| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 6,804,072 | 12,723,026 | +5,918,954 | 0.27 | 0.58 | +0.31 | buy |
| BML Capital Management, LLC | 14,250,000 | 11,975,000 | -2,275,000 | 34.38 | 36.18 | +1.80 | sell |
| BlackRock, Inc. | 7,407,065 | 10,037,008 | +2,629,943 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 9,345,000 | 9,345,000 | 0 | 0.72 | 0.73 | +0.01 | hold |
| Vivo Capital, LLC | 6,666,666 | 6,694,637 | +27,971 | 2.08 | 3.23 | +1.16 | buy |
| Frazier Life Sciences Management, L.P. | 4,925,374 | 4,925,374 | 0 | 0.48 | 0.57 | +0.09 | hold |
| Rock Springs Capital Management LP | 4,472,650 | 4,330,532 | -142,118 | 0.99 | 1.12 | +0.13 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,871,000 | 4,071,000 | +200,000 | 0.02 | 0.03 | +0.01 | buy |
| Decheng Capital LLC | 4,041,736 | 4,041,736 | 0 | 2.29 | 2.92 | +0.63 | hold |
| STATE STREET CORP | 2,008,746 | 3,255,340 | +1,246,594 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,423,691 | 3,190,058 | +766,367 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 1,699,116 | 2,142,348 | +443,232 | 0.21 | 0.42 | +0.21 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 3,361,328 | 2,023,470 | -1,337,858 | 0.02 | 0.02 | -0.01 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 1,946,482 | +1,946,482 | 0.00 | 1.15 | +1.15 | buy |
| CITADEL ADVISORS LLC | 2,249,319 | 1,762,081 | -487,238 | 0.01 | 0.01 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 1,539,791 | 1,641,472 | +101,681 | 0.01 | 0.01 | +0.00 | buy |
| Palo Alto Investors LP | 1,613,430 | 1,613,430 | 0 | 0.93 | 1.18 | +0.25 | hold |
| Woodline Partners LP | 1,485,623 | 1,611,054 | +125,431 | 0.02 | 0.03 | +0.01 | buy |
| PANAGORA ASSET MANAGEMENT INC | 502,290 | 1,356,152 | +853,862 | 0.01 | 0.02 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 1,418,360 | 1,209,886 | -208,474 | 0.01 | 0.01 | -0.00 | sell |
| MPM BioImpact LLC | 391,918 | 1,042,467 | +650,549 | 0.11 | 0.34 | +0.22 | buy |
| DEUTSCHE BANK AG\ | 997,850 | 1,040,955 | +43,105 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 728,225 | 998,763 | +270,538 | 0.00 | 0.00 | +0.00 | buy |
| Aldebaran Capital, LLC | 947,162 | 936,731 | -10,431 | 2.72 | 3.72 | +1.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 502,631 | 817,531 | +314,900 | 0.00 | 0.01 | +0.00 | buy |
| Three Bridge Wealth Advisors, LLC | 714,823 | 714,823 | 0 | 0.74 | 0.95 | +0.21 | hold |
| GOLDMAN SACHS GROUP INC | 588,691 | 609,158 | +20,467 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 756,127 | 523,895 | -232,232 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 511,461 | 513,840 | +2,379 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 486,633 | 468,964 | -17,669 | 0.00 | 0.00 | +0.00 | sell |
| Aisling Capital Management LP | 434,455 | 434,455 | 0 | 0.34 | 0.49 | +0.15 | hold |
| Bollard Group LLC | 431,631 | 431,631 | 0 | 0.05 | 0.07 | +0.02 | hold |
| ORBIMED ADVISORS LLC | 0 | 421,500 | +421,500 | 0.00 | 0.04 | +0.04 | buy |
| D. E. Shaw & Co., Inc. | 900,804 | 414,499 | -486,305 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 379,930 | 412,549 | +32,619 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 0 | 400,000 | +400,000 | 0.00 | 0.34 | +0.34 | buy |
| Russell Investments Group, Ltd. | 308,165 | 362,494 | +54,329 | 0.00 | 0.00 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 346,058 | +346,058 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 260,990 | 346,058 | +85,068 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 176,353 | 313,850 | +137,497 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 207,024 | 282,599 | +75,575 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 118,020 | 278,404 | +160,384 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 266,448 | 275,611 | +9,163 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 257,156 | 267,498 | +10,342 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 366,490 | 257,675 | -108,815 | 0.98 | 0.86 | -0.12 | sell |
| UBS Group AG | 206,814 | 257,001 | +50,187 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 214,935 | 243,028 | +28,093 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 156,725 | 221,599 | +64,874 | 0.00 | 0.00 | +0.00 | buy |
