| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Octagon Capital Advisors LP | 0 | 3,322,000 | +3,322,000 | 0.00 | 2.85 | +2.85 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 2,988,000 | +2,988,000 | 0.00 | 0.50 | +0.50 | buy |
| MARSHALL WACE, LLP | 42,921 | 2,554,221 | +2,511,300 | 0.00 | 0.02 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,758,619 | +1,758,619 | 0.00 | 0.03 | +0.03 | buy |
| BlackRock, Inc. | 3,928,462 | 5,312,542 | +1,384,080 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 1,250,000 | +1,250,000 | 0.00 | 1.23 | +1.23 | buy |
| ORBIMED ADVISORS LLC | 0 | 1,120,000 | +1,120,000 | 0.00 | 0.17 | +0.17 | buy |
| Invesco Ltd. | 23,621 | 852,985 | +829,364 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 180,419 | 823,249 | +642,830 | 0.00 | 0.01 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 550,919 | +550,919 | 0.00 | 0.60 | +0.60 | buy |
| RAYMOND JAMES FINANCIAL INC | 12,000 | 509,379 | +497,379 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 494,567 | +494,567 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 340,164 | +340,164 | 0.00 | 0.09 | +0.09 | buy |
| MPM BioImpact LLC | 3,094,896 | 3,428,366 | +333,470 | 1.81 | 3.71 | +1.90 | buy |
| Rubric Capital Management LP | 4,205,129 | 4,538,535 | +333,406 | 0.32 | 0.51 | +0.20 | buy |
| VANGUARD GROUP INC | 3,509,213 | 3,838,032 | +328,819 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,299,322 | 1,614,865 | +315,543 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 281,099 | +281,099 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,170,682 | 1,424,506 | +253,824 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 325,000 | 575,000 | +250,000 | 0.38 | 1.18 | +0.80 | buy |
| PANAGORA ASSET MANAGEMENT INC | 120,304 | 339,904 | +219,600 | 0.00 | 0.01 | +0.01 | buy |
| DIADEMA PARTNERS LP | 0 | 180,000 | +180,000 | 0.00 | 0.90 | +0.90 | buy |
| Exome Asset Management LLC | 0 | 163,738 | +163,738 | 0.00 | 0.92 | +0.92 | buy |
| ACORN CAPITAL ADVISORS, LLC | 2,001,048 | 2,144,844 | +143,796 | 4.44 | 9.00 | +4.56 | buy |
| Jump Financial, LLC | 21,589 | 160,815 | +139,226 | 0.00 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 131,765 | +131,765 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 127,452 | +127,452 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 126,229 | +126,229 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 89,309 | 206,962 | +117,653 | 0.01 | 0.02 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 64,500 | 175,145 | +110,645 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 100,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 0 | 93,033 | +93,033 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 86,760 | +86,760 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 482,815 | 566,197 | +83,382 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 81,800 | +81,800 | 0.00 | 0.40 | +0.40 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 76,699 | +76,699 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 0 | 72,083 | +72,083 | 0.00 | 0.02 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 93,859 | 164,740 | +70,881 | 0.01 | 0.04 | +0.02 | buy |
| Polar Asset Management Partners Inc. | 0 | 64,050 | +64,050 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 14,059 | 74,552 | +60,493 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 49,937 | +49,937 | 0.00 | 0.03 | +0.03 | buy |
| BIT Capital GmbH | 0 | 41,987 | +41,987 | 0.00 | 0.03 | +0.03 | buy |
| Persistent Asset Partners Ltd | 0 | 41,404 | +41,404 | 0.00 | 0.23 | +0.23 | buy |
| WEXFORD CAPITAL LP | 0 | 40,000 | +40,000 | 0.00 | 0.07 | +0.07 | buy |
| FRANKLIN RESOURCES INC | 0 | 37,271 | +37,271 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 173,063 | 207,518 | +34,455 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 0 | 31,359 | +31,359 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 1,356,886 | 1,385,050 | +28,164 | 0.04 | 0.07 | +0.02 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 27,256 | +27,256 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 140,219 | 166,076 | +25,857 | 0.00 | 0.00 | +0.00 | buy |
| Tejara Capital Ltd | 153,739 | 179,516 | +25,777 | 0.42 | 0.56 | +0.14 | buy |
| Atom Investors LP | 0 | 23,996 | +23,996 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 96,784 | 117,962 | +21,178 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 19,098 | +19,098 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 81,403 | 100,437 | +19,034 | 0.01 | 0.01 | +0.00 | buy |
| Creative Planning | 0 | 17,231 | +17,231 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 16,534 | +16,534 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 0 | 15,002 | +15,002 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 771,958 | 785,961 | +14,003 | 3.20 | 5.73 | +2.53 | buy |
| RHUMBLINE ADVISERS | 79,874 | 90,482 | +10,608 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 33,698 | 44,143 | +10,445 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 29,243 | 37,626 | +8,383 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 33,050 | 41,096 | +8,046 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 25,166 | 32,162 | +6,996 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 15,440 | 22,340 | +6,900 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 30,091 | 36,503 | +6,412 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 47,856 | 53,894 | +6,038 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 38,785 | 44,656 | +5,871 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 23,032 | 27,720 | +4,688 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 11,807 | 15,834 | +4,027 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 2,881 | +2,881 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 11,015 | 13,715 | +2,700 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 2 | 2,000 | +1,998 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 78,143 | 79,796 | +1,653 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 4,360 | 6,001 | +1,641 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 16,298 | 17,925 | +1,627 | 0.01 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 1,540 | +1,540 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 1,403 | 2,568 | +1,165 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 1,051 | +1,051 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 23,431 | 24,412 | +981 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 6,542 | 7,462 | +920 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,614 | 1,968 | +354 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,561 | 2,902 | +341 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 305 | +305 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 169 | +169 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 147 | +147 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 140 | +140 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 135 | +135 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 78 | +78 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 36,502 | 36,502 | 0 | 0.02 | 0.03 | +0.01 | hold |
| Ameritas Investment Partners, Inc. | 6,332 | 6,332 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,497 | 4,497 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UNITED BANK | 31,200 | 31,200 | 0 | 0.02 | 0.02 | +0.01 | hold |
| NEA Management Company, LLC | 11,370,376 | 11,370,376 | 0 | 2.76 | 5.51 | +2.75 | hold |
| Vivo Capital, LLC | 3,487,903 | 3,487,903 | 0 | 1.61 | 2.91 | +1.30 | hold |
| Farther Finance Advisors, LLC | 55 | 55 | 0 | 0.00 | 0.00 | +0.00 | hold |