| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BML Capital Management, LLC | 14,250,000 | 14,250,000 | 0 | 37.97 | 34.38 | -3.59 | hold |
| Deep Track Capital, LP | 0 | 9,345,000 | +9,345,000 | 0.00 | 0.72 | +0.72 | buy |
| BlackRock, Inc. | 6,804,841 | 7,407,065 | +602,224 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 6,804,072 | +6,804,072 | 0.00 | 0.27 | +0.27 | buy |
| Vivo Capital, LLC | 8,888,888 | 6,666,666 | -2,222,222 | 1.73 | 2.08 | +0.35 | sell |
| Frazier Life Sciences Management, L.P. | 0 | 4,925,374 | +4,925,374 | 0.00 | 0.48 | +0.48 | buy |
| Rock Springs Capital Management LP | 4,453,741 | 4,472,650 | +18,909 | 0.69 | 0.99 | +0.30 | buy |
| Decheng Capital LLC | 4,041,736 | 4,041,736 | 0 | 1.64 | 2.29 | +0.66 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,371,000 | 3,871,000 | +500,000 | 0.02 | 0.02 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 3,361,328 | +3,361,328 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 3,415,390 | 2,746,302 | -669,088 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,392,772 | 2,423,691 | +30,919 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,205,281 | 2,249,319 | +1,044,038 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 1,506,403 | 2,008,746 | +502,343 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 0 | 1,699,116 | +1,699,116 | 0.00 | 0.21 | +0.21 | buy |
| Palo Alto Investors LP | 1,566,840 | 1,613,430 | +46,590 | 0.66 | 0.93 | +0.27 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 2,122,399 | 1,539,791 | -582,608 | 0.01 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 742,009 | 1,485,623 | +743,614 | 0.01 | 0.02 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 1,434,164 | 1,418,360 | -15,804 | 0.01 | 0.01 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 987,351 | 997,850 | +10,499 | 0.00 | 0.00 | +0.00 | buy |
| Aldebaran Capital, LLC | 954,262 | 947,162 | -7,100 | 2.58 | 2.72 | +0.14 | sell |
| D. E. Shaw & Co., Inc. | 2,096,651 | 900,804 | -1,195,847 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,053,246 | 756,127 | -297,119 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 664,258 | 728,225 | +63,967 | 0.00 | 0.00 | +0.00 | buy |
| Three Bridge Wealth Advisors, LLC | 714,823 | 714,823 | 0 | 0.57 | 0.74 | +0.17 | hold |
| MARSHALL WACE, LLP | 485,501 | 712,984 | +227,483 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 632,502 | 588,691 | -43,811 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 270,850 | 511,461 | +240,611 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,125,331 | 502,631 | -622,700 | 0.01 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 68,190 | 502,290 | +434,100 | 0.00 | 0.01 | +0.01 | buy |
| Monashee Investment Management LLC | 0 | 500,000 | +500,000 | 0.00 | 1.02 | +1.02 | buy |
| Logos Global Management LP | 600,000 | 500,000 | -100,000 | 0.12 | 0.10 | -0.02 | sell |
| JPMORGAN CHASE & CO | 625,963 | 486,633 | -139,330 | 0.00 | 0.00 | -0.00 | sell |
| Aisling Capital Management LP | 434,455 | 434,455 | 0 | 0.27 | 0.34 | +0.07 | hold |
| Bollard Group LLC | 804,445 | 431,631 | -372,814 | 0.06 | 0.05 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 574,213 | 395,637 | -178,576 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 0 | 391,918 | +391,918 | 0.00 | 0.11 | +0.11 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 916,846 | 379,930 | -536,916 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 366,490 | +366,490 | 0.00 | 0.98 | +0.98 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 330,019 | 330,019 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Russell Investments Group, Ltd. | 9,785 | 308,165 | +298,380 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 305,948 | 305,836 | -112 | 0.00 | 0.00 | +0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 269,684 | 266,448 | -3,236 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 284,604 | 260,990 | -23,614 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 264,359 | 257,156 | -7,203 | 0.00 | 0.00 | +0.00 | sell |
| SEI INVESTMENTS CO | 0 | 217,154 | +217,154 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 209,903 | 214,935 | +5,032 | 0.00 | 0.00 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 0 | 213,405 | +213,405 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 203,517 | 207,024 | +3,507 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 362,538 | 206,814 | -155,724 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 447,175 | 194,510 | -252,665 | 0.00 | 0.00 | -0.00 | sell |
| Informed Momentum Co LLC | 0 | 178,378 | +178,378 | 0.00 | 0.08 | +0.08 | buy |
| Assenagon Asset Management S.A. | 154,554 | 177,283 | +22,729 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 45,807 | 176,353 | +130,546 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 140,167 | 156,725 | +16,558 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 51,171 | 152,088 | +100,917 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 613,986 | 132,426 | -481,560 | 0.14 | 0.03 | -0.11 | sell |
| AMERICAN CENTURY COMPANIES INC | 77,568 | 118,702 | +41,134 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 237,830 | 118,020 | -119,810 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 88,966 | 98,175 | +9,209 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 112,912 | 97,774 | -15,138 | 0.01 | 0.01 | -0.00 | sell |
| RHUMBLINE ADVISERS | 71,804 | 75,401 | +3,597 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 57,670 | 72,540 | +14,870 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 103,792 | 72,408 | -31,384 | 0.00 | 0.00 | -0.00 | sell |
| CenterBook Partners LP | 0 | 66,598 | +66,598 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 25,597 | 43,870 | +18,273 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,568 | 43,589 | +1,021 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 41,873 | 41,873 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 39,701 | 39,701 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 104,465 | 36,262 | -68,203 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 0 | 33,007 | +33,007 | 0.00 | 0.04 | +0.04 | buy |
| Diversified Trust Co | 0 | 29,455 | +29,455 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 27,300 | 27,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SG Americas Securities, LLC | 15,423 | 26,767 | +11,344 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 28,998 | 25,398 | -3,600 | 0.00 | 0.00 | +0.00 | sell |
| Vontobel Holding Ltd. | 26,000 | 25,000 | -1,000 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 11,545 | 22,471 | +10,926 | 0.00 | 0.01 | +0.01 | buy |
| Neuberger Berman Group LLC | 18,955 | 22,062 | +3,107 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 143,414 | 21,508 | -121,906 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 21,516 | 21,445 | -71 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 17,655 | 21,401 | +3,746 | 0.00 | 0.01 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 19,700 | 19,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 46,646 | 19,196 | -27,450 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 21,553 | 18,696 | -2,857 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 0 | 18,294 | +18,294 | 0.00 | 0.00 | +0.00 | buy |
| CRA Financial Services, LLC | 17,782 | 17,782 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Vanguard Personalized Indexing Management, LLC | 0 | 17,558 | +17,558 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Asset Management Inc | 17,428 | 17,428 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ExodusPoint Capital Management, LP | 0 | 16,895 | +16,895 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 16,820 | +16,820 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 17,248 | 16,311 | -937 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 0 | 16,000 | +16,000 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 15,200 | 15,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 0 | 13,380 | +13,380 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 10,651 | 11,749 | +1,098 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 16,668 | 11,216 | -5,452 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 11,002 | 11,000 | -2 | 0.00 | 0.00 | +0.00 | sell |
| MERCER GLOBAL ADVISORS INC /ADV | 10,167 | 10,595 | +428 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 0 | 10,088 | +10,088 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 9,267 | 9,267 | 0 | 0.00 | 0.00 | +0.00 | hold |