| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BML Capital Management, LLC | 14,250,000 | 14,250,000 | 0 | 17.65 | 15.50 | -2.14 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 9,627,304 | 9,627,304 | 0 | 0.03 | 0.02 | -0.00 | hold |
| Vivo Capital, LLC | 8,888,888 | 8,888,888 | 0 | 1.80 | 1.29 | -0.51 | hold |
| VANGUARD GROUP INC | 4,970,254 | 6,662,063 | +1,691,809 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,361,037 | 5,514,879 | +4,153,842 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 5,046,309 | 4,769,309 | -277,000 | 0.44 | 0.42 | -0.02 | sell |
| Decheng Capital LLC | 4,041,736 | 4,041,736 | 0 | 1.73 | 1.45 | -0.29 | hold |
| MILLENNIUM MANAGEMENT LLC | 4,134,148 | 3,837,380 | -296,768 | 0.01 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 2,415,584 | 3,540,192 | +1,124,608 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 2,944,512 | 2,800,282 | -144,230 | 0.01 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,182,737 | 2,464,779 | +1,282,042 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 2,195,191 | 2,433,850 | +238,659 | 0.01 | 0.01 | -0.00 | buy |
| MARSHALL WACE, LLP | 2,312,926 | 2,292,449 | -20,477 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 2,222,222 | 1,850,000 | -372,222 | 0.60 | 0.35 | -0.25 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 951,394 | 1,464,778 | +513,384 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 776,028 | 1,390,028 | +614,000 | 0.23 | 0.42 | +0.19 | buy |
| CITADEL ADVISORS LLC | 1,122,081 | 1,143,806 | +21,725 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 407,525 | 1,006,893 | +599,368 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 923,313 | 1,006,549 | +83,236 | 0.00 | 0.00 | -0.00 | buy |
| Aldebaran Capital, LLC | 1,007,958 | 993,698 | -14,260 | 1.46 | 1.39 | -0.07 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 865,011 | 797,134 | -67,877 | 0.01 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 269,086 | 766,255 | +497,169 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 858,400 | 764,300 | -94,100 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 820,264 | 749,660 | -70,604 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 498,721 | 623,792 | +125,071 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 1,350,820 | 509,350 | -841,470 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 527,842 | 491,300 | -36,542 | 2.69 | 0.69 | -2.00 | sell |
| CANTOR FITZGERALD, L. P. | 695,573 | 451,120 | -244,453 | 0.04 | 0.02 | -0.02 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 288,719 | 443,319 | +154,600 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 458,184 | 442,247 | -15,937 | 0.00 | 0.00 | -0.00 | sell |
| Aisling Capital Management LP | 434,455 | 434,455 | 0 | 0.23 | 0.17 | -0.06 | hold |
| Squarepoint Ops LLC | 348,917 | 390,583 | +41,666 | 0.00 | 0.00 | -0.00 | buy |
| HighTower Advisors, LLC | 316,064 | 321,817 | +5,753 | 0.00 | 0.00 | -0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 250,805 | 277,259 | +26,454 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 33,079 | 261,298 | +228,219 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 237,830 | +237,830 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 13,573 | 215,262 | +201,689 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 354,849 | 207,273 | -147,576 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 681,553 | 184,585 | -496,968 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 123,100 | 166,367 | +43,267 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 555,953 | 156,572 | -399,381 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 119,001 | 156,337 | +37,336 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 57,079 | 135,329 | +78,250 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 84,965 | +84,965 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 64,200 | +64,200 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 62,840 | +62,840 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 56,344 | +56,344 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 67,933 | 53,359 | -14,574 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 49,622 | +49,622 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 30,516 | 46,969 | +16,453 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 44,731 | +44,731 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 41,873 | 41,873 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALGERT GLOBAL LLC | 39,850 | 39,850 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quadrature Capital Ltd | 39,331 | 38,250 | -1,081 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 34,131 | +34,131 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 35,000 | 32,700 | -2,300 | 0.06 | 0.05 | -0.01 | sell |
| CITIGROUP INC | 6,149 | 31,205 | +25,056 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 26,879 | +26,879 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 22,000 | 26,000 | +4,000 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 23,917 | +23,917 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 37,969 | 21,010 | -16,959 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 0 | 19,700 | +19,700 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 18,613 | +18,613 | 0.00 | 0.00 | +0.00 | buy |
| CRA Financial Services, LLC | 0 | 17,782 | +17,782 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 40,242 | 17,589 | -22,653 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 7,479 | 16,773 | +9,294 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 15,200 | +15,200 | 0.00 | 0.00 | +0.00 | buy |
| Marex Group plc | 14,400 | 14,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Neuberger Berman Group LLC | 12,656 | 12,656 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CIBC WORLD MARKETS CORP | 0 | 11,184 | +11,184 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 11,009 | 11,004 | -5 | 0.00 | 0.00 | -0.00 | sell |
| Jefferies Financial Group Inc. | 40,200 | 11,000 | -29,200 | 0.00 | 0.00 | -0.00 | sell |
| MERCER GLOBAL ADVISORS INC /ADV | 10,220 | 10,220 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 0 | 9,267 | +9,267 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 8,242 | +8,242 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 5,664 | +5,664 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 3,100 | +3,100 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 2,451 | +2,451 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 2,448 | +2,448 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 1,336 | +1,336 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 1,292 | +1,292 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 2,942 | 902 | -2,040 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 2,094 | 742 | -1,352 | 0.00 | 0.00 | -0.00 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 0 | 458 | +458 | 0.00 | 0.00 | +0.00 | buy |
| Capital Advisors, Ltd. LLC | 454 | 454 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 318 | 318 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 67 | 267 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 150 | 150 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 99 | 99 | 0 | 0.00 | 0.00 | -0.00 | hold |
| OMERS ADMINISTRATION Corp | 175,900 | 0 | -175,900 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 70,502 | 0 | -70,502 | 0.00 | 0.00 | -0.00 | sell |
| Graham Capital Management, L.P. | 177,558 | 0 | -177,558 | 0.01 | 0.00 | -0.01 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 4,666,667 | 0 | -4,666,667 | 0.12 | 0.00 | -0.12 | sell |
| ALPS ADVISORS INC | 78,782 | 0 | -78,782 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 11,791 | 0 | -11,791 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 12,200 | 0 | -12,200 | 0.00 | 0.00 | -0.00 | sell |
| CAPSTONE INVESTMENT ADVISORS, LLC | 23,564 | 0 | -23,564 | 0.00 | 0.00 | -0.00 | sell |
| OXFORD ASSET MANAGEMENT LLP | 41,723 | 0 | -41,723 | 0.03 | 0.00 | -0.03 | sell |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 29,316 | 0 | -29,316 | 0.00 | 0.00 | -0.00 | sell |