| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BML Capital Management, LLC | 14,250,000 | 14,250,000 | 0 | 9.64 | 21.95 | +12.31 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 9,627,304 | +9,627,304 | 0.00 | 0.04 | +0.04 | buy |
| Vivo Capital, LLC | 0 | 8,888,888 | +8,888,888 | 0.00 | 2.47 | +2.47 | buy |
| Rock Springs Capital Management LP | 2,753,495 | 6,204,309 | +3,450,814 | 0.10 | 0.59 | +0.48 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 4,666,667 | +4,666,667 | 0.00 | 0.15 | +0.15 | buy |
| VANGUARD GROUP INC | 4,685,498 | 4,325,263 | -360,235 | 0.00 | 0.00 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 3,371,849 | 3,293,625 | -78,224 | 0.01 | 0.01 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 0 | 2,799,759 | +2,799,759 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 2,634,065 | +2,634,065 | 0.00 | 0.01 | +0.01 | buy |
| Samsara BioCapital, LLC | 696,171 | 2,385,060 | +1,688,889 | 0.15 | 0.81 | +0.66 | buy |
| Decheng Capital LLC | 0 | 2,266,667 | +2,266,667 | 0.00 | 1.21 | +1.21 | buy |
| Logos Global Management LP | 0 | 2,222,222 | +2,222,222 | 0.00 | 0.64 | +0.64 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,005,598 | 1,959,047 | -1,046,551 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 2,078,287 | 1,744,147 | -334,140 | 0.01 | 0.01 | +0.01 | sell |
| BlackRock, Inc. | 1,711,797 | 1,257,779 | -454,018 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 0 | 1,071,784 | +1,071,784 | 0.00 | 0.00 | +0.00 | buy |
| Aldebaran Capital, LLC | 1,043,152 | 1,016,958 | -26,194 | 1.10 | 2.40 | +1.30 | sell |
| TWO SIGMA ADVISERS, LP | 1,301,500 | 977,400 | -324,100 | 0.00 | 0.01 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 923,313 | 923,313 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Connor, Clark & Lunn Investment Management Ltd. | 332,406 | 908,819 | +576,413 | 0.00 | 0.01 | +0.01 | buy |
| Monashee Investment Management LLC | 0 | 888,888 | +888,888 | 0.00 | 0.30 | +0.30 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,370,700 | 850,519 | -520,181 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 907,916 | 839,270 | -68,646 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 846,446 | 789,597 | -56,849 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Capital LLC | 0 | 718,897 | +718,897 | 0.00 | 0.02 | +0.02 | buy |
| Stonepine Capital Management, LLC | 2,458,873 | 663,405 | -1,795,468 | 1.79 | 1.33 | -0.46 | sell |
| Qube Research & Technologies Ltd | 292,845 | 615,083 | +322,238 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 915,509 | 576,042 | -339,467 | 0.00 | 0.01 | +0.00 | sell |
| Palo Alto Investors LP | 569,832 | 569,832 | 0 | 0.09 | 0.22 | +0.13 | hold |
| JANE STREET GROUP, LLC | 0 | 545,564 | +545,564 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 545,972 | 459,049 | -86,923 | 0.00 | 0.00 | +0.00 | sell |
| Aisling Capital Management LP | 434,455 | 434,455 | 0 | 0.19 | 0.38 | +0.19 | hold |
| GOLDMAN SACHS GROUP INC | 301,556 | 428,587 | +127,031 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 185,777 | 397,362 | +211,585 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 389,333 | +389,333 | 0.00 | 0.73 | +0.73 | buy |
| Ikarian Capital, LLC | 0 | 350,000 | +350,000 | 0.00 | 0.25 | +0.25 | buy |
| STATE STREET CORP | 188,721 | 319,275 | +130,554 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 140,580 | 292,892 | +152,312 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 199,119 | 281,119 | +82,000 | 0.00 | 0.02 | +0.01 | buy |
| HighTower Advisors, LLC | 305,814 | 262,948 | -42,866 | 0.00 | 0.00 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 6,971 | 256,092 | +249,121 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 76,810 | 239,595 | +162,785 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 217,265 | +217,265 | 0.00 | 0.05 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 205,465 | +205,465 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 127,225 | 175,175 | +47,950 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 131,895 | +131,895 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 139,400 | 123,100 | -16,300 | 0.00 | 0.00 | +0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 112,484 | +112,484 | 0.00 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 106,351 | +106,351 | 0.00 | 0.02 | +0.02 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 100,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 38,794 | 93,547 | +54,753 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 88,320 | +88,320 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 2,087 | 59,972 | +57,885 | 0.00 | 0.00 | +0.00 | buy |
