| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 7,270,000 | 11,063,862 | +3,793,862 | 0.02 | 0.04 | +0.02 | buy |
| VR Adviser, LLC | 0 | 4,843,380 | +4,843,380 | 0.00 | 1.26 | +1.26 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,270,000 | 4,763,158 | +493,158 | 0.03 | 0.05 | +0.02 | buy |
| ORBIMED ADVISORS LLC | 2,610,600 | 4,715,864 | +2,105,264 | 0.26 | 0.72 | +0.46 | buy |
| MARSHALL WACE, LLP | 3,189,662 | 4,481,606 | +1,291,944 | 0.01 | 0.03 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,673,017 | 3,907,265 | +2,234,248 | 0.01 | 0.02 | +0.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 2,947,369 | +2,947,369 | 0.00 | 0.22 | +0.22 | buy |
| Ikarian Capital, LLC | 3,068,359 | 2,688,359 | -380,000 | 1.92 | 2.68 | +0.76 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,880,006 | 2,132,053 | +252,047 | 0.06 | 0.11 | +0.05 | buy |
| AMERIPRISE FINANCIAL INC | 1,920,099 | 1,590,946 | -329,153 | 0.00 | 0.00 | +0.00 | sell |
| Polar Capital Holdings Plc | 0 | 1,414,621 | +1,414,621 | 0.00 | 0.04 | +0.04 | buy |
| BlackRock, Inc. | 1,267,503 | 1,289,550 | +22,047 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 385,942 | 1,011,572 | +625,630 | 0.00 | 0.01 | +0.01 | buy |
| Sio Capital Management, LLC | 0 | 965,000 | +965,000 | 0.00 | 0.97 | +0.97 | buy |
| Opaleye Management Inc. | 935,000 | 935,000 | 0 | 0.60 | 0.86 | +0.26 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 854,932 | 848,683 | -6,249 | 0.00 | 0.00 | +0.00 | sell |
| GREAT POINT PARTNERS LLC | 0 | 842,106 | +842,106 | 0.00 | 1.44 | +1.44 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 842,106 | +842,106 | 0.00 | 0.10 | +0.10 | buy |
| Soleus Capital Management, L.P. | 0 | 842,106 | +842,106 | 0.00 | 0.24 | +0.24 | buy |
| Boxer Capital Management, LLC | 0 | 842,106 | +842,106 | 0.00 | 0.77 | +0.77 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 835,300 | 729,055 | -106,245 | 0.10 | 0.12 | +0.01 | sell |
| Corient Private Wealth LLC | 719,582 | 719,582 | 0 | 0.00 | 0.01 | +0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 526,718 | 712,540 | +185,822 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 145,000 | 699,039 | +554,039 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 155,529 | 653,333 | +497,804 | 0.00 | 0.01 | +0.01 | buy |
| Commodore Capital LP | 0 | 633,901 | +633,901 | 0.00 | 0.26 | +0.26 | buy |
| STEMPOINT CAPITAL LP | 0 | 597,409 | +597,409 | 0.00 | 0.80 | +0.80 | buy |
| Point72 Asset Management, L.P. | 187,377 | 504,820 | +317,443 | 0.00 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 30,866 | 451,918 | +421,052 | 0.01 | 0.19 | +0.18 | buy |
| Integral Health Asset Management, LLC | 0 | 450,000 | +450,000 | 0.00 | 0.17 | +0.17 | buy |
| Knott David M Jr | 0 | 439,300 | +439,300 | 0.00 | 1.82 | +1.82 | buy |
| Woodline Partners LP | 0 | 421,052 | +421,052 | 0.00 | 0.01 | +0.01 | buy |
| Birchview Capital, LP | 0 | 409,387 | +409,387 | 0.00 | 1.62 | +1.62 | buy |
| TWO SIGMA INVESTMENTS, LP | 572,835 | 408,095 | -164,740 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 320,820 | 357,040 | +36,220 | 0.00 | 0.00 | +0.00 | buy |
| PARSONS CAPITAL MANAGEMENT INC/RI | 263,000 | 352,500 | +89,500 | 0.07 | 0.11 | +0.04 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 315,788 | +315,788 | 0.00 | 0.15 | +0.15 | buy |
| AdvisorShares Investments LLC | 319,510 | 295,872 | -23,638 | 0.26 | 0.38 | +0.12 | sell |
| Eversept Partners, LP | 0 | 277,899 | +277,899 | 0.00 | 0.13 | +0.13 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 547,854 | 252,457 | -295,397 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 224,846 | 224,846 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANE STREET GROUP, LLC | 271,109 | 221,969 | -49,140 | 0.00 | 0.00 | +0.00 | sell |
| Ally Bridge Group (NY) LLC | 0 | 210,525 | +210,525 | 0.00 | 1.46 | +1.46 | buy |
| DIADEMA PARTNERS LP | 389,395 | 200,842 | -188,553 | 1.12 | 0.58 | -0.54 | sell |
| MORGAN STANLEY | 0 | 198,463 | +198,463 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 185,000 | 167,200 | -17,800 | 0.00 | 0.00 | +0.00 | sell |
| SEI INVESTMENTS CO | 98,965 | 166,614 | +67,649 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 165,453 | 157,734 | -7,719 | 0.00 | 0.00 | +0.00 | sell |
