| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 13,222,228 | 13,222,228 | 0 | 8.97 | 15.53 | +6.56 | hold |
| FMR LLC | 8,038,061 | 12,562,839 | +4,524,778 | 0.01 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 10,240,186 | 11,155,026 | +914,840 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 9,939,547 | 9,939,447 | -100 | 3.05 | 4.04 | +0.99 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 5,189,088 | 5,684,592 | +495,504 | 0.01 | 0.02 | +0.01 | buy |
| Vivo Capital, LLC | 5,094,668 | 5,094,668 | 0 | 5.05 | 8.68 | +3.62 | hold |
| Woodline Partners LP | 1,000,782 | 4,081,333 | +3,080,551 | 0.05 | 0.24 | +0.19 | buy |
| Vestal Point Capital, LP | 2,166,504 | 3,100,000 | +933,496 | 0.72 | 1.35 | +0.63 | buy |
| MPM BioImpact LLC | 3,298,430 | 3,073,577 | -224,853 | 3.04 | 3.50 | +0.46 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,994,292 | 3,070,740 | +1,076,448 | 0.24 | 0.53 | +0.29 | buy |
| STATE STREET CORP | 2,665,313 | 3,027,315 | +362,002 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,778,231 | 2,928,068 | +149,837 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 3,966,019 | 2,674,137 | -1,291,882 | 0.05 | 0.04 | -0.01 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,622,306 | 2,660,000 | +37,694 | 0.52 | 0.66 | +0.15 | buy |
| Rubric Capital Management LP | 3,712,373 | 2,504,513 | -1,207,860 | 0.54 | 0.43 | -0.11 | sell |
| ALLIANCEBERNSTEIN L.P. | 2,845,472 | 2,355,453 | -490,019 | 0.01 | 0.01 | -0.00 | sell |
| Artia Global Partners LP | 2,013,602 | 2,210,852 | +197,250 | 5.42 | 7.84 | +2.42 | buy |
| ACORN CAPITAL ADVISORS, LLC | 2,144,844 | 2,144,844 | 0 | 7.27 | 10.92 | +3.64 | hold |
| First Light Asset Management, LLC | 0 | 2,097,215 | +2,097,215 | 0.00 | 2.38 | +2.38 | buy |
| Pictet Asset Management Holding SA | 1,706,048 | 2,013,786 | +307,738 | 0.02 | 0.04 | +0.01 | buy |
| Logos Global Management LP | 2,400,000 | 1,880,000 | -520,000 | 1.47 | 1.51 | +0.04 | sell |
| Affinity Asset Advisors, LLC | 2,000,172 | 1,800,172 | -200,000 | 1.40 | 1.64 | +0.24 | sell |
| EMERALD ADVISERS, LLC | 1,839,566 | 1,797,611 | -41,955 | 0.69 | 0.79 | +0.09 | sell |
| Siren, L.L.C. | 1,786,867 | 1,786,867 | 0 | 0.59 | 0.68 | +0.09 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,553,726 | 1,742,672 | +188,946 | 6.63 | 10.56 | +3.93 | buy |
| RAYMOND JAMES FINANCIAL INC | 1,687,977 | 1,610,657 | -77,320 | 0.01 | 0.01 | +0.00 | sell |
| VIKING GLOBAL INVESTORS LP | 3,198,644 | 1,544,644 | -1,654,000 | 0.11 | 0.08 | -0.02 | sell |
| BANK OF AMERICA CORP /DE/ | 1,216,955 | 1,532,889 | +315,934 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 0 | 1,525,314 | +1,525,314 | 0.00 | 0.04 | +0.04 | buy |
| ORBIMED ADVISORS LLC | 2,454,400 | 1,430,293 | -1,024,107 | 0.64 | 0.51 | -0.13 | sell |
| NAN FUNG TRINITY (HK) Ltd | 1,142,950 | 1,213,620 | +70,670 | 1.50 | 2.23 | +0.74 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,262,492 | 1,210,965 | -51,527 | 0.73 | 0.79 | +0.06 | sell |
| GOLDMAN SACHS GROUP INC | 1,227,772 | 1,202,520 | -25,252 | 0.00 | 0.00 | +0.00 | sell |
| Soleus Capital Management, L.P. | 1,620,000 | 1,179,618 | -440,382 | 0.78 | 0.76 | -0.02 | sell |
| BARCLAYS PLC | 53,585 | 1,142,077 | +1,088,492 | 0.00 | 0.01 | +0.01 | buy |
| Saturn V Capital Management LP | 0 | 1,052,043 | +1,052,043 | 0.00 | 2.81 | +2.81 | buy |
| FLPUTNAM INVESTMENT MANAGEMENT CO | 1,063,301 | 1,038,057 | -25,244 | 0.19 | 0.23 | +0.04 | sell |
| NORTHERN TRUST CORP | 806,659 | 1,006,038 | +199,379 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 773,620 | 966,219 | +192,599 | 0.05 | 0.08 | +0.03 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 965,402 | +965,402 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 840,572 | 965,402 | +124,830 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 473,849 | 845,087 | +371,238 | 0.01 | 0.03 | +0.02 | buy |
| MORGAN STANLEY | 731,255 | 800,465 | +69,210 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 188,182 | 765,176 | +576,994 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 525,000 | 725,000 | +200,000 | 0.31 | 0.49 | +0.18 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 511,127 | 678,095 | +166,968 | 0.72 | 1.41 | +0.69 | buy |
