| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Rubric Capital Management LP | 4,538,535 | 8,531,860 | +3,993,325 | 0.51 | 0.70 | +0.19 | buy |
| ORBIMED ADVISORS LLC | 1,120,000 | 3,308,400 | +2,188,400 | 0.17 | 0.46 | +0.29 | buy |
| Woodline Partners LP | 2,057,812 | 4,046,435 | +1,988,623 | 0.08 | 0.12 | +0.03 | buy |
| NEA Management Company, LLC | 11,370,376 | 13,222,228 | +1,851,852 | 5.51 | 5.44 | -0.06 | buy |
| Affinity Asset Advisors, LLC | 1,250,000 | 2,534,058 | +1,284,058 | 0.75 | 1.89 | +1.14 | buy |
| Siren, L.L.C. | 2,863,793 | 3,938,793 | +1,075,000 | 1.02 | 1.11 | +0.10 | buy |
| Vivo Capital, LLC | 3,487,903 | 4,487,903 | +1,000,000 | 2.91 | 2.51 | -0.39 | buy |
| J. Goldman & Co LP | 201,107 | 979,098 | +777,991 | 0.03 | 0.13 | +0.10 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,758,619 | 2,354,402 | +595,783 | 0.03 | 0.03 | 0.00 | buy |
| MAI Capital Management | 1,385,050 | 847,553 | +537,497 | 0.07 | 0.03 | -0.03 | sell |
| Logos Global Management LP | 424,715 | 850,000 | +425,285 | 0.47 | 0.51 | +0.04 | buy |
| Octagon Capital Advisors LP | 3,322,000 | 3,672,000 | +350,000 | 4.11 | 4.41 | +0.30 | buy |
| Tejara Capital Ltd | 179,516 | 326,395 | +146,879 | 0.56 | 0.83 | +0.27 | buy |
| SECTORAL ASSET MANAGEMENT INC | 81,800 | 134,150 | +52,350 | 0.40 | 0.48 | +0.08 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 79,981 | 44,981 | +35,000 | 0.01 | 0.01 | 0.00 | sell |
| Polar Asset Management Partners Inc. | 64,050 | 74,300 | +10,250 | 0.01 | 0.01 | -0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 530,000 | 539,587 | +9,587 | 0.70 | 0.60 | -0.09 | buy |
| DIADEMA PARTNERS LP | 180,000 | 185,830 | +5,830 | 0.90 | 0.63 | -0.27 | buy |
| Diversified Trust Co | 15,002 | 18,309 | +3,307 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 17,925 | 20,435 | +2,510 | 0.01 | 0.01 | +0.00 | buy |
| Persistent Asset Partners Ltd | 41,404 | 42,788 | +1,384 | 0.23 | 0.21 | -0.02 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 27,256 | 27,851 | +595 | 0.00 | 0.00 | -0.00 | buy |
| WealthTrust Axiom LLC | 63,500 | 61,500 | -2,000 | 0.12 | 0.10 | -0.02 | sell |
| FRED ALGER MANAGEMENT, LLC | 76,699 | 59,425 | -17,274 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 3,428,366 | 3,406,955 | -21,411 | 3.71 | 3.23 | -0.48 | sell |
| BIT Capital GmbH | 41,987 | 5,106 | -36,881 | 0.02 | 0.00 | -0.02 | sell |
| Quadrature Capital Ltd | 86,760 | 25,848 | -60,912 | 0.01 | 0.00 | -0.01 | sell |
| Informed Momentum Co LLC | 550,919 | 486,624 | -64,295 | 0.60 | 0.40 | -0.20 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 785,961 | 493,735 | -292,226 | 5.73 | 3.77 | -1.96 | sell |
| Rosalind Advisors, Inc. | 612,901 | 300,000 | -312,901 | 1.87 | 0.78 | -1.10 | sell |
| Opaleye Management Inc. | 795,000 | 390,000 | -405,000 | 1.11 | 0.43 | -0.68 | sell |
| VIKING GLOBAL INVESTORS LP | 3,227,792 | 1,543,000 | -1,684,792 | 0.06 | 0.02 | -0.04 | sell |