| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GENERAL ATLANTIC, L.P. | 0 | 4,897,159 | +4,897,159 | 0.00 | 3.23 | +3.23 | buy |
| Redmile Group, LLC | 3,678,394 | 8,093,908 | +4,415,514 | 3.31 | 11.31 | +8.00 | buy |
| MORGAN STANLEY | 2,260,746 | 4,881,069 | +2,620,323 | 0.00 | 0.01 | +0.00 | buy |
| Rubric Capital Management LP | 0 | 2,473,885 | +2,473,885 | 0.00 | 0.56 | +0.56 | buy |
| BRAIDWELL LP | 0 | 2,183,864 | +2,183,864 | 0.00 | 1.32 | +1.32 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,099,093 | 3,248,361 | +2,149,268 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 1,416,149 | 3,555,877 | +2,139,728 | 0.38 | 1.24 | +0.86 | buy |
| BlackRock, Inc. | 6,762,586 | 8,875,194 | +2,112,608 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,980,540 | 3,467,600 | +1,487,060 | 0.02 | 0.06 | +0.05 | buy |
| VANGUARD GROUP INC | 4,488,776 | 5,949,512 | +1,460,736 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 1,297,893 | +1,297,893 | 0.00 | 0.38 | +0.38 | buy |
| Vestal Point Capital, LP | 3,475,000 | 4,690,000 | +1,215,000 | 1.46 | 3.26 | +1.81 | buy |
| DEUTSCHE BANK AG\ | 1,438,859 | 2,486,792 | +1,047,933 | 0.00 | 0.02 | +0.01 | buy |
| Deep Track Capital, LP | 6,057,024 | 7,036,455 | +979,431 | 1.56 | 3.04 | +1.48 | buy |
| Longaeva Partners L.P. | 0 | 927,729 | +927,729 | 0.00 | 2.09 | +2.09 | buy |
| Woodline Partners LP | 76,544 | 925,444 | +848,900 | 0.00 | 0.07 | +0.06 | buy |
| BAKER BROS. ADVISORS LP | 3,882,125 | 4,658,556 | +776,431 | 0.26 | 0.52 | +0.26 | buy |
| STATE STREET CORP | 2,862,387 | 3,559,501 | +697,114 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 43,863 | 735,174 | +691,311 | 0.00 | 0.05 | +0.05 | buy |
| Nuveen, LLC | 152,060 | 784,409 | +632,349 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 565,305 | 1,152,930 | +587,625 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,882,682 | 2,384,998 | +502,316 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 500,000 | +500,000 | 0.00 | 0.63 | +0.63 | buy |
| GOLDMAN SACHS GROUP INC | 622,299 | 1,077,573 | +455,274 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 2,871,497 | 3,211,680 | +340,183 | 0.06 | 0.10 | +0.04 | buy |
| Candriam S.C.A. | 262,384 | 534,259 | +271,875 | 0.01 | 0.05 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 481,054 | 736,558 | +255,504 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 237,200 | +237,200 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 347,500 | 537,500 | +190,000 | 0.36 | 0.95 | +0.60 | buy |
| Invesco Ltd. | 159,921 | 343,830 | +183,909 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 7,367 | 171,102 | +163,735 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,352 | 172,364 | +147,012 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 680,009 | 805,682 | +125,673 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 124,000 | +124,000 | 0.00 | 0.49 | +0.49 | buy |
| Burkehill Global Management, LP | 0 | 118,972 | +118,972 | 0.00 | 0.15 | +0.15 | buy |
| Hudson Bay Capital Management LP | 0 | 110,000 | +110,000 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 864,380 | 965,892 | +101,512 | 0.00 | 0.00 | +0.00 | buy |
| ARK Investment Management LLC | 1,510,404 | 1,602,539 | +92,135 | 0.08 | 0.20 | +0.12 | buy |
| Jump Financial, LLC | 0 | 80,037 | +80,037 | 0.00 | 0.02 | +0.02 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 0 | 80,000 | +80,000 | 0.00 | 0.02 | +0.02 | buy |
| Walleye Capital LLC | 0 | 74,869 | +74,869 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 15,002 | 86,423 | +71,421 | 0.00 | 0.03 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 98,145 | 168,843 | +70,698 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 68,754 | +68,754 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 14,900 | 77,359 | +62,459 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 362,546 | 423,425 | +60,879 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 228,758 | 288,143 | +59,385 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 74,495 | 132,094 | +57,599 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 60,704 | 117,854 | +57,150 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 31,200 | 72,070 | +40,870 | 0.03 | 0.10 | +0.07 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,098 | 79,325 | +39,227 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 36,820 | +36,820 | 0.00 | 0.02 | +0.02 | buy |
| SEI INVESTMENTS CO | 0 | 35,976 | +35,976 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 63,320 | 98,190 | +34,870 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 44,732 | 77,775 | +33,043 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 44,732 | 76,625 | +31,893 | 0.03 | 0.11 | +0.08 | buy |
| Maven Securities LTD | 0 | 30,000 | +30,000 | 0.00 | 0.07 | +0.07 | buy |
| Mariner, LLC | 0 | 28,004 | +28,004 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 27,150 | +27,150 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 520,000 | 547,000 | +27,000 | 0.02 | 0.03 | +0.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 14,122 | 36,959 | +22,837 | 0.00 | 0.00 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 42,759 | 65,545 | +22,786 | 0.03 | 0.09 | +0.06 | buy |
| AMERIPRISE FINANCIAL INC | 104,633 | 124,749 | +20,116 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 255,790 | 275,178 | +19,388 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 26,118 | 42,878 | +16,760 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 133,400 | 150,000 | +16,600 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 246,743 | 261,204 | +14,461 | 0.05 | 0.10 | +0.05 | buy |
| PROFUND ADVISORS LLC | 20,455 | 34,580 | +14,125 | 0.01 | 0.02 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 26,200 | 39,400 | +13,200 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,829 | 31,191 | +12,362 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 245,095 | 256,684 | +11,589 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 9,030 | 20,520 | +11,490 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 10,842 | +10,842 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 21,195 | 31,595 | +10,400 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 10,172 | +10,172 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 45,218 | 55,345 | +10,127 | 0.00 | 0.01 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 14,445 | 23,885 | +9,440 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 21,962 | 30,955 | +8,993 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 12,636 | 20,137 | +7,501 | 0.01 | 0.02 | +0.01 | buy |
| ProShare Advisors LLC | 15,614 | 22,794 | +7,180 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 11,034 | 18,104 | +7,070 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 20,910 | 26,729 | +5,819 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 149,141 | 154,459 | +5,318 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 9,514 | 13,949 | +4,435 | 0.03 | 0.07 | +0.05 | buy |
| RHUMBLINE ADVISERS | 114,418 | 118,598 | +4,180 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 3,300 | +3,300 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 3,175 | +3,175 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,400 | 16,518 | +3,118 | 0.01 | 0.02 | +0.01 | buy |
| Russell Investments Group, Ltd. | 60,436 | 63,482 | +3,046 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 2,820 | +2,820 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 82,917 | 84,989 | +2,072 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,956 | 4,926 | +1,970 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 6,298 | 8,136 | +1,838 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 20,316 | 21,990 | +1,674 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 66,543 | 68,019 | +1,476 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 351 | 1,541 | +1,190 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 1,068 | +1,068 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 15,400 | 16,200 | +800 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 69 | 828 | +759 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 5,202 | 5,777 | +575 | 0.00 | 0.00 | +0.00 | buy |