +190,000 | 0.36 | 0.95 | +0.60 | buy |
| ARK Investment Management LLC | 1,510,404 | 1,602,539 | +92,135 | 0.08 | 0.20 | +0.12 | buy |
| Susquehanna Portfolio Strategies, LLC | 15,002 | 86,423 | +71,421 | 0.00 | 0.03 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 31,200 | 72,070 | +40,870 | 0.03 | 0.10 | +0.07 | buy |
| NEOS Investment Management LLC | 44,732 | 77,775 | +33,043 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 44,732 | 76,625 | +31,893 | 0.03 | 0.11 | +0.08 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 42,759 | 65,545 | +22,786 | 0.03 | 0.09 | +0.06 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 246,743 | 261,204 | +14,461 | 0.05 | 0.10 | +0.05 | buy |
| PROFUND ADVISORS LLC | 20,455 | 34,580 | +14,125 | 0.01 | 0.02 | 0.00 | buy |
| Virtus Investment Advisers, LLC | 9,514 | 13,949 | +4,435 | 0.03 | 0.07 | +0.05 | buy |
| China Universal Asset Management Co., Ltd. | 13,400 | 16,518 | +3,118 | 0.01 | 0.02 | +0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,645 | 1,992 | +347 | 0.00 | 0.00 | +0.00 | buy |
| Accent Capital Management, LLC | 70 | 380 | +310 | 0.00 | 0.00 | +0.00 | buy |
| 49 WEALTH MANAGEMENT, LLC | 11,678 | 10,158 | -1,520 | 0.01 | 0.02 | +0.01 | sell |
| Rafferty Asset Management, LLC | 92,445 | 90,515 | -1,930 | 0.00 | 0.01 | +0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 46,609 | 43,743 | -2,866 | 0.00 | 0.00 | +0.00 | sell |
| Integral Health Asset Management, LLC | 350,000 | 300,000 | -50,000 | 0.24 | 0.29 | +0.05 | sell |
| Boxer Capital Management, LLC | 175,000 | 100,000 | -75,000 | 0.52 | 0.42 | -0.10 | sell |
| Cinctive Capital Management LP | 191,015 | 47,707 | -143,308 | 0.09 | 0.05 | -0.04 | sell |
| Kynam Capital Management, LP | 2,168,605 | 1,970,357 | -198,248 | 1.49 | 2.43 | +0.94 | sell |
| Nikko Asset Management Americas, Inc. | 1,557,479 | 1,290,554 | -266,925 | 0.14 | 0.28 | +0.14 | sell |
| T. Rowe Price Investment Management, Inc. | 1,197,415 | 172,838 | -1,024,577 | 0.01 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 2,422,833 | 1,219,394 | -1,203,439 | 1.20 | 0.98 | -0.22 | sell |
| Commodore Capital LP | 3,780,055 | 2,275,000 | -1,505,055 | 1.71 | 2.87 | +1.17 | sell |