| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BML Capital Management, LLC | 9,395,934 | 12,988,134 | +3,592,200 | 7.80 | 10.46 | +2.66 | buy |
| VANGUARD GROUP INC | 4,929,775 | 4,687,551 | -242,224 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,273,492 | 3,336,850 | +63,358 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 3,282,982 | 3,320,206 | +37,224 | 0.01 | 0.01 | -0.00 | buy |
| Rock Springs Capital Management LP | 2,753,495 | 2,753,495 | 0 | 0.09 | 0.09 | +0.00 | hold |
| Stonepine Capital Management, LLC | 0 | 1,927,446 | +1,927,446 | 0.00 | 1.93 | +1.93 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 2,135,367 | 1,913,449 | -221,918 | 0.01 | 0.01 | -0.00 | sell |
| Trium Capital LLP | 0 | 1,892,050 | +1,892,050 | 0.00 | 0.74 | +0.74 | buy |
| TWO SIGMA ADVISERS, LP | 1,451,100 | 1,436,900 | -14,200 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,329,616 | 1,113,072 | -216,544 | 0.00 | 0.00 | -0.00 | sell |
| Bain Capital Life Sciences Investors, LLC | 3,000,000 | 1,000,000 | -2,000,000 | 0.30 | 0.12 | -0.18 | sell |
| Qube Research & Technologies Ltd | 1,212,260 | 940,752 | -271,508 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 957,021 | 923,313 | -33,708 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,673,400 | 922,200 | -751,200 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 145,812 | 916,620 | +770,808 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 930,003 | 875,216 | -54,787 | 0.00 | 0.00 | -0.00 | sell |
| Aldebaran Capital, LLC | 0 | 858,152 | +858,152 | 0.00 | 0.88 | +0.88 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,565,054 | 774,137 | -790,917 | 0.00 | 0.00 | -0.00 | sell |
| Samsara BioCapital, LLC | 696,171 | 696,171 | 0 | 0.13 | 0.16 | +0.03 | hold |
| FMR LLC | 671,828 | 689,353 | +17,525 | 0.00 | 0.00 | -0.00 | buy |
| Palo Alto Investors LP | 569,832 | 569,832 | 0 | 0.08 | 0.07 | -0.01 | hold |
| NORTHERN TRUST CORP | 562,224 | 520,469 | -41,755 | 0.00 | 0.00 | -0.00 | sell |
| Acuitas Investments, LLC | 461,663 | 464,120 | +2,457 | 0.29 | 0.27 | -0.02 | buy |
| Aisling Capital Management LP | 434,455 | 434,455 | 0 | 0.18 | 0.21 | +0.02 | hold |
| AQR CAPITAL MANAGEMENT LLC | 612,205 | 386,177 | -226,028 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 679,137 | 336,677 | -342,460 | 0.07 | 0.03 | -0.04 | sell |
| JANE STREET GROUP, LLC | 331,740 | 335,009 | +3,269 | 0.00 | 0.00 | -0.00 | buy |
| HighTower Advisors, LLC | 312,614 | 312,714 | +100 | 0.00 | 0.00 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 264,377 | 264,377 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 419,334 | 260,706 | -158,628 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 123,460 | 206,600 | +83,140 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,338,439 | 196,621 | -1,141,818 | 0.00 | 0.00 | -0.00 | sell |
| Alpine Global Management, LLC | 0 | 177,909 | +177,909 | 0.00 | 0.03 | +0.03 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 150,700 | +150,700 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 109,767 | 139,400 | +29,633 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 247,675 | 118,459 | -129,216 | 0.00 | 0.00 | -0.00 | sell |
| Centiva Capital, LP | 0 | 117,966 | +117,966 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 100,773 | 115,580 | +14,807 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 114,806 | +114,806 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 107,929 | +107,929 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 0 | 94,687 | +94,687 | 0.00 | 0.00 | +0.00 | buy |
| Marquette Asset Management, LLC | 83,979 | 83,979 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Verition Fund Management LLC | 53,835 | 82,883 | +29,048 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 81,005 | +81,005 | 0.00 | 0.00 | +0.00 | buy |
| Paloma Partners Management Co | 0 | 79,200 | +79,200 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 89,061 | 76,759 | -12,302 | 0.00 | 0.00 | -0.00 | sell |
| Deuterium Capital Management, LLC | 79,993 | 72,091 | -7,902 | 0.18 | 0.13 | -0.04 | sell |
