| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 1,289,550 | 7,426,780 | +6,137,230 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 4,843,380 | 6,844,305 | +2,000,925 | 1.26 | 1.44 | +0.18 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,763,158 | 4,763,158 | 0 | 0.05 | 0.05 | -0.00 | hold |
| ORBIMED ADVISORS LLC | 4,715,864 | 3,631,195 | -1,084,669 | 0.72 | 0.48 | -0.24 | sell |
| STATE STREET CORP | 357,040 | 2,517,550 | +2,160,510 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 848,683 | 2,492,573 | +1,643,890 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,907,265 | 2,361,827 | -1,545,438 | 0.02 | 0.01 | -0.01 | sell |
| MARSHALL WACE, LLP | 4,481,606 | 2,246,839 | -2,234,767 | 0.03 | 0.01 | -0.02 | sell |
| Ikarian Capital, LLC | 2,688,359 | 2,148,359 | -540,000 | 2.68 | 2.43 | -0.24 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,132,053 | 2,132,053 | 0 | 0.11 | 0.09 | -0.02 | hold |
| AMERIPRISE FINANCIAL INC | 1,590,946 | 1,937,972 | +347,026 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 842,106 | 1,858,416 | +1,016,310 | 0.10 | 0.17 | +0.07 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 252,457 | 1,520,688 | +1,268,231 | 0.00 | 0.02 | +0.02 | buy |
| STEMPOINT CAPITAL LP | 597,409 | 1,460,093 | +862,684 | 0.80 | 1.75 | +0.95 | buy |
| Commodore Capital LP | 633,901 | 1,425,000 | +791,099 | 0.26 | 0.59 | +0.33 | buy |
| Polar Capital Holdings Plc | 1,414,621 | 1,340,428 | -74,193 | 0.04 | 0.03 | -0.02 | sell |
| CITADEL ADVISORS LLC | 0 | 1,061,665 | +1,061,665 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 965,000 | 1,003,562 | +38,562 | 0.97 | 1.19 | +0.22 | buy |
| Opaleye Management Inc. | 935,000 | 935,000 | 0 | 0.86 | 0.59 | -0.27 | hold |
| GREAT POINT PARTNERS LLC | 842,106 | 842,106 | 0 | 1.44 | 1.37 | -0.06 | hold |
| Soleus Capital Management, L.P. | 842,106 | 842,106 | 0 | 0.24 | 0.20 | -0.04 | hold |
| Boxer Capital Management, LLC | 842,106 | 842,106 | 0 | 0.77 | 0.44 | -0.33 | hold |
| BANK OF AMERICA CORP /DE/ | 125,941 | 812,059 | +686,118 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 157,734 | 786,257 | +628,523 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 699,039 | 767,624 | +68,585 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 653,333 | 691,545 | +38,212 | 0.01 | 0.01 | -0.00 | buy |
| Walleye Capital LLC | 0 | 616,238 | +616,238 | 0.00 | 0.02 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 729,055 | 564,759 | -164,296 | 0.12 | 0.07 | -0.04 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 712,540 | 543,394 | -169,146 | 0.01 | 0.00 | -0.00 | sell |
| Integral Health Asset Management, LLC | 450,000 | 500,000 | +50,000 | 0.17 | 0.14 | -0.02 | buy |
| ADAR1 Capital Management, LLC | 451,918 | 451,918 | 0 | 0.19 | 0.15 | -0.04 | hold |
| Knott David M Jr | 439,300 | 451,000 | +11,700 | 1.82 | 1.65 | -0.17 | buy |
| HighVista Strategies LLC | 0 | 445,799 | +445,799 | 0.00 | 0.70 | +0.70 | buy |
| AdvisorShares Investments LLC | 295,872 | 438,901 | +143,029 | 0.38 | 0.37 | -0.01 | buy |
| Birchview Capital, LP | 409,387 | 408,100 | -1,287 | 1.62 | 1.32 | -0.30 | sell |
| DIADEMA PARTNERS LP | 200,842 | 361,367 | +160,525 | 0.58 | 0.88 | +0.31 | buy |
| PARSONS CAPITAL MANAGEMENT INC/RI | 352,500 | 354,069 | +1,569 | 0.11 | 0.11 | -0.00 | buy |
| Harvest Investment Services, LLC | 0 | 340,890 | +340,890 | 0.00 | 0.36 | +0.36 | buy |
| Woodline Partners LP | 421,052 | 328,421 | -92,631 | 0.01 | 0.01 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 224,846 | 318,902 | +94,056 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 315,788 | 315,788 | 0 | 0.15 | 0.09 | -0.06 | hold |
| Bank of New York Mellon Corp | 0 | 295,623 | +295,623 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 282,717 | +282,717 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 53,081 | 282,717 | +229,636 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 225,067 | +225,067 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 408,095 | 214,915 | -193,180 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 126,672 | 158,033 | +31,361 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 155,713 | +155,713 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 19,566 | 141,443 | +121,877 | 0.01 | 0.06 | +0.05 | buy |