| Informed Momentum Co LLC | 162,552 | 130,935 | -31,617 | 0.09 | 0.11 | +0.02 | sell |
| UBS Group AG | 0 | 126,672 | +126,672 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 125,941 | +125,941 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 140,000 | 120,000 | -20,000 | 0.03 | 0.04 | +0.01 | sell |
| Burkehill Global Management, LP | 0 | 105,263 | +105,263 | 0.00 | 0.03 | +0.03 | buy |
| MGO ONE SEVEN LLC | 100,000 | 100,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BARCLAYS PLC | 60,000 | 88,953 | +28,953 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 73,595 | +73,595 | 0.00 | 0.01 | +0.01 | buy |
| MANGROVE PARTNERS IM, LLC | 27,380 | 71,705 | +44,325 | 0.01 | 0.04 | +0.03 | buy |
| LMR Partners LLP | 55,600 | 63,584 | +7,984 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 138,233 | 63,426 | -74,807 | 0.00 | 0.00 | -0.00 | sell |
| Hillsdale Investment Management Inc. | 0 | 53,600 | +53,600 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 53,081 | 53,081 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Persistent Asset Partners Ltd | 231,123 | 50,773 | -180,350 | 0.54 | 0.14 | -0.40 | sell |
| apricus wealth, LLC | 47,462 | 47,462 | 0 | 0.12 | 0.16 | +0.04 | hold |
| FIFTH LANE CAPITAL, LP | 0 | 45,000 | +45,000 | 0.00 | 0.38 | +0.38 | buy |
| Hudson Bay Capital Management LP | 26,247 | 42,141 | +15,894 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 65,900 | 41,600 | -24,300 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 0 | 34,057 | +34,057 | 0.00 | 0.04 | +0.04 | buy |
| XTX Topco Ltd | 41,293 | 33,606 | -7,687 | 0.01 | 0.00 | -0.00 | sell |
| AlTi Global, Inc. | 31,975 | 31,975 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pale Fire Capital SE | 44,550 | 31,650 | -12,900 | 0.03 | 0.02 | -0.01 | sell |
| BANK OF NOVA SCOTIA | 0 | 30,600 | +30,600 | 0.00 | 0.00 | +0.00 | buy |
| Robertson Stephens Wealth Management, LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Diametric Capital, LP | 0 | 24,006 | +24,006 | 0.00 | 0.04 | +0.04 | buy |
| Schonfeld Strategic Advisors LLC | 13,216 | 23,247 | +10,031 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 22,442 | +22,442 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 19,566 | +19,566 | 0.00 | 0.01 | +0.01 | buy |
| Jefferies Financial Group Inc. | 21,655 | 16,120 | -5,535 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 22,534 | 15,414 | -7,120 | 0.00 | 0.00 | -0.00 | sell |
| Scientech Research LLC | 0 | 14,609 | +14,609 | 0.00 | 0.08 | +0.08 | buy |
| GROUP ONE TRADING LLC | 0 | 14,350 | +14,350 | 0.00 | 0.00 | +0.00 | buy |
| Lido Advisors, LLC | 13,905 | 13,905 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Graham Capital Management, L.P. | 25,608 | 13,493 | -12,115 | 0.00 | 0.00 | -0.00 | sell |
| Keebeck Wealth Management | 0 | 13,000 | +13,000 | 0.00 | 0.01 | +0.01 | buy |
| State of Wyoming | 0 | 12,581 | +12,581 | 0.00 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 53,444 | 12,498 | -40,946 | 0.00 | 0.00 | -0.00 | sell |
| World Investment Advisors | 10,444 | 10,444 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bedel Financial Consulting, Inc. | 10,000 | 10,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 3,040 | 8,320 | +5,280 | 0.00 | 0.00 | +0.00 | buy |
| ANTIPODES PARTNERS Ltd | 0 | 3,035 | +3,035 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 2,000 | 2,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| American Capital Advisory, LLC | 1,954 | 1,954 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Farther Finance Advisors, LLC | 684 | 684 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 57 | 41 | -16 | 0.00 | 0.00 | +0.00 | sell |
| Caitong International Asset Management Co., Ltd | 0 | 36 | +36 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 162,200 | 0 | -162,200 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 18,611 | 0 | -18,611 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 17,640 | 0 | -17,640 | 0.00 | 0.00 | -0.00 | sell |
| Tortoise Investment Management, LLC | 13,909 | 0 | -13,909 | 0.01 | 0.00 | -0.01 | sell |
| Lighthouse Investment Partners, LLC | 15,960 | 0 | -15,960 | 0.00 | 0.00 | -0.00 | sell |
| Front Row Advisors LLC | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |