| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| First Light Asset Management, LLC | 1,725,500 | 2,480,264 | +754,764 | 1.37 | 1.88 | +0.51 | buy |
| SECTORAL ASSET MANAGEMENT INC | 178,372 | 525,000 | +346,628 | 0.30 | 0.82 | +0.52 | buy |
| Nantahala Capital Management, LLC | 356,092 | 456,092 | +100,000 | 0.44 | 0.46 | +0.03 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 416,440 | 490,471 | +74,031 | 1.42 | 1.46 | +0.04 | buy |
| Pentwater Capital Management LP | 878,799 | 925,000 | +46,201 | 0.11 | 0.07 | -0.04 | buy |
| Parkman Healthcare Partners LLC | 159,026 | 166,725 | +7,699 | 0.28 | 0.24 | -0.03 | buy |
| TOWNSQUARE CAPITAL LLC | 59,543 | 64,211 | +4,668 | 0.01 | 0.01 | 0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 385,662 | 387,623 | +1,961 | 0.09 | 0.08 | -0.02 | buy |
| Atom Investors LP | 14,212 | 15,574 | +1,362 | 0.05 | 0.03 | -0.03 | buy |
| Portside Wealth Group, LLC | 13,009 | 14,139 | +1,130 | 0.02 | 0.02 | -0.00 | buy |
| MCF Advisors LLC | 957 | 583 | -374 | 0.00 | 0.00 | -0.00 | sell |
| Kamunting Street Capital Management, L.P. | 110,974 | 95,694 | -15,280 | 1.11 | 0.58 | -0.53 | sell |
| Calamos Advisors LLC | 83,054 | 64,585 | -18,469 | 0.00 | 0.00 | -0.00 | sell |
| PURA VIDA INVESTMENTS, LLC | 402,016 | 337,175 | -64,841 | 1.69 | 1.33 | -0.37 | sell |
| Worth Venture Partners, LLC | 413,241 | 314,220 | -99,021 | 2.29 | 1.50 | -0.79 | sell |
| NEXT CENTURY GROWTH INVESTORS LLC | 774,912 | 473,131 | -301,781 | 0.76 | 0.41 | -0.34 | sell |
| AIGH Capital Management LLC | 1,657,945 | 1,252,945 | -405,000 | 6.86 | 4.75 | -2.12 | sell |
| Opaleye Management Inc. | 1,580,000 | 750,000 | -830,000 | 3.83 | 1.95 | -1.88 | sell |