| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 0 | 2,166,504 | +2,166,504 | 0.00 | 0.72 | +0.72 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,403,990 | 5,189,088 | +1,785,098 | 0.01 | 0.01 | +0.00 | buy |
| FMR LLC | 6,500,009 | 8,038,061 | +1,538,052 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 152,855 | 1,201,489 | +1,048,634 | 0.00 | 0.01 | +0.01 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,108,468 | 1,994,292 | +885,824 | 0.15 | 0.24 | +0.10 | buy |
| Logos Global Management LP | 1,550,000 | 2,400,000 | +850,000 | 1.29 | 1.47 | +0.18 | buy |
| Candriam S.C.A. | 0 | 773,620 | +773,620 | 0.00 | 0.05 | +0.05 | buy |
| Soleus Capital Management, L.P. | 900,000 | 1,620,000 | +720,000 | 0.48 | 0.78 | +0.30 | buy |
| Ensign Peak Advisors, Inc | 0 | 464,746 | +464,746 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,412,885 | 2,778,231 | +365,346 | 0.00 | 0.00 | +0.00 | buy |
| GMT CAPITAL CORP | 0 | 317,700 | +317,700 | 0.00 | 0.17 | +0.17 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 174,641 | 473,849 | +299,208 | 0.00 | 0.01 | +0.01 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,256,782 | 1,553,726 | +296,944 | 6.08 | 6.63 | +0.54 | buy |
| STATE STREET CORP | 2,435,000 | 2,665,313 | +230,313 | 0.00 | 0.00 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 917,450 | 1,142,950 | +225,500 | 0.91 | 1.50 | +0.59 | buy |
| Propel Bio Management, LLC | 0 | 223,802 | +223,802 | 0.00 | 1.67 | +1.67 | buy |
| AMERIPRISE FINANCIAL INC | 324,172 | 504,836 | +180,664 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,532,013 | 1,706,048 | +174,035 | 0.02 | 0.02 | +0.00 | buy |
| UBS Group AG | 274,628 | 446,192 | +171,564 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,056,891 | 1,227,772 | +170,881 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 128,325 | +128,325 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,094,851 | 1,216,955 | +122,104 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 10,126,183 | 10,240,186 | +114,003 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 103,967 | +103,967 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 148,292 | 251,566 | +103,274 | 0.99 | 2.14 | +1.15 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 36,502 | 131,502 | +95,000 | 0.05 | 0.15 | +0.10 | buy |
| ExodusPoint Capital Management, LP | 0 | 79,859 | +79,859 | 0.00 | 0.01 | +0.01 | buy |
| Simplify Asset Management Inc. | 0 | 65,412 | +65,412 | 0.00 | 0.01 | +0.01 | buy |
| Checkpoint Capital L.P. | 0 | 50,000 | +50,000 | 0.00 | 0.21 | +0.21 | buy |
| NORTHERN TRUST CORP | 761,966 | 806,659 | +44,693 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 141,312 | 181,344 | +40,032 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 36,464 | +36,464 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 29,133 | +29,133 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 52,960 | 80,883 | +27,923 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 25,930 | +25,930 | 0.00 | 0.01 | +0.01 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 507,685 | 530,451 | +22,766 | 0.19 | 0.23 | +0.04 | buy |
| Brevan Howard Capital Management LP | 0 | 18,895 | +18,895 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 17,034 | +17,034 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 27,937 | 43,561 | +15,624 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 50,273 | 64,703 | +14,430 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 120,566 | 134,731 | +14,165 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 70,833 | 84,755 | +13,922 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 140,733 | 154,168 | +13,435 | 0.00 | 0.00 | +0.00 | buy |
| Harbour Capital Advisors, LLC | 27,500 | 40,700 | +13,200 | 0.07 | 0.11 | +0.05 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 46,681 | 59,862 | +13,181 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 20,895 | 32,755 | +11,860 | 0.02 | 0.03 | +0.01 | buy |
| MPM BioImpact LLC | 3,287,087 | 3,298,430 | +11,343 | 4.71 | 3.04 | -1.67 | buy |
| JPMORGAN CHASE & CO | 59,475 | 70,631 | +11,156 | 0.00 | 0.00 | +0.00 | buy |
| Maltin Wealth Management, Inc. | 0 | 10,560 | +10,560 | 0.00 | 0.05 | +0.05 | buy |
| SIH Partners, LLLP | 0 | 10,001 | +10,001 | 0.00 | 0.00 | +0.00 | buy |
| FLPUTNAM INVESTMENT MANAGEMENT CO | 1,053,427 | 1,063,301 | +9,874 | 0.19 | 0.19 | -0.00 | buy |
| WEXFORD CAPITAL LP | 82,034 | 90,752 | +8,718 | 0.26 | 0.18 | -0.09 | buy |
| Russell Investments Group, Ltd. | 59,444 | 68,120 | +8,676 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 44,095 | 51,525 | +7,430 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 6,660 | +6,660 | 0.00 | 0.02 | +0.02 | buy |
| Creative Planning | 40,222 | 45,865 | +5,643 | 0.00 | 0.00 | +0.00 | buy |
| Kingsview Wealth Management, LLC | 10,638 | 15,770 | +5,132 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 56,269 | 61,298 | +5,029 | 0.01 | 0.02 | +0.00 | buy |
| Nuveen, LLC | 183,329 | 188,182 | +4,853 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 4,300 | +4,300 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 836,800 | 840,572 | +3,772 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 105,922 | 109,061 | +3,139 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,063 | 44,853 | +2,790 | 0.00 | 0.00 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 899 | 3,506 | +2,607 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 20,984 | 23,477 | +2,493 | 0.00 | 0.01 | +0.00 | buy |
| KBC Group NV | 0 | 2,464 | +2,464 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 1,784 | +1,784 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 19,378 | 21,114 | +1,736 | 0.01 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 50,250 | 51,814 | +1,564 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 9 | 1,047 | +1,038 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 22,056 | 23,025 | +969 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 570,226 | 570,971 | +745 | 0.01 | 0.01 | -0.00 | buy |
| Woodline Partners LP | 1,000,282 | 1,000,782 | +500 | 0.05 | 0.05 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 87 | 555 | +468 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 6,231 | 6,688 | +457 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 620 | 1,007 | +387 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,519 | 2,865 | +346 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 378 | 666 | +288 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 232 | +232 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 4 | 85 | +81 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 70 | +70 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 381 | 424 | +43 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 581 | 621 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Bare Financial Services, Inc | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| TWIN PEAKS WEALTH ADVISORS, LLC | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 753 | 767 | +14 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 0 | 12 | +12 | 0.00 | 0.00 | 0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| Hughes Financial Services, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Stone House Investment Management, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 7,632 | 7,632 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 516 | 516 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 3,198,644 | 3,198,644 | 0 | 0.11 | 0.11 | +0.00 | hold |
| JANUS HENDERSON GROUP PLC | 37,127 | 37,127 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UNITED BANK | 31,200 | 31,200 | 0 | 0.05 | 0.05 | -0.00 | hold |
| WealthTrust Axiom LLC | 61,500 | 61,500 | 0 | 0.20 | 0.18 | -0.02 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,622,306 | 2,622,306 | 0 | 0.51 | 0.52 | +0.00 | hold |
| Parkside Financial Bank & Trust | 140 | 140 | 0 | 0.00 | 0.00 | -0.00 | hold |