| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ALLIANCEBERNSTEIN L.P. | 22,340 | 4,281,355 | +4,259,015 | 0.00 | 0.01 | +0.01 | buy |
| Rubric Capital Management LP | 4,538,535 | 8,531,860 | +3,993,325 | 0.51 | 0.75 | +0.24 | buy |
| BlackRock, Inc. | 5,312,542 | 8,205,006 | +2,892,464 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,120,000 | 3,308,400 | +2,188,400 | 0.17 | 0.46 | +0.29 | buy |
| Woodline Partners LP | 2,057,812 | 4,046,435 | +1,988,623 | 0.08 | 0.12 | +0.03 | buy |
| NEA Management Company, LLC | 11,370,376 | 13,222,228 | +1,851,852 | 5.51 | 5.44 | -0.06 | buy |
| VANGUARD GROUP INC | 3,838,032 | 5,316,691 | +1,478,659 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 1,381,324 | +1,381,324 | 0.00 | 0.13 | +0.13 | buy |
| CITADEL ADVISORS LLC | 0 | 1,319,266 | +1,319,266 | 0.00 | 0.01 | +0.01 | buy |
| Artia Global Partners LP | 0 | 1,311,840 | +1,311,840 | 0.00 | 1.85 | +1.85 | buy |
| Affinity Asset Advisors, LLC | 1,250,000 | 2,534,058 | +1,284,058 | 1.23 | 2.05 | +0.82 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 0 | 1,146,110 | +1,146,110 | 0.00 | 3.89 | +3.89 | buy |
| Siren, L.L.C. | 2,863,793 | 3,938,793 | +1,075,000 | 1.02 | 1.11 | +0.10 | buy |
| Vivo Capital, LLC | 3,487,903 | 4,487,903 | +1,000,000 | 2.91 | 2.51 | -0.39 | buy |
| BANK OF AMERICA CORP /DE/ | 131,765 | 1,097,497 | +965,732 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 19,098 | 824,180 | +805,082 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 799,957 | +799,957 | 0.00 | 1.14 | +1.14 | buy |
| J. Goldman & Co LP | 201,107 | 979,098 | +777,991 | 0.04 | 0.17 | +0.12 | buy |
| Soleus Capital Management, L.P. | 0 | 700,000 | +700,000 | 0.00 | 0.26 | +0.26 | buy |
| Alyeska Investment Group, L.P. | 0 | 650,000 | +650,000 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,758,619 | 2,354,402 | +595,783 | 0.03 | 0.03 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 509,379 | 1,076,683 | +567,304 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 494,567 | 1,024,011 | +529,444 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 525,000 | +525,000 | 0.00 | 0.21 | +0.21 | buy |
| Logos Global Management LP | 424,715 | 850,000 | +425,285 | 0.47 | 0.62 | +0.15 | buy |
| STATE STREET CORP | 1,424,506 | 1,832,920 | +408,414 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 88,900 | 489,300 | +400,400 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 137,932 | 515,476 | +377,544 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 6,001 | 368,529 | +362,528 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 3,322,000 | 3,672,000 | +350,000 | 2.85 | 4.41 | +1.55 | buy |
| Qube Research & Technologies Ltd | 126,229 | 447,852 | +321,623 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 93,033 | 354,225 | +261,192 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 339,904 | 569,702 | +229,798 | 0.01 | 0.01 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 226,381 | +226,381 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,614,865 | 1,786,845 | +171,980 | 0.00 | 0.00 | -0.00 | buy |
| Tejara Capital Ltd | 179,516 | 326,395 | +146,879 | 0.56 | 0.83 | +0.27 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 100,001 | +100,001 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 211,873 | 299,045 | +87,172 | 0.00 | 0.00 | +0.00 | buy |
| FLPUTNAM INVESTMENT MANAGEMENT CO | 0 | 86,952 | +86,952 | 0.00 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 86,830 | +86,830 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 0 | 64,294 | +64,294 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 54,957 | +54,957 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 10,380 | 64,589 | +54,209 | 0.00 | 0.01 | +0.01 | buy |
| SECTORAL ASSET MANAGEMENT INC | 81,800 | 134,150 | +52,350 | 0.40 | 0.48 | +0.08 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 127,452 | 171,982 | +44,530 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 41,495 | +41,495 | 0.00 | 0.07 | +0.07 | buy |
