| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Logos Global Management LP | 0 | 2,200,000 | +2,200,000 | 0.00 | 0.80 | +0.80 | buy |
| MPM BioImpact LLC | 0 | 1,340,960 | +1,340,960 | 0.00 | 0.74 | +0.74 | buy |
| Propel Bio Management, LLC | 0 | 260,000 | +260,000 | 0.00 | 0.52 | +0.52 | buy |
| Simplify Asset Management Inc. | 0 | 200,000 | +200,000 | 0.00 | 0.07 | +0.07 | buy |
| Shay Capital LLC | 0 | 113,662 | +113,662 | 0.00 | 0.11 | +0.11 | buy |
| Opaleye Management Inc. | 2,535,000 | 2,645,000 | +110,000 | 0.90 | 1.99 | +1.09 | buy |
| OPPENHEIMER & CO INC | 0 | 60,415 | +60,415 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,243,399 | 2,303,648 | +60,249 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 741,193 | 798,249 | +57,056 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 849,881 | 897,965 | +48,084 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 42,118 | +42,118 | 0.00 | 0.00 | +0.00 | buy |
| BAILARD, INC. | 0 | 40,900 | +40,900 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 36,000 | +36,000 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 21,063 | 46,206 | +25,143 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 22,735 | +22,735 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 22,693 | +22,693 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 21,608 | +21,608 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 18,441 | +18,441 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 17,817 | +17,817 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 16,839 | +16,839 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 23,915 | 37,974 | +14,059 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 13,561 | +13,561 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 314,178 | 327,692 | +13,514 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 13,274 | +13,274 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 13,074 | +13,074 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 39,648 | 45,736 | +6,088 | 0.01 | 0.02 | +0.01 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 0 | 2,335 | +2,335 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 6,956 | 8,703 | +1,747 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 51,464 | 51,955 | +491 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 3,422,397 | 3,422,675 | +278 | 0.31 | 0.56 | +0.25 | buy |
| Farther Finance Advisors, LLC | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,511 | 3,535 | +24 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 3 | +3 | 0.00 | 0.00 | 0.00 | buy |
| STIFEL FINANCIAL CORP | 10,100 | 10,103 | +3 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 36,502 | 36,502 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Ameritas Investment Partners, Inc. | 3,438 | 3,438 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 4,400,000 | 4,400,000 | 0 | 0.02 | 0.06 | +0.03 | hold |
| UNITED BANK | 28,450 | 28,450 | 0 | 0.00 | 0.01 | +0.01 | hold |
| J. Goldman & Co LP | 137,873 | 137,873 | 0 | 0.01 | 0.02 | +0.01 | hold |
| WealthTrust Axiom LLC | 63,500 | 63,500 | 0 | 0.03 | 0.07 | +0.04 | hold |
| NEA Management Company, LLC | 11,370,376 | 11,370,376 | 0 | 1.02 | 2.44 | +1.42 | hold |
| Steward Partners Investment Advisory, LLC | 25 | 25 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Frazier Life Sciences Management, L.P. | 7,381,090 | 7,381,090 | 0 | 0.53 | 1.07 | +0.55 | hold |
| PFS Partners, LLC | 99,000 | 99,000 | 0 | 0.09 | 0.23 | +0.14 | hold |
| Legal & General Group Plc | 3,974 | 3,974 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NBC SECURITIES, INC. | 2,000 | 2,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 107,707 | 107,707 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Invesco Ltd. | 19,888 | 19,888 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FEDERATED HERMES, INC. | 950 | 773 | -177 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 20,951 | 20,773 | -178 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 8,700 | 8,200 | -500 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 3,631 | 1,403 | -2,228 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,938 | 4,237 | -2,701 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 133,381 | 128,627 | -4,754 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 7,557 | 0 | -7,557 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 10,951 | 0 | -10,951 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 863,883 | 844,235 | -19,648 | 0.36 | 0.82 | +0.46 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 36,702 | 15,058 | -21,644 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 63,797 | 35,195 | -28,602 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 98,253 | 14,592 | -83,661 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 99,491 | 15,027 | -84,464 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 132,209 | 20,577 | -111,632 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 211,481 | 96,481 | -115,000 | 0.01 | 0.01 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 119,793 | 0 | -119,793 | 0.00 | 0.00 | -0.00 | sell |
| Rubric Capital Management LP | 5,684,420 | 5,564,123 | -120,297 | 0.28 | 0.57 | +0.28 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 910,094 | 740,128 | -169,966 | 0.11 | 0.22 | +0.11 | sell |
| CITADEL ADVISORS LLC | 185,058 | 0 | -185,058 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 300,000 | 0 | -300,000 | 0.04 | 0.00 | -0.04 | sell |
| Anson Funds Management LP | 420,803 | 0 | -420,803 | 0.11 | 0.00 | -0.11 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 542,700 | 116,842 | -425,858 | 0.00 | 0.00 | -0.00 | sell |
| Checkpoint Capital L.P. | 1,292,316 | 506,082 | -786,234 | 1.21 | 1.17 | -0.04 | sell |
| Rosalind Advisors, Inc. | 1,862,425 | 926,016 | -936,409 | 2.09 | 2.99 | +0.90 | sell |
| Tejara Capital Ltd | 1,269,000 | 37,481 | -1,231,519 | 0.71 | 0.05 | -0.66 | sell |