| Engineers Gate Manager LP | 57,138 | 60,536 | +3,398 | 0.00 | 0.00 | -0.00 | buy |
| BBR PARTNERS, LLC | 60,000 | 60,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Cubist Systematic Strategies, LLC | 44,902 | 44,783 | -119 | 0.00 | 0.00 | +0.00 | sell |
| Mariner, LLC | 39,800 | 42,196 | +2,396 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 97,220 | 42,005 | -55,215 | 0.00 | 0.00 | -0.00 | sell |
| Cambridge Investment Research Advisors, Inc. | 41,873 | 41,873 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 68,266 | 40,245 | -28,021 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 35,300 | +35,300 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 33,183 | 33,183 | 0 | 0.00 | 0.00 | -0.00 | hold |
| XTX Topco Ltd | 123,100 | 24,452 | -98,648 | 0.02 | 0.00 | -0.02 | sell |
| Jump Financial, LLC | 0 | 22,524 | +22,524 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 5,267 | 20,066 | +14,799 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 20,000 | 20,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Point72 (DIFC) Ltd | 0 | 18,319 | +18,319 | 0.00 | 0.00 | +0.00 | buy |
| Marex Group plc | 14,400 | 14,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Catalyst Funds Management Pty Ltd | 0 | 14,000 | +14,000 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 13,910 | +13,910 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 17,450 | 13,701 | -3,749 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 12,335 | 13,471 | +1,136 | 0.00 | 0.00 | -0.00 | buy |
| Neuberger Berman Group LLC | 12,515 | 12,656 | +141 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 15,801 | 11,780 | -4,021 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 0 | 11,622 | +11,622 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 11,500 | 11,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Baader Bank Aktiengesellschaft | 0 | 10,466 | +10,466 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 28,064 | 10,166 | -17,898 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 8,259 | 9,539 | +1,280 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,627 | 8,372 | -5,255 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 133,831 | 5,549 | -128,282 | 0.01 | 0.00 | -0.01 | sell |
| Russell Investments Group, Ltd. | 62,772 | 3,550 | -59,222 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 0 | 3,497 | +3,497 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 241,101 | 3,399 | -237,702 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 31,552 | 2,128 | -29,424 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 0 | 1,632 | +1,632 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,704 | 586 | -7,118 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 0 | 527 | +527 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Capital Advisors, Ltd. LLC | 0 | 454 | +454 | 0.00 | 0.00 | 0.00 | buy |
| CWM, LLC | 77 | 268 | +191 | 0.00 | 0.00 | 0.00 | buy |
| Daiwa Securities Group Inc. | 248 | 248 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Farther Finance Advisors, LLC | 99 | 99 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Covestor Ltd | 63 | 62 | -1 | 0.00 | 0.00 | 0.00 | sell |
| INNEALTA CAPITAL, LLC | 0 | 56 | +56 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 30,984 | 0 | -30,984 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 6,900 | 0 | -6,900 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,982 | 0 | -6,982 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 60,400 | 0 | -60,400 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 17,654 | 0 | -17,654 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 32,843 | 0 | -32,843 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 232,771 | 0 | -232,771 | 0.00 | 0.00 | -0.00 | sell |
| Blackstone Inc. | 13,033 | 0 | -13,033 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 16,114 | 0 | -16,114 | 0.00 | 0.00 | -0.00 | sell |
| Avior Wealth Management, LLC | 14 | 0 | -14 | 0.00 | 0.00 | -0.00 | sell |
| FNY Investment Advisers, LLC | 10,000 | 0 | -10,000 | 0.01 | 0.00 | -0.01 | sell |