| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| UBS Group AG | 10,989 | 688,922 | +677,933 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 456,092 | 1,097,866 | +641,774 | 0.46 | 0.73 | +0.26 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 490,471 | 795,080 | +304,609 | 1.46 | 1.62 | +0.16 | buy |
| PARADIGM CAPITAL MANAGEMENT INC/NY | 219,500 | 498,500 | +279,000 | 0.10 | 0.17 | +0.07 | buy |
| AIGH Capital Management LLC | 1,252,945 | 1,377,945 | +125,000 | 4.75 | 3.61 | -1.14 | buy |
| Meros Investment Management, LP | 0 | 79,939 | +79,939 | 0.00 | 0.25 | +0.25 | buy |
| First Light Asset Management, LLC | 2,480,264 | 2,554,641 | +74,377 | 1.88 | 1.36 | -0.52 | buy |
| Pentwater Capital Management LP | 925,000 | 990,000 | +65,000 | 0.07 | 0.12 | +0.05 | buy |
| STATE STREET CORP | 278,872 | 320,543 | +41,671 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 37,931 | +37,931 | 0.00 | 0.00 | +0.00 | buy |
| Worth Venture Partners, LLC | 314,220 | 345,331 | +31,111 | 1.50 | 1.24 | -0.26 | buy |
| VANGUARD GROUP INC | 976,003 | 998,853 | +22,850 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 59,000 | 79,000 | +20,000 | 0.01 | 0.01 | -0.00 | buy |
| PERKINS CAPITAL MANAGEMENT INC | 190,500 | 210,250 | +19,750 | 1.51 | 1.19 | -0.32 | buy |
| BARCLAYS PLC | 2,929 | 22,270 | +19,341 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 16,476 | +16,476 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 1,035 | 16,381 | +15,346 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 335,145 | 346,662 | +11,517 | 0.00 | 0.00 | -0.00 | buy |
| Atom Investors LP | 15,574 | 25,194 | +9,620 | 0.03 | 0.03 | +0.00 | buy |
| FMR LLC | 1,731 | 6,672 | +4,941 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 7 | 2,360 | +2,353 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 46,302 | 48,512 | +2,210 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 14,588 | 14,766 | +178 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 1,468 | 1,488 | +20 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 2,835,542 | 2,835,542 | 0 | 0.49 | 0.38 | -0.11 | hold |
| Ameritas Investment Partners, Inc. | 1,311 | 1,311 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FEDERATED HERMES, INC. | 712,300 | 712,300 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Kamunting Street Capital Management, L.P. | 95,694 | 95,694 | 0 | 0.58 | 0.79 | +0.21 | hold |
| Essex Woodlands Management, Inc. | 4,110,709 | 4,110,709 | 0 | 28.99 | 6.73 | -22.26 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 53,612 | 53,612 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 1,937 | 1,937 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 45,911 | 45,911 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Covestor Ltd | 2 | 1 | -1 | 0.00 | 0.00 | 0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 9,464 | 9,443 | -21 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 8,076 | 8,043 | -33 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 2,406 | 2,247 | -159 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 15,271 | 14,886 | -385 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,177 | 1,779 | -398 | 0.00 | 0.00 | -0.00 | sell |
| MCF Advisors LLC | 583 | 0 | -583 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 877 | 0 | -877 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,570 | 2,663 | -907 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 136,835 | 135,092 | -1,743 | 0.00 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 387,623 | 382,214 | -5,409 | 0.08 | 0.06 | -0.02 | sell |
| MetLife Investment Management, LLC | 8,467 | 0 | -8,467 | 0.00 | 0.00 | -0.00 | sell |
| Portside Wealth Group, LLC | 14,139 | 0 | -14,139 | 0.02 | 0.00 | -0.02 | sell |
| Schonfeld Strategic Advisors LLC | 71,300 | 54,600 | -16,700 | 0.01 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 34,100 | 10,200 | -23,900 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 27,539 | 0 | -27,539 | 0.00 | 0.00 | -0.00 | sell |
| Calamos Advisors LLC | 64,585 | 35,970 | -28,615 | 0.00 | 0.00 | -0.00 | sell |
| TOWNSQUARE CAPITAL LLC | 64,211 | 32,653 | -31,558 | 0.01 | 0.00 | -0.01 | sell |
| MILLENNIUM MANAGEMENT LLC | 34,530 | 0 | -34,530 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 35,159 | 0 | -35,159 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 166,725 | 103,375 | -63,350 | 0.24 | 0.10 | -0.15 | sell |
| SANDERS MORRIS HARRIS LLC | 68,168 | 0 | -68,168 | 0.11 | 0.00 | -0.11 | sell |
| Russell Investments Group, Ltd. | 191,483 | 45,736 | -145,747 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 491,919 | 317,782 | -174,137 | 1.31 | 0.91 | -0.40 | sell |
| PURA VIDA INVESTMENTS, LLC | 337,175 | 0 | -337,175 | 1.33 | 0.00 | -1.33 | sell |
| NEXT CENTURY GROWTH INVESTORS LLC | 473,131 | 0 | -473,131 | 0.41 | 0.00 | -0.41 | sell |
| SECTORAL ASSET MANAGEMENT INC | 525,000 | 0 | -525,000 | 0.82 | 0.00 | -0.82 | sell |
| Velan Capital Investment Management LP | 746,087 | 77,500 | -668,587 | 4.88 | 0.36 | -4.52 | sell |
| Opaleye Management Inc. | 750,000 | 0 | -750,000 | 1.95 | 0.00 | -1.95 | sell |