| AMERIPRISE FINANCIAL INC | 504,836 | 622,381 | +117,545 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 251,566 | 524,224 | +272,658 | 2.14 | 6.17 | +4.03 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 574,029 | 499,029 | -75,000 | 1.18 | 1.33 | +0.15 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 530,451 | 444,310 | -86,141 | 0.23 | 0.27 | +0.03 | sell |
| Ensign Peak Advisors, Inc | 464,746 | 396,173 | -68,573 | 0.01 | 0.01 | +0.00 | sell |
| Octagon Capital Advisors LP | 1,485,000 | 315,000 | -1,170,000 | 1.96 | 0.54 | -1.42 | sell |
| Invesco Ltd. | 352,984 | 311,749 | -41,235 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 345,100 | 310,000 | -35,100 | 0.54 | 0.52 | -0.02 | sell |
| Bank of New York Mellon Corp | 260,161 | 306,681 | +46,520 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 181,344 | 281,996 | +100,652 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 446,192 | 270,498 | -175,694 | 0.00 | 0.00 | -0.00 | sell |
| Informed Momentum Co LLC | 0 | 264,631 | +264,631 | 0.00 | 0.44 | +0.44 | buy |
| FIFTH THIRD BANCORP | 128,325 | 260,644 | +132,319 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 0 | 260,000 | +260,000 | 0.00 | 0.24 | +0.24 | buy |
| Trexquant Investment LP | 0 | 242,537 | +242,537 | 0.00 | 0.03 | +0.03 | buy |
| Walleye Capital LLC | 0 | 241,987 | +241,987 | 0.00 | 0.02 | +0.02 | buy |
| F/m Investments LLC | 231,602 | 234,208 | +2,606 | 0.18 | 0.22 | +0.04 | buy |
| Integral Health Asset Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.15 | +0.15 | buy |
| Swiss National Bank | 168,200 | 192,300 | +24,100 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 154,168 | 183,225 | +29,057 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 625,578 | 182,235 | -443,343 | 0.03 | 0.01 | -0.02 | sell |
| SEVEN GRAND MANAGERS, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.11 | +0.11 | buy |
| RHUMBLINE ADVISERS | 109,061 | 132,463 | +23,402 | 0.00 | 0.00 | +0.00 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 131,502 | 124,002 | -7,500 | 0.15 | 0.19 | +0.04 | sell |
| Harvest Investment Services, LLC | 0 | 115,104 | +115,104 | 0.00 | 0.33 | +0.33 | buy |
| WELLS FARGO & COMPANY/MN | 38,056 | 114,707 | +76,651 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 84,755 | 114,487 | +29,732 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 83,391 | 108,004 | +24,613 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 106,852 | +106,852 | 0.00 | 0.06 | +0.06 | buy |
| Qube Research & Technologies Ltd | 0 | 102,226 | +102,226 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 100,000 | 100,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| OPPENHEIMER & CO INC | 100,027 | 99,771 | -256 | 0.01 | 0.02 | +0.01 | sell |
| SIMPLEX TRADING, LLC | 20,277 | 97,557 | +77,280 | 0.01 | 0.05 | +0.04 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 44,357 | 93,562 | +49,205 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 90,752 | 90,752 | 0 | 0.18 | 0.23 | +0.05 | hold |
| Erste Asset Management GmbH | 90,000 | 90,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 64,703 | 88,057 | +23,354 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 68,120 | 83,851 | +15,731 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 134,731 | 82,753 | -51,978 | 0.00 | 0.00 | -0.00 | sell |
| Campbell & CO Investment Adviser LLC | 40,045 | 81,874 | +41,829 | 0.03 | 0.08 | +0.05 | buy |
| J. Goldman & Co LP | 236,959 | 80,998 | -155,961 | 0.13 | 0.05 | -0.08 | sell |
| Legal & General Group Plc | 63,819 | 79,220 | +15,401 | 0.00 | 0.00 | +0.00 | buy |
| PFS Partners, LLC | 79,000 | 79,000 | 0 | 0.43 | 0.60 | +0.16 | hold |
| CITIGROUP INC | 99,949 | 77,474 | -22,475 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 0 | 75,970 | +75,970 | 0.00 | 0.01 | +0.01 | buy |
| Checkpoint Capital L.P. | 50,000 | 75,000 | +25,000 | 0.21 | 0.36 | +0.14 | buy |
| TUDOR INVESTMENT CORP ET AL | 64,524 | 73,978 | +9,454 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 70,631 | 73,273 | +2,642 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 78,222 | 68,484 | -9,738 | 0.00 | 0.00 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 0 | 66,490 | +66,490 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 74,446 | 65,596 | -8,850 | 0.78 | 0.85 | +0.08 | sell |
| Steward Partners Investment Advisory, LLC | 51,525 | 63,600 | +12,075 | 0.00 | 0.01 | +0.00 | buy |
| LPL Financial LLC | 80,883 | 63,449 | -17,434 | 0.00 | 0.00 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 61,298 | 63,108 | +1,810 | 0.02 | 0.02 | +0.01 | buy |