| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 13,222,228 | 13,222,228 | 0 | 8.44 | 8.97 | +0.53 | hold |
| BlackRock, Inc. | 10,126,183 | 10,240,186 | +114,003 | 0.00 | 0.00 | -0.00 | buy |
| Frazier Life Sciences Management, L.P. | 10,259,409 | 9,939,547 | -319,862 | 3.45 | 3.05 | -0.40 | sell |
| FMR LLC | 6,500,009 | 8,038,061 | +1,538,052 | 0.00 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,403,990 | 5,189,088 | +1,785,098 | 0.01 | 0.01 | +0.00 | buy |
| Vivo Capital, LLC | 5,094,668 | 5,094,668 | 0 | 4.12 | 5.05 | +0.93 | hold |
| MARSHALL WACE, LLP | 4,580,548 | 3,966,019 | -614,529 | 0.06 | 0.05 | -0.00 | sell |
| Rubric Capital Management LP | 3,766,749 | 3,712,373 | -54,376 | 0.56 | 0.54 | -0.02 | sell |
| MPM BioImpact LLC | 3,287,087 | 3,298,430 | +11,343 | 4.71 | 3.04 | -1.67 | buy |
| VIKING GLOBAL INVESTORS LP | 3,198,644 | 3,198,644 | 0 | 0.11 | 0.11 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 3,082,986 | 2,845,472 | -237,514 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,412,885 | 2,778,231 | +365,346 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 2,435,000 | 2,665,313 | +230,313 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,622,306 | 2,622,306 | 0 | 0.51 | 0.52 | +0.00 | hold |
| ORBIMED ADVISORS LLC | 3,190,700 | 2,454,400 | -736,300 | 0.82 | 0.64 | -0.18 | sell |
| Logos Global Management LP | 1,550,000 | 2,400,000 | +850,000 | 1.29 | 1.47 | +0.18 | buy |
| Vestal Point Capital, LP | 0 | 2,166,504 | +2,166,504 | 0.00 | 0.72 | +0.72 | buy |
| ACORN CAPITAL ADVISORS, LLC | 2,144,844 | 2,144,844 | 0 | 9.10 | 7.27 | -1.83 | hold |
| Artia Global Partners LP | 2,013,602 | 2,013,602 | 0 | 4.05 | 5.42 | +1.37 | hold |
| Affinity Asset Advisors, LLC | 2,150,172 | 2,000,172 | -150,000 | 1.93 | 1.40 | -0.53 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,108,468 | 1,994,292 | +885,824 | 0.15 | 0.24 | +0.10 | buy |
| EMERALD ADVISERS, LLC | 1,892,276 | 1,839,566 | -52,710 | 0.73 | 0.69 | -0.04 | sell |
| Siren, L.L.C. | 2,286,867 | 1,786,867 | -500,000 | 0.85 | 0.59 | -0.26 | sell |
| Pictet Asset Management Holding SA | 1,532,013 | 1,706,048 | +174,035 | 0.02 | 0.02 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 1,766,963 | 1,687,977 | -78,986 | 0.01 | 0.01 | -0.00 | sell |
| Soleus Capital Management, L.P. | 900,000 | 1,620,000 | +720,000 | 0.48 | 0.78 | +0.30 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,256,782 | 1,553,726 | +296,944 | 6.08 | 6.63 | +0.54 | buy |
| Octagon Capital Advisors LP | 2,815,000 | 1,485,000 | -1,330,000 | 4.41 | 1.96 | -2.45 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,272,373 | 1,262,492 | -9,881 | 0.78 | 0.73 | -0.05 | sell |
| GOLDMAN SACHS GROUP INC | 1,056,891 | 1,227,772 | +170,881 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,094,851 | 1,216,955 | +122,104 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 152,855 | 1,201,489 | +1,048,634 | 0.00 | 0.01 | +0.01 | buy |
| NAN FUNG TRINITY (HK) Ltd | 917,450 | 1,142,950 | +225,500 | 0.91 | 1.50 | +0.59 | buy |
| FLPUTNAM INVESTMENT MANAGEMENT CO | 1,053,427 | 1,063,301 | +9,874 | 0.19 | 0.19 | -0.00 | buy |
| Woodline Partners LP | 1,000,282 | 1,000,782 | +500 | 0.05 | 0.05 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 836,800 | 840,572 | +3,772 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 761,966 | 806,659 | +44,693 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 0 | 773,620 | +773,620 | 0.00 | 0.05 | +0.05 | buy |
| MORGAN STANLEY | 1,050,296 | 731,255 | -319,041 | 0.00 | 0.00 | -0.00 | sell |
| PANAGORA ASSET MANAGEMENT INC | 693,001 | 625,578 | -67,423 | 0.03 | 0.03 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 598,534 | 574,029 | -24,505 | 1.57 | 1.18 | -0.39 | sell |
| MILLENNIUM MANAGEMENT LLC | 570,226 | 570,971 | +745 | 0.01 | 0.01 | -0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 507,685 | 530,451 | +22,766 | 0.19 | 0.23 | +0.04 | buy |
| Burkehill Global Management, LP | 525,000 | 525,000 | 0 | 0.43 | 0.31 | -0.12 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 541,240 | 511,127 | -30,113 | 0.98 | 0.72 | -0.26 | sell |
| AMERIPRISE FINANCIAL INC | 324,172 | 504,836 | +180,664 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 174,641 | 473,849 | +299,208 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 0 | 464,746 | +464,746 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 274,628 | 446,192 | +171,564 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 498,926 | 352,984 | -145,942 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 345,100 | 345,100 | 0 | 0.57 | 0.54 | -0.03 | hold |
| GMT CAPITAL CORP | 0 | 317,700 | +317,700 | 0.00 | 0.17 | +0.17 | buy |
| Bank of New York Mellon Corp | 260,587 | 260,161 | -426 | 0.00 | 0.00 | -0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 148,292 | 251,566 | +103,274 | 0.99 | 2.14 | +1.15 | buy |
| J. Goldman & Co LP | 444,357 | 236,959 | -207,398 | 0.22 | 0.13 | -0.09 | sell |
| F/m Investments LLC | 241,483 | 231,602 | -9,881 | 0.11 | 0.18 | +0.07 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 825,548 | 227,688 | -597,860 | 0.01 | 0.00 | -0.01 | sell |
| Propel Bio Management, LLC | 0 | 223,802 | +223,802 | 0.00 | 1.67 | +1.67 | buy |
| Nuveen, LLC | 183,329 | 188,182 | +4,853 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 141,312 | 181,344 | +40,032 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 168,200 | 168,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 140,733 | 154,168 | +13,435 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 120,566 | 134,731 | +14,165 | 0.00 | 0.00 | +0.00 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 36,502 | 131,502 | +95,000 | 0.05 | 0.15 | +0.10 | buy |
| FIFTH THIRD BANCORP | 0 | 128,325 | +128,325 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 105,922 | 109,061 | +3,139 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 103,967 | +103,967 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 100,698 | 100,027 | -671 | 0.02 | 0.01 | -0.00 | sell |
| LMR Partners LLP | 100,000 | 100,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CITIGROUP INC | 123,498 | 99,949 | -23,549 | 0.00 | 0.00 | -0.00 | sell |
| WEXFORD CAPITAL LP | 82,034 | 90,752 | +8,718 | 0.26 | 0.18 | -0.09 | buy |
| Erste Asset Management GmbH | 90,000 | 90,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 70,833 | 84,755 | +13,922 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 83,788 | 83,391 | -397 | 0.00 | 0.00 | +0.00 | sell |
| LPL Financial LLC | 52,960 | 80,883 | +27,923 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 79,859 | +79,859 | 0.00 | 0.01 | +0.01 | buy |
| PFS Partners, LLC | 79,000 | 79,000 | 0 | 0.45 | 0.43 | -0.02 | hold |
| SEI INVESTMENTS CO | 147,941 | 78,222 | -69,719 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 84,255 | 74,446 | -9,809 | 0.85 | 0.78 | -0.07 | sell |
| JPMORGAN CHASE & CO | 59,475 | 70,631 | +11,156 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 59,444 | 68,120 | +8,676 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 0 | 65,412 | +65,412 | 0.00 | 0.01 | +0.01 | buy |
| MAI Capital Management | 77,769 | 65,125 | -12,644 | 0.01 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 50,273 | 64,703 | +14,430 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 68,481 | 64,524 | -3,957 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 81,673 | 63,819 | -17,854 | 0.00 | 0.00 | -0.00 | sell |
| WealthTrust Axiom LLC | 61,500 | 61,500 | 0 | 0.20 | 0.18 | -0.02 | hold |
| KENNEDY CAPITAL MANAGEMENT LLC | 56,269 | 61,298 | +5,029 | 0.01 | 0.02 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 46,681 | 59,862 | +13,181 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 582,653 | 53,585 | -529,068 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 106,159 | 53,525 | -52,634 | 0.34 | 0.18 | -0.17 | sell |
| MetLife Investment Management, LLC | 50,250 | 51,814 | +1,564 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 44,095 | 51,525 | +7,430 | 0.00 | 0.00 | +0.00 | buy |
| Checkpoint Capital L.P. | 0 | 50,000 | +50,000 | 0.00 | 0.21 | +0.21 | buy |
| FRANKLIN RESOURCES INC | 49,878 | 49,878 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Creative Planning | 40,222 | 45,865 | +5,643 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 130,000 | 45,000 | -85,000 | 0.07 | 0.03 | -0.04 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 42,063 | 44,853 | +2,790 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 226,215 | 44,357 | -181,858 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 27,937 | 43,561 | +15,624 | 0.00 | 0.00 | +0.00 | buy |