| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Velan Capital Investment Management LP | 77,500 | 746,087 | +668,587 | 0.36 | 2.29 | +1.92 | buy |
| Stonepine Capital Management, LLC | 317,782 | 688,200 | +370,418 | 0.91 | 3.10 | +2.19 | buy |
| First Light Asset Management, LLC | 2,554,641 | 2,754,028 | +199,387 | 1.36 | 1.20 | -0.17 | buy |
| HighMark Wealth Management LLC | 0 | 193,811 | +193,811 | 0.00 | 0.68 | +0.68 | buy |
| Meros Investment Management, LP | 79,939 | 150,339 | +70,400 | 0.25 | 0.38 | +0.13 | buy |
| STATE STREET CORP | 320,543 | 375,368 | +54,825 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 45,736 | 94,940 | +49,204 | 0.00 | 0.00 | +0.00 | buy |
| AIGH Capital Management LLC | 1,377,945 | 1,415,255 | +37,310 | 3.61 | 3.87 | +0.26 | buy |
| XTX Topco Ltd | 0 | 33,464 | +33,464 | 0.00 | 0.03 | +0.03 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 24,385 | +24,385 | 0.00 | 0.01 | +0.01 | buy |
| PARADIGM CAPITAL MANAGEMENT INC/NY | 498,500 | 515,265 | +16,765 | 0.17 | 0.14 | -0.03 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 12,609 | +12,609 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 25,194 | 35,613 | +10,419 | 0.03 | 0.03 | -0.00 | buy |
| VANGUARD GROUP INC | 998,853 | 1,006,052 | +7,199 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 346,662 | 349,723 | +3,061 | 0.00 | 0.00 | -0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 382,214 | 383,075 | +861 | 0.06 | 0.04 | -0.01 | buy |
| BFSG, LLC | 0 | 525 | +525 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 337 | +337 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 14,766 | 15,095 | +329 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 2,360 | 2,669 | +309 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,443 | 9,610 | +167 | 0.00 | 0.00 | -0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 53,612 | 53,739 | +127 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 6,672 | 6,685 | +13 | 0.00 | 0.00 | -0.00 | buy |
| NewEdge Advisors, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 2,835,542 | 2,835,542 | 0 | 0.38 | 0.30 | -0.08 | hold |
| Ameritas Investment Partners, Inc. | 1,311 | 1,311 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FEDERATED HERMES, INC. | 712,300 | 712,300 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Nantahala Capital Management, LLC | 1,097,866 | 1,097,866 | 0 | 0.73 | 0.61 | -0.12 | hold |
| Essex Woodlands Management, Inc. | 4,110,709 | 4,110,709 | 0 | 6.73 | 6.76 | +0.03 | hold |
| UP STRATEGIC WEALTH INVESTMENT ADVISORS LLC | 11,000 | 11,000 | 0 | 0.13 | 0.10 | -0.03 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 14,886 | 14,886 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 1,937 | 1,937 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 16,381 | 16,381 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Covestor Ltd | 1 | 0 | -1 | 0.00 | 0.00 | 0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,779 | 1,736 | -43 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 8,043 | 7,975 | -68 | 0.00 | 0.00 | -0.00 | sell |
| PERKINS CAPITAL MANAGEMENT INC | 210,250 | 210,000 | -250 | 1.19 | 0.99 | -0.20 | sell |
| SIMPLEX TRADING, LLC | 1,488 | 0 | -1,488 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 2,247 | 535 | -1,712 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 135,092 | 132,988 | -2,104 | 0.00 | 0.00 | -0.00 | sell |
| Calamos Advisors LLC | 35,970 | 33,776 | -2,194 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,663 | 0 | -2,663 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 45,911 | 42,911 | -3,000 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 103,375 | 97,668 | -5,707 | 0.10 | 0.07 | -0.03 | sell |
| Bank of New York Mellon Corp | 48,512 | 42,385 | -6,127 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 10,200 | 0 | -10,200 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 22,270 | 11,437 | -10,833 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 16,476 | 0 | -16,476 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 795,080 | 776,851 | -18,229 | 1.62 | 1.24 | -0.39 | sell |
| Schonfeld Strategic Advisors LLC | 54,600 | 35,000 | -19,600 | 0.00 | 0.00 | -0.00 | sell |
| TOWNSQUARE CAPITAL LLC | 32,653 | 0 | -32,653 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 37,931 | 0 | -37,931 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 79,000 | 37,000 | -42,000 | 0.01 | 0.00 | -0.01 | sell |
| Kamunting Street Capital Management, L.P. | 95,694 | 0 | -95,694 | 0.79 | 0.00 | -0.79 | sell |
| Worth Venture Partners, LLC | 345,331 | 3,860 | -341,471 | 1.24 | 0.15 | -1.09 | sell |
| Pentwater Capital Management LP | 990,000 | 308,642 | -681,358 | 0.12 | 0.03 | -0.09 | sell |
| UBS Group AG | 688,922 | 0 | -688,922 | 0.00 | 0.00 | -0.00 | sell |