| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vivo Capital, LLC | 0 | 1,612,903 | +1,612,903 | 0.00 | 0.45 | +0.45 | buy |
| VANGUARD GROUP INC | 2,437,451 | 3,262,381 | +824,930 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 606,227 | +606,227 | 0.00 | 0.02 | +0.02 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 122,447 | +122,447 | 0.00 | 0.03 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,146,748 | 1,264,166 | +117,418 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 321,102 | 433,642 | +112,540 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 100,517 | +100,517 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 73,193 | 164,238 | +91,045 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 81,124 | +81,124 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 76,544 | +76,544 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 33,915 | 95,232 | +61,317 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 899,861 | 952,912 | +53,051 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 49,881 | +49,881 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 260,000 | 290,500 | +30,500 | 0.65 | 0.79 | +0.13 | buy |
| CITIGROUP INC | 12,987 | 42,624 | +29,637 | 0.00 | 0.00 | +0.00 | buy |
| MPM BioImpact LLC | 1,510,174 | 1,538,517 | +28,343 | 0.70 | 0.77 | +0.07 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 24,901 | +24,901 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 24,589 | +24,589 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 19,612 | 43,910 | +24,298 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 23,405 | +23,405 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 60,819 | 81,947 | +21,128 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 20,621 | +20,621 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 18,914 | +18,914 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 51,900 | 70,700 | +18,800 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 14,948 | 33,717 | +18,769 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 13,923 | 28,558 | +14,635 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 11,096 | +11,096 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,151 | 32,197 | +11,046 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 9,641 | +9,641 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,166 | 11,930 | +6,764 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 75,218 | 81,971 | +6,753 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 88,462 | 93,962 | +5,500 | 0.07 | 0.09 | +0.02 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 134 | +134 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,604 | 3,695 | +91 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 3 | 84 | +81 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 33 | 86 | +53 | 0.00 | 0.00 | 0.00 | buy |
| MetLife Investment Management, LLC | 18,881 | 18,928 | +47 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 3,422,637 | 3,422,656 | +19 | 0.65 | 0.60 | -0.05 | buy |
| WELLS FARGO & COMPANY/MN | 23,478 | 23,488 | +10 | 0.00 | 0.00 | +0.00 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 36,502 | 36,502 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 3,438 | 3,438 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,255 | 4,255 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 4,400,000 | 4,400,000 | 0 | 0.05 | 0.05 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 185,481 | 185,481 | 0 | 0.01 | 0.01 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 15,440 | 15,440 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UNITED BANK | 31,200 | 31,200 | 0 | 0.01 | 0.01 | +0.00 | hold |
| LPL Financial LLC | 36,000 | 36,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| J. Goldman & Co LP | 148,917 | 148,917 | 0 | 0.02 | 0.02 | +0.01 | hold |
| WealthTrust Axiom LLC | 63,500 | 63,500 | 0 | 0.06 | 0.06 | +0.00 | hold |
| NEA Management Company, LLC | 11,370,376 | 11,370,376 | 0 | 2.55 | 2.07 | -0.48 | hold |
| Rubric Capital Management LP | 5,026,931 | 5,026,931 | 0 | 0.40 | 0.27 | -0.12 | hold |
| Frazier Life Sciences Management, L.P. | 7,381,090 | 7,381,090 | 0 | 1.03 | 0.99 | -0.04 | hold |
| Farther Finance Advisors, LLC | 55 | 55 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PFS Partners, LLC | 79,000 | 79,000 | 0 | 0.15 | 0.15 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 72,210 | 72,210 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 6,542 | 6,542 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NBC SECURITIES, INC. | 2,000 | 2,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 19,047 | 19,047 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,265 | 15,265 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 8,200 | 8,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 150,918 | 150,918 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,403 | 1,403 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 54,108 | 53,990 | -118 | 0.00 | 0.00 | +0.00 | sell |
| FEDERATED HERMES, INC. | 773 | 598 | -175 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 31,595 | 31,402 | -193 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 22,434 | 22,222 | -212 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 19,723 | 19,488 | -235 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,524 | 24,142 | -382 | 0.00 | 0.00 | +0.00 | sell |
| STIFEL FINANCIAL CORP | 12,303 | 11,313 | -990 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 7,061 | 3,903 | -3,158 | 0.00 | 0.00 | -0.00 | sell |
| BAILARD, INC. | 40,900 | 35,133 | -5,767 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 178,511 | 137,284 | -41,227 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 2,800,000 | 2,750,000 | -50,000 | 0.96 | 1.03 | +0.07 | sell |
| Opaleye Management Inc. | 2,645,000 | 2,567,990 | -77,010 | 1.80 | 1.43 | -0.37 | sell |
| Ally Bridge Group (NY) LLC | 1,474,926 | 1,322,800 | -152,126 | 2.62 | 2.37 | -0.25 | sell |
| Tejara Capital Ltd | 405,988 | 241,613 | -164,375 | 0.44 | 0.38 | -0.06 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 605,442 | 424,725 | -180,717 | 0.15 | 0.14 | -0.01 | sell |
| Simplify Asset Management Inc. | 200,000 | 0 | -200,000 | 0.05 | 0.00 | -0.05 | sell |
| Checkpoint Capital L.P. | 500,089 | 250,000 | -250,089 | 0.90 | 0.41 | -0.48 | sell |
| Propel Bio Management, LLC | 260,000 | 0 | -260,000 | 0.50 | 0.00 | -0.50 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 844,235 | 482,575 | -361,660 | 0.62 | 0.36 | -0.26 | sell |
| Rosalind Advisors, Inc. | 1,391,577 | 750,000 | -641,577 | 3.28 | 1.66 | -1.62 | sell |