| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 6,804,072 | 12,723,026 | +5,918,954 | 0.27 | 0.58 | +0.31 | buy |
| BlackRock, Inc. | 7,407,065 | 10,037,008 | +2,629,943 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 1,946,482 | +1,946,482 | 0.00 | 1.15 | +1.15 | buy |
| STATE STREET CORP | 2,008,746 | 3,255,340 | +1,246,594 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 502,290 | 1,356,152 | +853,862 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,423,691 | 3,190,058 | +766,367 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 391,918 | 1,042,467 | +650,549 | 0.11 | 0.34 | +0.22 | buy |
| BRAIDWELL LP | 1,699,116 | 2,142,348 | +443,232 | 0.21 | 0.42 | +0.21 | buy |
| ORBIMED ADVISORS LLC | 0 | 421,500 | +421,500 | 0.00 | 0.04 | +0.04 | buy |
| TFG Asset Management GP Ltd | 0 | 400,000 | +400,000 | 0.00 | 0.34 | +0.34 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 346,058 | +346,058 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 502,631 | 817,531 | +314,900 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 728,225 | 998,763 | +270,538 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,871,000 | 4,071,000 | +200,000 | 0.02 | 0.03 | +0.01 | buy |
| Nuveen, LLC | 118,020 | 278,404 | +160,384 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 148,855 | +148,855 | 0.00 | 0.07 | +0.07 | buy |
| FMR LLC | 176,353 | 313,850 | +137,497 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,485,623 | 1,611,054 | +125,431 | 0.02 | 0.03 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 110,412 | +110,412 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 7,826 | 117,786 | +109,960 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 16,820 | 120,000 | +103,180 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,539,791 | 1,641,472 | +101,681 | 0.01 | 0.01 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 98,000 | +98,000 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 260,990 | 346,058 | +85,068 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 0 | 77,168 | +77,168 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 207,024 | 282,599 | +75,575 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 36,262 | 108,648 | +72,386 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 75,401 | 143,216 | +67,815 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 16,000 | 81,400 | +65,400 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 156,725 | 221,599 | +64,874 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 152,088 | 206,647 | +54,559 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 308,165 | 362,494 | +54,329 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 66,598 | 118,228 | +51,630 | 0.01 | 0.03 | +0.02 | buy |
| BARCLAYS PLC | 21,508 | 73,010 | +51,502 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 50,291 | +50,291 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 206,814 | 257,001 | +50,187 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 98,175 | 141,749 | +43,574 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 997,850 | 1,040,955 | +43,105 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 15,200 | 57,000 | +41,800 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 39,701 | 76,270 | +36,569 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 379,930 | 412,549 | +32,619 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 30,486 | +30,486 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 214,935 | 243,028 | +28,093 | 0.00 | 0.00 | -0.00 | buy |
| Vivo Capital, LLC | 6,666,666 | 6,694,637 | +27,971 | 2.08 | 3.23 | +1.16 | buy |
| State of Wyoming | 0 | 27,439 | +27,439 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 43,870 | 69,699 | +25,829 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 21,997 | +21,997 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 588,691 | 609,158 | +20,467 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 19,576 | +19,576 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 19,700 | 38,826 | +19,126 | 0.00 | 0.00 | +0.00 | buy |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 0 | 16,072 | +16,072 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 29,455 | 45,523 | +16,068 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 21,445 | 35,524 | +14,079 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 13,521 | +13,521 | 0.00 | 0.02 | +0.02 | buy |
| XPONANCE, INC. | 0 | 11,273 | +11,273 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 43,589 | 54,578 | +10,989 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 257,156 | 267,498 | +10,342 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 266,448 | 275,611 | +9,163 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 26,767 | 34,814 | +8,047 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,398 | 32,406 | +7,008 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 13,380 | 20,270 | +6,890 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 16,311 | 23,104 | +6,793 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 5,677 | +5,677 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 19,196 | 24,668 | +5,472 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,006 | 9,501 | +4,495 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 3,787 | +3,787 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 3,867 | 7,510 | +3,643 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 8,242 | 11,518 | +3,276 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 511,461 | 513,840 | +2,379 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 9,267 | 10,756 | +1,489 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 18,696 | 20,095 | +1,399 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 11,749 | 12,718 | +969 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 347 | 1,175 | +828 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 21,401 | 22,228 | +827 | 0.01 | 0.01 | +0.00 | buy |
| Arax Advisory Partners | 0 | 786 | +786 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 0 | 458 | +458 | 0.00 | 0.00 | +0.00 | buy |
| M&T BANK CORP | 10,088 | 10,516 | +428 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 391 | +391 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 336 | +336 | 0.00 | 0.00 | +0.00 | buy |
| ZIONS BANCORPORATION, NATIONAL ASSOCIATION /UT/ | 0 | 156 | +156 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,419 | 2,553 | +134 | 0.00 | 0.00 | +0.00 | buy |
| SJS Investment Consulting Inc. | 0 | 102 | +102 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 102 | +102 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 10,595 | 10,688 | +93 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 56 | +56 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 49 | 87 | +38 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Palo Alto Investors LP | 1,613,430 | 1,613,430 | 0 | 0.93 | 1.18 | +0.25 | hold |
| Cambridge Investment Research Advisors, Inc. | 41,873 | 41,873 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bollard Group LLC | 431,631 | 431,631 | 0 | 0.05 | 0.07 | +0.02 | hold |
| Capital Advisors, Ltd. LLC | 454 | 454 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 357 | 357 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rockefeller Capital Management L.P. | 6,112 | 6,112 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Truvestments Capital LLC | 150 | 150 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CRA Financial Services, LLC | 17,782 | 17,782 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Aisling Capital Management LP | 434,455 | 434,455 | 0 | 0.34 | 0.49 | +0.15 | hold |
| SBI Securities Co., Ltd. | 67 | 67 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Deep Track Capital, LP | 9,345,000 | 9,345,000 | 0 | 0.72 | 0.73 | +0.01 | hold |
| Frazier Life Sciences Management, L.P. | 4,925,374 | 4,925,374 | 0 | 0.48 | 0.57 | +0.09 | hold |