| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 6,762,586 | 8,875,194 | +2,112,608 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 3,678,394 | 8,093,908 | +4,415,514 | 3.31 | 11.31 | +8.00 | buy |
| Deep Track Capital, LP | 6,057,024 | 7,036,455 | +979,431 | 1.56 | 3.04 | +1.48 | buy |
| VANGUARD GROUP INC | 4,488,776 | 5,949,512 | +1,460,736 | 0.00 | 0.00 | +0.00 | buy |
| GENERAL ATLANTIC, L.P. | 0 | 4,897,159 | +4,897,159 | 0.00 | 3.23 | +3.23 | buy |
| MORGAN STANLEY | 2,260,746 | 4,881,069 | +2,620,323 | 0.00 | 0.01 | +0.00 | buy |
| Vestal Point Capital, LP | 3,475,000 | 4,690,000 | +1,215,000 | 1.46 | 3.26 | +1.81 | buy |
| BAKER BROS. ADVISORS LP | 3,882,125 | 4,658,556 | +776,431 | 0.26 | 0.52 | +0.26 | buy |
| FMR LLC | 8,887,537 | 4,234,158 | -4,653,379 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 2,862,387 | 3,559,501 | +697,114 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,416,149 | 3,555,877 | +2,139,728 | 0.38 | 1.24 | +0.86 | buy |
| Pictet Asset Management Holding SA | 1,980,540 | 3,467,600 | +1,487,060 | 0.02 | 0.06 | +0.05 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,099,093 | 3,248,361 | +2,149,268 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 2,871,497 | 3,211,680 | +340,183 | 0.06 | 0.10 | +0.04 | buy |
| DEUTSCHE BANK AG\ | 1,438,859 | 2,486,792 | +1,047,933 | 0.00 | 0.02 | +0.01 | buy |
| Rubric Capital Management LP | 0 | 2,473,885 | +2,473,885 | 0.00 | 0.56 | +0.56 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,882,682 | 2,384,998 | +502,316 | 0.00 | 0.00 | +0.00 | buy |
| Commodore Capital LP | 3,780,055 | 2,275,000 | -1,505,055 | 1.71 | 2.87 | +1.17 | sell |
| BRAIDWELL LP | 0 | 2,183,864 | +2,183,864 | 0.00 | 1.32 | +1.32 | buy |
| Kynam Capital Management, LP | 2,168,605 | 1,970,357 | -198,248 | 1.49 | 2.43 | +0.94 | sell |
| ARK Investment Management LLC | 1,510,404 | 1,602,539 | +92,135 | 0.08 | 0.20 | +0.12 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 1,297,893 | +1,297,893 | 0.00 | 0.38 | +0.38 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 1,557,479 | 1,290,554 | -266,925 | 0.01 | 0.01 | +0.01 | sell |
| Nikko Asset Management Americas, Inc. | 1,557,479 | 1,290,554 | -266,925 | 0.14 | 0.28 | +0.14 | sell |
| Soleus Capital Management, L.P. | 2,422,833 | 1,219,394 | -1,203,439 | 1.20 | 0.98 | -0.22 | sell |
| CITADEL ADVISORS LLC | 565,305 | 1,152,930 | +587,625 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 622,299 | 1,077,573 | +455,274 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 967,620 | 967,620 | 0 | 0.83 | 1.32 | +0.49 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 864,380 | 965,892 | +101,512 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 927,729 | +927,729 | 0.00 | 2.09 | +2.09 | buy |
| Woodline Partners LP | 76,544 | 925,444 | +848,900 | 0.00 | 0.07 | +0.06 | buy |
| NORTHERN TRUST CORP | 680,009 | 805,682 | +125,673 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 152,060 | 784,409 | +632,349 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 481,054 | 736,558 | +255,504 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 43,863 | 735,174 | +691,311 | 0.00 | 0.05 | +0.05 | buy |
| Handelsbanken Fonder AB | 520,000 | 547,000 | +27,000 | 0.02 | 0.03 | +0.02 | buy |
| Rhenman & Partners Asset Management AB | 347,500 | 537,500 | +190,000 | 0.36 | 0.95 | +0.60 | buy |
| Candriam S.C.A. | 262,384 | 534,259 | +271,875 | 0.01 | 0.05 | +0.04 | buy |
| Logos Global Management LP | 0 | 500,000 | +500,000 | 0.00 | 0.63 | +0.63 | buy |
| DIMENSIONAL FUND ADVISORS LP | 430,962 | 430,986 | +24 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 362,546 | 423,425 | +60,879 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 159,921 | 343,830 | +183,909 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 314,762 | 314,762 | 0 | 0.05 | 0.13 | +0.08 | hold |
| BESSEMER GROUP INC | 306,003 | 306,003 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Integral Health Asset Management, LLC | 350,000 | 300,000 | -50,000 | 0.24 | 0.29 | +0.05 | sell |
| Bank of New York Mellon Corp | 228,758 | 288,143 | +59,385 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 255,790 | 275,178 | +19,388 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 246,743 | 261,204 | +14,461 | 0.05 | 0.10 | +0.05 | buy |