| Graham Capital Management, L.P. | 0 | 40,061 | +40,061 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 117,962 | 154,854 | +36,892 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 35,000 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 27,748 | 62,439 | +34,691 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 33,962 | +33,962 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.03 | +0.03 | buy |
| Dauntless Investment Group, LLC | 0 | 29,000 | +29,000 | 0.00 | 0.75 | +0.75 | buy |
| Engineers Gate Manager LP | 0 | 28,162 | +28,162 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,570 | 30,996 | +25,426 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 22,015 | 43,009 | +20,994 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 207,518 | 225,935 | +18,417 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 18,059 | +18,059 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 16,379 | +16,379 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 90,482 | 106,402 | +15,920 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 8,200 | 24,000 | +15,800 | 0.00 | 0.00 | +0.00 | buy |
| KINGSWOOD WEALTH ADVISORS, LLC | 0 | 14,632 | +14,632 | 0.00 | 0.01 | +0.01 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 13,748 | +13,748 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 37,271 | 49,918 | +12,647 | 0.00 | 0.00 | +0.00 | buy |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC | 0 | 12,644 | +12,644 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 10,983 | +10,983 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 10,300 | +10,300 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 566,197 | 576,471 | +10,274 | 0.00 | 0.00 | -0.00 | buy |
| Polar Asset Management Partners Inc. | 64,050 | 74,300 | +10,250 | 0.01 | 0.01 | -0.00 | buy |
| CITIGROUP INC | 53,894 | 63,959 | +10,065 | 0.00 | 0.00 | -0.00 | buy |
| Longaeva Partners L.P. | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 530,000 | 539,587 | +9,587 | 0.70 | 0.60 | -0.09 | buy |
| Farther Finance Advisors, LLC | 55 | 8,838 | +8,783 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 13,715 | 20,651 | +6,936 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 32,162 | 38,552 | +6,390 | 0.00 | 0.00 | -0.00 | buy |
| DIADEMA PARTNERS LP | 180,000 | 185,830 | +5,830 | 0.90 | 0.63 | -0.27 | buy |
| DEUTSCHE BANK AG\ | 37,626 | 43,437 | +5,811 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,314 | 7,198 | +4,884 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,412 | 28,319 | +3,907 | 0.00 | 0.00 | -0.00 | buy |
| Diversified Trust Co | 15,002 | 18,309 | +3,307 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 17,231 | 20,247 | +3,016 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 1,540 | 4,536 | +2,996 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 17,925 | 20,435 | +2,510 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 117,736 | 120,240 | +2,504 | 0.00 | 0.00 | -0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 2,501 | +2,501 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 10,000 | 12,000 | +2,000 | 0.00 | 0.00 | -0.00 | buy |
| Chung Wu Investment Group, LLC | 0 | 2,000 | +2,000 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 19,830 | 21,545 | +1,715 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 1,689 | +1,689 | 0.00 | 0.01 | +0.01 | buy |
| Persistent Asset Partners Ltd | 41,404 | 42,788 | +1,384 | 0.23 | 0.21 | -0.02 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 1,094 | +1,094 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,902 | 3,930 | +1,028 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 7,462 | 8,446 | +984 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 0 | 635 | +635 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 27,256 | 27,851 | +595 | 0.00 | 0.00 | -0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 528 | +528 | 0.00 | 0.00 | +0.00 | buy |
| First Horizon Advisors, Inc. | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 461 | +461 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 166,076 | 166,265 | +189 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 135 | 229 | +94 | 0.00 | 0.00 | -0.00 | buy |