| Marquette Asset Management, LLC | 83,979 | 57,911 | -26,068 | 0.02 | 0.02 | +0.01 | sell |
| ALPS ADVISORS INC | 0 | 57,760 | +57,760 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 54,400 | +54,400 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 53,534 | +53,534 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 52,052 | 48,187 | -3,865 | 0.01 | 0.03 | +0.02 | sell |
| XTX Topco Ltd | 0 | 44,685 | +44,685 | 0.00 | 0.01 | +0.01 | buy |
| Cambridge Investment Research Advisors, Inc. | 41,873 | 41,873 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Jefferies Financial Group Inc. | 11,500 | 40,700 | +29,200 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 48,101 | 37,774 | -10,327 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 33,079 | +33,079 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 0 | 27,000 | +27,000 | 0.00 | 0.06 | +0.06 | buy |
| Caption Management, LLC | 0 | 17,960 | +17,960 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 21,909 | 17,919 | -3,990 | 0.00 | 0.00 | +0.00 | sell |
| Vontobel Holding Ltd. | 20,000 | 16,000 | -4,000 | 0.00 | 0.00 | +0.00 | sell |
| Alpine Global Management, LLC | 0 | 15,340 | +15,340 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 20,393 | 15,201 | -5,192 | 0.00 | 0.00 | +0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 14,694 | +14,694 | 0.00 | 0.00 | +0.00 | buy |
| Marex Group plc | 14,400 | 14,400 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Graham Capital Management, L.P. | 0 | 14,172 | +14,172 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 14,000 | 14,000 | 0 | 0.00 | 0.01 | +0.01 | hold |
| Neuberger Berman Group LLC | 12,656 | 12,656 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Invesco Ltd. | 0 | 11,215 | +11,215 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 10,637 | +10,637 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 1,085 | 6,695 | +5,610 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 13,798 | 4,292 | -9,506 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 92 | 3,708 | +3,616 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 2,765 | 2,765 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MAI Capital Management | 0 | 1,500 | +1,500 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,268 | 1,446 | -1,822 | 0.00 | 0.00 | -0.00 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Capital Advisors, Ltd. LLC | 454 | 454 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 318 | 318 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Truvestments Capital LLC | 150 | 150 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Farther Finance Advisors, LLC | 99 | 99 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALGERT GLOBAL LLC | 19,770 | 0 | -19,770 | 0.00 | 0.00 | -0.00 | sell |
| BBR PARTNERS, LLC | 60,000 | 0 | -60,000 | 0.01 | 0.00 | -0.01 | sell |
| GSA CAPITAL PARTNERS LLP | 255,032 | 0 | -255,032 | 0.02 | 0.00 | -0.02 | sell |
| CITADEL ADVISORS LLC | 364,567 | 0 | -364,567 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 10,740 | 0 | -10,740 | 0.00 | 0.00 | -0.00 | sell |
| Daiwa Securities Group Inc. | 248 | 0 | -248 | 0.00 | 0.00 | 0.00 | sell |
| Acuitas Investments, LLC | 578,139 | 0 | -578,139 | 0.30 | 0.00 | -0.30 | sell |
| CWM, LLC | 1 | 0 | -1 | 0.00 | 0.00 | 0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 2,580 | 0 | -2,580 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 1,632 | 0 | -1,632 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 27,000 | 0 | -27,000 | 0.01 | 0.00 | -0.01 | sell |
| Frazier Life Sciences Management, L.P. | 264,377 | 0 | -264,377 | 0.01 | 0.00 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 13,722 | 0 | -13,722 | 0.00 | 0.00 | -0.00 | sell |