| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 3,094,896 | 3,428,366 | +333,470 | 1.81 | 3.71 | +1.90 | buy |
| Rubric Capital Management LP | 4,205,129 | 4,538,535 | +333,406 | 0.22 | 0.51 | +0.29 | buy |
| Ikarian Capital, LLC | 325,000 | 575,000 | +250,000 | 0.38 | 1.18 | +0.80 | buy |
| ACORN CAPITAL ADVISORS, LLC | 2,001,048 | 2,144,844 | +143,796 | 4.44 | 9.00 | +4.56 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 177,481 | 79,981 | +97,500 | 0.02 | 0.01 | 0.00 | sell |
| MAI Capital Management | 1,356,886 | 1,385,050 | +28,164 | 0.04 | 0.07 | +0.02 | buy |
| Tejara Capital Ltd | 153,739 | 179,516 | +25,777 | 0.42 | 0.56 | +0.14 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 771,958 | 785,961 | +14,003 | 3.20 | 5.73 | +2.53 | buy |
| China Universal Asset Management Co., Ltd. | 16,298 | 17,925 | +1,627 | 0.01 | 0.01 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,614 | 1,968 | +354 | 0.00 | 0.00 | +0.00 | buy |
| WealthTrust Axiom LLC | 65,500 | 63,500 | -2,000 | 0.08 | 0.12 | +0.04 | sell |
| Siren, L.L.C. | 2,906,060 | 2,863,793 | -42,267 | 0.53 | 1.02 | +0.49 | sell |
| Ally Bridge Group (NY) LLC | 781,489 | 686,219 | -95,270 | 2.76 | 3.89 | +1.13 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 734,234 | 530,000 | -204,234 | 0.68 | 0.70 | +0.02 | sell |
| J. Goldman & Co LP | 537,609 | 201,107 | -336,502 | 0.06 | 0.03 | -0.03 | sell |
| Frazier Life Sciences Management, L.P. | 10,664,774 | 10,259,409 | -405,365 | 1.82 | 2.95 | +1.13 | sell |
| Rosalind Advisors, Inc. | 1,062,500 | 612,901 | -449,599 | 2.24 | 1.87 | -0.36 | sell |
| VR Adviser, LLC | 1,266,457 | 615,506 | -650,951 | 0.36 | 0.33 | -0.03 | sell |
| Logos Global Management LP | 1,250,000 | 424,715 | -825,285 | 0.60 | 0.47 | -0.13 | sell |
| Woodline Partners LP | 3,212,597 | 2,057,812 | -1,154,785 | 0.09 | 0.08 | -0.01 | sell |
| VIKING GLOBAL INVESTORS LP | 4,400,000 | 3,227,792 | -1,172,208 | 0.06 | 0.06 | +0.01 | sell |
| Opaleye Management Inc. | 2,317,500 | 795,000 | -1,522,500 | 1.67 | 1.11 | -0.56 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,500,000 | 440,000 | -2,060,000 | 0.02 | 0.01 | -0.01 | sell |