| RHUMBLINE ADVISERS | 0 | 118,108 | +118,108 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 109,474 | +109,474 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 106,456 | +106,456 | 0.00 | 0.00 | +0.00 | buy |
| X-Square Capital, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.18 | +0.18 | buy |
| MGO ONE SEVEN LLC | 100,000 | 100,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Eversept Partners, LP | 277,899 | 93,192 | -184,707 | 0.13 | 0.04 | -0.09 | sell |
| Invesco Ltd. | 22,442 | 89,671 | +67,229 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 130,935 | 88,447 | -42,488 | 0.11 | 0.05 | -0.05 | sell |
| Persistent Asset Partners Ltd | 50,773 | 86,443 | +35,670 | 0.14 | 0.19 | +0.05 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 86,263 | +86,263 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 77,668 | +77,668 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 15,414 | 71,753 | +56,339 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 71,705 | 71,705 | 0 | 0.04 | 0.03 | -0.01 | hold |
| SEI INVESTMENTS CO | 166,614 | 69,375 | -97,239 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 0 | 67,348 | +67,348 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 63,800 | +63,800 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 167,200 | 57,800 | -109,400 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 63,584 | 55,600 | -7,984 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 0 | 55,562 | +55,562 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 88,953 | 51,234 | -37,719 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 0 | 49,202 | +49,202 | 0.00 | 0.08 | +0.08 | buy |
| apricus wealth, LLC | 47,462 | 47,462 | 0 | 0.16 | 0.16 | -0.00 | hold |
| Trexquant Investment LP | 0 | 43,746 | +43,746 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 43,360 | +43,360 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 39,600 | +39,600 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 39,203 | +39,203 | 0.00 | 0.00 | +0.00 | buy |
| AlTi Global, Inc. | 31,975 | 31,975 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Pale Fire Capital SE | 31,650 | 31,650 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 0 | 27,890 | +27,890 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 27,326 | +27,326 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 26,000 | +26,000 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 25,027 | +25,027 | 0.00 | 0.00 | +0.00 | buy |
| Robertson Stephens Wealth Management, LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| State of Wyoming | 12,581 | 20,586 | +8,005 | 0.01 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 19,903 | +19,903 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 19,720 | +19,720 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 17,940 | +17,940 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 16,020 | +16,020 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 8,320 | 14,429 | +6,109 | 0.00 | 0.00 | +0.00 | buy |
| Lido Advisors, LLC | 13,905 | 13,905 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Keebeck Wealth Management | 13,000 | 13,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| ProShare Advisors LLC | 0 | 12,381 | +12,381 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 12,093 | +12,093 | 0.00 | 0.01 | +0.01 | buy |
| Scientech Research LLC | 14,609 | 11,826 | -2,783 | 0.08 | 0.07 | -0.02 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 10,637 | +10,637 | 0.00 | 0.00 | +0.00 | buy |
| World Investment Advisors | 10,444 | 10,444 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bedel Financial Consulting, Inc. | 10,000 | 10,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Legal & General Group Plc | 0 | 9,181 | +9,181 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 8,582 | +8,582 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 6,816 | +6,816 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 6,186 | +6,186 | 0.00 | 0.00 | +0.00 | buy |