| BARCLAYS PLC | 245,095 | 256,684 | +11,589 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 237,200 | +237,200 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 230,828 | 230,828 | 0 | 0.00 | 0.01 | +0.00 | hold |
| WestHill Financial Advisors, Inc. | 228,333 | 228,333 | 0 | 0.41 | 0.82 | +0.41 | hold |
| MILLENNIUM MANAGEMENT LLC | 1,523,959 | 179,759 | -1,344,200 | 0.01 | 0.00 | -0.01 | sell |
| T. Rowe Price Investment Management, Inc. | 1,197,415 | 172,838 | -1,024,577 | 0.01 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,352 | 172,364 | +147,012 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 7,367 | 171,102 | +163,735 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 98,145 | 168,843 | +70,698 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 149,141 | 154,459 | +5,318 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 133,400 | 150,000 | +16,600 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 74,495 | 132,094 | +57,599 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 104,633 | 124,749 | +20,116 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 124,000 | +124,000 | 0.00 | 0.49 | +0.49 | buy |
| ALGERT GLOBAL LLC | 563,837 | 119,657 | -444,180 | 0.09 | 0.04 | -0.05 | sell |
| JANE STREET GROUP, LLC | 258,651 | 119,404 | -139,247 | 0.00 | 0.00 | -0.00 | sell |
| Burkehill Global Management, LP | 0 | 118,972 | +118,972 | 0.00 | 0.15 | +0.15 | buy |
| RHUMBLINE ADVISERS | 114,418 | 118,598 | +4,180 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 121,583 | 118,481 | -3,102 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 60,704 | 117,854 | +57,150 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 110,000 | +110,000 | 0.00 | 0.01 | +0.01 | buy |
| Boxer Capital Management, LLC | 175,000 | 100,000 | -75,000 | 0.52 | 0.42 | -0.10 | sell |
| ALLIANCEBERNSTEIN L.P. | 63,320 | 98,190 | +34,870 | 0.00 | 0.00 | +0.00 | buy |
| Jasper Ridge Partners, L.P. | 95,711 | 95,711 | 0 | 0.02 | 0.04 | +0.02 | hold |
| Rafferty Asset Management, LLC | 92,445 | 90,515 | -1,930 | 0.00 | 0.01 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 15,002 | 86,423 | +71,421 | 0.00 | 0.03 | +0.02 | buy |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | 85,000 | 0 | 0.46 | 0.79 | +0.32 | hold |
| Legal & General Group Plc | 82,917 | 84,989 | +2,072 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 80,037 | +80,037 | 0.00 | 0.02 | +0.02 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 0 | 80,000 | +80,000 | 0.00 | 0.02 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,098 | 79,325 | +39,227 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 44,732 | 77,775 | +33,043 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 14,900 | 77,359 | +62,459 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 44,732 | 76,625 | +31,893 | 0.03 | 0.11 | +0.08 | buy |
| Walleye Capital LLC | 0 | 74,869 | +74,869 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 31,200 | 72,070 | +40,870 | 0.03 | 0.10 | +0.07 | buy |
| Verition Fund Management LLC | 0 | 68,754 | +68,754 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 66,543 | 68,019 | +1,476 | 0.00 | 0.00 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 42,759 | 65,545 | +22,786 | 0.03 | 0.09 | +0.06 | buy |
| Russell Investments Group, Ltd. | 60,436 | 63,482 | +3,046 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 58,898 | 58,898 | 0 | 0.08 | 0.17 | +0.10 | hold |
| MetLife Investment Management, LLC | 45,218 | 55,345 | +10,127 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 84,359 | 50,553 | -33,806 | 0.00 | 0.00 | +0.00 | sell |
| Cinctive Capital Management LP | 191,015 | 47,707 | -143,308 | 0.09 | 0.05 | -0.04 | sell |
| JPMORGAN CHASE & CO | 47,533 | 47,288 | -245 | 0.00 | 0.00 | +0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 46,609 | 43,743 | -2,866 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 26,118 | 42,878 | +16,760 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 26,200 | 39,400 | +13,200 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 14,122 | 36,959 | +22,837 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 36,820 | +36,820 | 0.00 | 0.02 | +0.02 | buy |
| SEI INVESTMENTS CO | 0 | 35,976 | +35,976 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 37,943 | 34,760 | -3,183 | 0.00 | 0.00 | +0.00 | sell |