| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Ally Bridge Group (NY) LLC | 0 | 1,474,926 | +1,474,926 | 0.00 | 2.62 | +2.62 | buy |
| Logos Global Management LP | 2,200,000 | 2,800,000 | +600,000 | 0.80 | 0.96 | +0.16 | buy |
| Rosalind Advisors, Inc. | 926,016 | 1,391,577 | +465,561 | 2.99 | 3.28 | +0.29 | buy |
| Tejara Capital Ltd | 37,481 | 405,988 | +368,507 | 0.05 | 0.44 | +0.39 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 260,000 | +260,000 | 0.00 | 0.65 | +0.65 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 897,965 | 1,146,748 | +248,783 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 1,340,960 | 1,510,174 | +169,214 | 0.74 | 0.70 | -0.04 | buy |
| VANGUARD GROUP INC | 2,303,648 | 2,437,451 | +133,803 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 798,249 | 899,861 | +101,612 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 96,481 | 185,481 | +89,000 | 0.01 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 128,627 | 178,511 | +49,884 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 22,735 | 72,210 | +49,475 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 107,707 | 150,918 | +43,211 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 37,974 | 73,193 | +35,219 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 51,955 | 75,218 | +23,263 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 19,612 | +19,612 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 15,440 | +15,440 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,074 | 24,524 | +11,450 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 137,873 | 148,917 | +11,044 | 0.02 | 0.02 | -0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,274 | 22,434 | +9,160 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 46,206 | 54,108 | +7,902 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 7,061 | +7,061 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 16,839 | 23,478 | +6,639 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 13,561 | 19,047 | +5,486 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 8,703 | 12,987 | +4,284 | 0.00 | 0.00 | +0.00 | buy |
| UNITED BANK | 28,450 | 31,200 | +2,750 | 0.01 | 0.01 | -0.00 | buy |
| Legal & General Group Plc | 3,974 | 6,542 | +2,568 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 10,103 | 12,303 | +2,200 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 60,415 | 60,819 | +404 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,058 | 15,265 | +207 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 3,535 | 3,604 | +69 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 3 | 33 | +30 | 0.00 | 0.00 | 0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,237 | 4,255 | +18 | 0.00 | 0.00 | -0.00 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 36,502 | 36,502 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Ameritas Investment Partners, Inc. | 3,438 | 3,438 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FEDERATED HERMES, INC. | 773 | 773 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 4,400,000 | 4,400,000 | 0 | 0.06 | 0.05 | -0.01 | hold |
| LPL Financial LLC | 36,000 | 36,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WealthTrust Axiom LLC | 63,500 | 63,500 | 0 | 0.07 | 0.06 | -0.01 | hold |
| NEA Management Company, LLC | 11,370,376 | 11,370,376 | 0 | 2.44 | 2.55 | +0.11 | hold |
| Opaleye Management Inc. | 2,645,000 | 2,645,000 | 0 | 1.99 | 1.80 | -0.19 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 844,235 | 844,235 | 0 | 0.82 | 0.62 | -0.20 | hold |
| Simplify Asset Management Inc. | 200,000 | 200,000 | 0 | 0.07 | 0.05 | -0.01 | hold |
| Frazier Life Sciences Management, L.P. | 7,381,090 | 7,381,090 | 0 | 1.07 | 1.03 | -0.05 | hold |
| Propel Bio Management, LLC | 260,000 | 260,000 | 0 | 0.52 | 0.50 | -0.02 | hold |
| Farther Finance Advisors, LLC | 55 | 55 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAILARD, INC. | 40,900 | 40,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NBC SECURITIES, INC. | 2,000 | 2,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 8,200 | 8,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 1,403 | 1,403 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 6 | 0 | -6 | 0.00 | 0.00 | -0.00 | sell |
| Steward Partners Investment Advisory, LLC | 25 | 0 | -25 | 0.00 | 0.00 | -0.00 | sell |
| VR Adviser, LLC | 3,422,675 | 3,422,637 | -38 | 0.56 | 0.65 | +0.09 | sell |
| Invesco Ltd. | 19,888 | 19,723 | -165 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 35,195 | 33,915 | -1,280 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,335 | 0 | -2,335 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 22,693 | 18,881 | -3,812 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 17,817 | 13,923 | -3,894 | 0.00 | 0.00 | -0.00 | sell |
| Checkpoint Capital L.P. | 506,082 | 500,089 | -5,993 | 1.17 | 0.90 | -0.27 | sell |
| NORTHERN TRUST CORP | 327,692 | 321,102 | -6,590 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 21,608 | 14,948 | -6,660 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 14,592 | 0 | -14,592 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 15,027 | 0 | -15,027 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 20,577 | 5,166 | -15,411 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 18,441 | 0 | -18,441 | 0.00 | 0.00 | -0.00 | sell |
| PFS Partners, LLC | 99,000 | 79,000 | -20,000 | 0.23 | 0.15 | -0.08 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 20,773 | 0 | -20,773 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 113,662 | 88,462 | -25,200 | 0.11 | 0.07 | -0.04 | sell |
| UBS Group AG | 42,118 | 0 | -42,118 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 45,736 | 0 | -45,736 | 0.02 | 0.00 | -0.02 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 116,842 | 51,900 | -64,942 | 0.00 | 0.00 | -0.00 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 740,128 | 605,442 | -134,686 | 0.22 | 0.15 | -0.07 | sell |
| Rubric Capital Management LP | 5,564,123 | 5,026,931 | -537,192 | 0.57 | 0.40 | -0.17 | sell |