| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,124,928 | 3,065,649 | +1,940,721 | 0.64 | 2.07 | +1.43 | buy |
| Nantahala Capital Management, LLC | 1,915,126 | 3,679,726 | +1,764,600 | 0.41 | 0.78 | +0.37 | buy |
| DAFNA Capital Management LLC | 0 | 1,441,029 | +1,441,029 | 0.00 | 1.11 | +1.11 | buy |
| Stonepine Capital Management, LLC | 1,110,000 | 2,353,099 | +1,243,099 | 1.77 | 5.74 | +3.96 | buy |
| ROYCE & ASSOCIATES LP | 0 | 1,000,064 | +1,000,064 | 0.00 | 0.03 | +0.03 | buy |
| VANGUARD GROUP INC | 903,503 | 1,875,579 | +972,076 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 767,830 | +767,830 | 0.00 | 0.00 | +0.00 | buy |
| PERKINS CAPITAL MANAGEMENT INC | 225,200 | 907,865 | +682,665 | 0.53 | 2.43 | +1.90 | buy |
| Sio Capital Management, LLC | 0 | 630,000 | +630,000 | 0.00 | 0.54 | +0.54 | buy |
| Pentwater Capital Management LP | 500,000 | 1,000,000 | +500,000 | 0.02 | 0.05 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 148,900 | 425,140 | +276,240 | 0.00 | 0.00 | +0.00 | buy |
| AIGH Capital Management LLC | 2,469,373 | 2,662,785 | +193,412 | 2.92 | 3.03 | +0.10 | buy |
| Archon Capital Management LLC | 0 | 150,000 | +150,000 | 0.00 | 0.55 | +0.55 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 174,515 | 311,405 | +136,890 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 133,666 | +133,666 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 0 | 125,000 | +125,000 | 0.00 | 0.31 | +0.31 | buy |
| UP STRATEGIC WEALTH INVESTMENT ADVISORS LLC | 11,000 | 99,888 | +88,888 | 0.03 | 0.30 | +0.27 | buy |
| CITADEL ADVISORS LLC | 0 | 56,510 | +56,510 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 35,755 | +35,755 | 0.00 | 0.07 | +0.07 | buy |
| Walleye Capital LLC | 0 | 30,138 | +30,138 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 112,205 | 135,754 | +23,549 | 0.02 | 0.03 | +0.01 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 18,800 | +18,800 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 31,325 | 47,181 | +15,856 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 16,030 | 31,313 | +15,283 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 14,886 | 28,441 | +13,555 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 12,087 | +12,087 | 0.00 | 0.00 | +0.00 | buy |
| Embree Financial Group | 10,000 | 12,500 | +2,500 | 0.00 | 0.01 | +0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 19,345 | 19,960 | +615 | 0.01 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 314 | +314 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 337 | 337 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Essex Woodlands Management, Inc. | 4,110,709 | 4,110,709 | 0 | 2.97 | 2.87 | -0.10 | hold |
| Capital Advisors, Ltd. LLC | 130 | 130 | 0 | 0.00 | 0.00 | 0.00 | hold |
| HighMark Wealth Management LLC | 2,800 | 2,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PNC FINANCIAL SERVICES GROUP, INC. | 53,612 | 53,612 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 750,000 | 750,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 65,483 | 65,483 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 60 | 0 | -60 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 427,591 | 427,528 | -63 | 0.00 | 0.00 | +0.00 | sell |
| BFSG, LLC | 525 | 0 | -525 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,717 | 923 | -794 | 0.00 | 0.00 | -0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 1,888 | 0 | -1,888 | 0.00 | 0.00 | -0.00 | sell |
| Catalyst Funds Management Pty Ltd | 4,000 | 0 | -4,000 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 11,558 | 6,302 | -5,256 | 0.01 | 0.01 | -0.00 | sell |
| Qube Research & Technologies Ltd | 10,113 | 0 | -10,113 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 12,200 | 0 | -12,200 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 12,549 | 0 | -12,549 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 13,422 | 0 | -13,422 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 51,472 | 0 | -51,472 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 103,000 | 50,700 | -52,300 | 0.01 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 159,052 | 60,476 | -98,576 | 0.00 | 0.00 | -0.00 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 143,199 | 40,088 | -103,111 | 0.04 | 0.01 | -0.02 | sell |
| MARSHALL WACE, LLP | 106,804 | 0 | -106,804 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 191,400 | 0 | -191,400 | 0.00 | 0.00 | -0.00 | sell |
| Velan Capital Investment Management LP | 747,410 | 0 | -747,410 | 2.05 | 0.00 | -2.05 | sell |
| ORBIMED ADVISORS LLC | 2,161,185 | 0 | -2,161,185 | 0.10 | 0.00 | -0.10 | sell |