| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BML Capital Management, LLC | 12,988,134 | 14,250,000 | +1,261,866 | 10.46 | 9.64 | -0.82 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 915,509 | +915,509 | 0.00 | 0.00 | +0.00 | buy |
| Stonepine Capital Management, LLC | 1,927,446 | 2,458,873 | +531,427 | 1.93 | 1.79 | -0.15 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 922,200 | 1,370,700 | +448,500 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 115,580 | 332,406 | +216,826 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 0 | 185,777 | +185,777 | 0.00 | 0.00 | +0.00 | buy |
| Aldebaran Capital, LLC | 858,152 | 1,043,152 | +185,000 | 0.88 | 1.10 | +0.22 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,913,449 | 2,078,287 | +164,838 | 0.01 | 0.01 | +0.00 | buy |
| Acuitas Investments, LLC | 464,120 | 578,139 | +114,019 | 0.27 | 0.30 | +0.02 | buy |
| ADAR1 Capital Management, LLC | 0 | 90,000 | +90,000 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 774,137 | 846,446 | +72,309 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 3,320,206 | 3,371,849 | +51,643 | 0.01 | 0.01 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 150,700 | 199,119 | +48,419 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 94,687 | 140,580 | +45,893 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 27,000 | +27,000 | 0.00 | 0.01 | +0.01 | buy |
| Trium Capital LLP | 1,892,050 | 1,912,990 | +20,940 | 0.74 | 1.01 | +0.27 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 10,740 | +10,740 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 11,780 | 19,770 | +7,990 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 42,196 | 48,101 | +5,905 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 8,372 | 13,722 | +5,350 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 9,539 | 13,798 | +4,259 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 20,066 | 21,909 | +1,843 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,128 | 2,580 | +452 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 0 | 150 | +150 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 76,759 | 76,810 | +51 | 0.00 | 0.00 | -0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Palo Alto Investors LP | 569,832 | 569,832 | 0 | 0.07 | 0.09 | +0.01 | hold |
| BBR PARTNERS, LLC | 60,000 | 60,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Marquette Asset Management, LLC | 83,979 | 83,979 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Cambridge Investment Research Advisors, Inc. | 41,873 | 41,873 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Neuberger Berman Group LLC | 12,656 | 12,656 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 248 | 248 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Arax Advisory Partners | 1,632 | 1,632 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vontobel Holding Ltd. | 20,000 | 20,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rock Springs Capital Management LP | 2,753,495 | 2,753,495 | 0 | 0.09 | 0.10 | +0.01 | hold |
| Capital Advisors, Ltd. LLC | 454 | 454 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Samsara BioCapital, LLC | 696,171 | 696,171 | 0 | 0.16 | 0.15 | -0.01 | hold |
| Aisling Capital Management LP | 434,455 | 434,455 | 0 | 0.21 | 0.19 | -0.02 | hold |
| Frazier Life Sciences Management, L.P. | 264,377 | 264,377 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Catalyst Funds Management Pty Ltd | 14,000 | 14,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Farther Finance Advisors, LLC | 99 | 99 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Marex Group plc | 14,400 | 14,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 139,400 | 139,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TUDOR INVESTMENT CORP ET AL | 33,183 | 33,183 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 923,313 | 923,313 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Jefferies Financial Group Inc. | 11,500 | 11,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| INNEALTA CAPITAL, LLC | 56 | 0 | -56 | 0.00 | 0.00 | -0.00 | sell |
| Covestor Ltd | 62 | 0 | -62 | 0.00 | 0.00 | 0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 3,399 | 3,268 | -131 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 527 | 318 | -209 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 268 | 1 | -267 | 0.00 | 0.00 | 0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 586 | 0 | -586 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 3,550 | 2,765 | -785 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 4,687,551 | 4,685,498 | -2,053 | 0.00 | 0.00 | -0.00 | sell |
| MACQUARIE GROUP LTD | 3,497 | 0 | -3,497 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 5,549 | 0 | -5,549 | 0.00 | 0.00 | -0.00 | sell |
| HighTower Advisors, LLC | 312,714 | 305,814 | -6,900 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 196,621 | 188,721 | -7,900 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 10,166 | 1,085 | -9,081 | 0.00 | 0.00 | -0.00 | sell |
| Baader Bank Aktiengesellschaft | 10,466 | 0 | -10,466 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 13,471 | 2,087 | -11,384 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 11,622 | 0 | -11,622 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 13,701 | 0 | -13,701 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 13,910 | 0 | -13,910 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 18,319 | 92 | -18,227 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 40,245 | 20,393 | -19,852 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 60,536 | 38,794 | -21,742 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 22,524 | 0 | -22,524 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 24,452 | 0 | -24,452 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 35,300 | 0 | -35,300 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 35,794 | 0 | -35,794 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 44,783 | 6,971 | -37,812 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 42,005 | 0 | -42,005 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 107,929 | 52,052 | -55,877 | 0.02 | 0.01 | -0.01 | sell |
| Deuterium Capital Management, LLC | 72,091 | 0 | -72,091 | 0.13 | 0.00 | -0.13 | sell |
| Paloma Partners Management Co | 79,200 | 0 | -79,200 | 0.01 | 0.00 | -0.01 | sell |
| HRT FINANCIAL LP | 81,005 | 0 | -81,005 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 336,677 | 255,032 | -81,645 | 0.03 | 0.02 | -0.00 | sell |
| Verition Fund Management LLC | 82,883 | 0 | -82,883 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 114,806 | 0 | -114,806 | 0.01 | 0.00 | -0.01 | sell |
| Centiva Capital, LP | 117,966 | 0 | -117,966 | 0.01 | 0.00 | -0.01 | sell |
| Man Group plc | 118,459 | 0 | -118,459 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 1,436,900 | 1,301,500 | -135,400 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 689,353 | 545,972 | -143,381 | 0.00 | 0.00 | -0.00 | sell |
| Alpine Global Management, LLC | 177,909 | 0 | -177,909 | 0.03 | 0.00 | -0.03 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,113,072 | 907,916 | -205,156 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 206,600 | 0 | -206,600 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 260,706 | 0 | -260,706 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,336,850 | 3,005,598 | -331,252 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 335,009 | 0 | -335,009 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 386,177 | 0 | -386,177 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 520,469 | 127,225 | -393,244 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 875,216 | 364,567 | -510,649 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 916,620 | 301,556 | -615,064 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 940,752 | 292,845 | -647,907 | 0.00 | 0.00 | -0.00 | sell |
| Bain Capital Life Sciences Investors, LLC | 1,000,000 | 0 | -1,000,000 | 0.12 | 0.00 | -0.12 | sell |