| HighTower Advisors, LLC | 305,836 | 217,524 | -88,312 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 152,088 | 206,647 | +54,559 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 500,000 | 200,000 | -300,000 | 0.10 | 0.05 | -0.05 | sell |
| Informed Momentum Co LLC | 178,378 | 171,327 | -7,051 | 0.08 | 0.08 | +0.00 | sell |
| Assenagon Asset Management S.A. | 177,283 | 154,554 | -22,729 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 0 | 148,855 | +148,855 | 0.00 | 0.07 | +0.07 | buy |
| RHUMBLINE ADVISERS | 75,401 | 143,216 | +67,815 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 98,175 | 141,749 | +43,574 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 217,154 | 138,778 | -78,376 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 395,637 | 133,068 | -262,569 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 16,820 | 120,000 | +103,180 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 66,598 | 118,228 | +51,630 | 0.01 | 0.03 | +0.02 | buy |
| CITIGROUP INC | 7,826 | 117,786 | +109,960 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 110,412 | +110,412 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 36,262 | 108,648 | +72,386 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 98,000 | +98,000 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 16,000 | 81,400 | +65,400 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 0 | 77,168 | +77,168 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 39,701 | 76,270 | +36,569 | 0.00 | 0.01 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 330,019 | 75,019 | -255,000 | 0.02 | 0.01 | -0.02 | sell |
| BARCLAYS PLC | 21,508 | 73,010 | +51,502 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 43,870 | 69,699 | +25,829 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 72,408 | 60,259 | -12,149 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 15,200 | 57,000 | +41,800 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 43,589 | 54,578 | +10,989 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 50,291 | +50,291 | 0.00 | 0.02 | +0.02 | buy |
| Diversified Trust Co | 29,455 | 45,523 | +16,068 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 41,873 | 41,873 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 19,700 | 38,826 | +19,126 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 21,445 | 35,524 | +14,079 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 26,767 | 34,814 | +8,047 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 25,398 | 32,406 | +7,008 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 30,486 | +30,486 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 27,439 | +27,439 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 27,300 | 27,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 19,196 | 24,668 | +5,472 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 16,311 | 23,104 | +6,793 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 21,401 | 22,228 | +827 | 0.01 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 21,997 | +21,997 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 13,380 | 20,270 | +6,890 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 18,696 | 20,095 | +1,399 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 19,576 | +19,576 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 22,062 | 19,367 | -2,695 | 0.00 | 0.00 | +0.00 | sell |
| Vontobel Holding Ltd. | 25,000 | 18,000 | -7,000 | 0.00 | 0.00 | -0.00 | sell |
| CRA Financial Services, LLC | 17,782 | 17,782 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 0 | 16,072 | +16,072 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 17,558 | 15,691 | -1,867 | 0.00 | 0.00 | +0.00 | sell |
| Dynamic Technology Lab Private Ltd | 0 | 13,521 | +13,521 | 0.00 | 0.02 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 11,749 | 12,718 | +969 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 22,471 | 12,671 | -9,800 | 0.01 | 0.01 | -0.00 | sell |
| Legal & General Group Plc | 8,242 | 11,518 | +3,276 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 0 | 11,273 | +11,273 | 0.00 | 0.00 | +0.00 | buy |