| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 13,222,228 | 13,222,228 | 0 | 5.44 | 6.64 | +1.19 | hold |
| Frazier Life Sciences Management, L.P. | 10,259,409 | 10,259,409 | 0 | 2.24 | 2.81 | +0.57 | hold |
| BlackRock, Inc. | 8,205,006 | 9,901,053 | +1,696,047 | 0.00 | 0.00 | +0.00 | buy |
| Rubric Capital Management LP | 8,531,860 | 8,531,860 | 0 | 0.75 | 1.05 | +0.30 | hold |
| VANGUARD GROUP INC | 5,316,691 | 5,826,986 | +510,295 | 0.00 | 0.00 | +0.00 | buy |
| VIKING GLOBAL INVESTORS LP | 1,543,000 | 5,128,875 | +3,585,875 | 0.02 | 0.12 | +0.10 | buy |
| Vivo Capital, LLC | 4,487,903 | 5,094,668 | +606,765 | 2.51 | 3.75 | +1.24 | buy |
| MARSHALL WACE, LLP | 2,477,916 | 4,841,751 | +2,363,835 | 0.02 | 0.05 | +0.03 | buy |
| MORGAN STANLEY | 1,024,011 | 4,301,726 | +3,277,715 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 4,281,355 | 4,292,451 | +11,096 | 0.01 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 3,406,955 | 3,406,955 | 0 | 3.23 | 5.10 | +1.87 | hold |
| ORBIMED ADVISORS LLC | 3,308,400 | 3,308,400 | 0 | 0.46 | 0.73 | +0.27 | hold |
| FMR LLC | 368,529 | 3,299,891 | +2,931,362 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 171,982 | 3,253,888 | +3,081,906 | 0.00 | 0.01 | +0.01 | buy |
| Octagon Capital Advisors LP | 3,672,000 | 2,815,000 | -857,000 | 4.41 | 4.02 | -0.39 | sell |
| Affinity Asset Advisors, LLC | 2,534,058 | 2,800,000 | +265,942 | 2.05 | 2.38 | +0.33 | buy |
| Siren, L.L.C. | 3,938,793 | 2,536,867 | -1,401,926 | 1.11 | 0.91 | -0.21 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,786,845 | 2,220,926 | +434,081 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,832,920 | 2,219,422 | +386,502 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 850,000 | 2,200,000 | +1,350,000 | 0.62 | 1.99 | +1.37 | buy |
| ACORN CAPITAL ADVISORS, LLC | 2,144,844 | 2,144,844 | 0 | 7.67 | 9.96 | +2.29 | hold |
| Artia Global Partners LP | 1,311,840 | 1,999,702 | +687,862 | 1.85 | 3.22 | +1.37 | buy |
| BANK OF AMERICA CORP /DE/ | 1,097,497 | 1,836,839 | +739,342 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 127,585 | 1,600,742 | +1,473,157 | 0.00 | 0.02 | +0.02 | buy |
| RAYMOND JAMES FINANCIAL INC | 1,076,683 | 1,411,037 | +334,354 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,381,324 | 1,381,324 | 0 | 0.13 | 0.21 | +0.08 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,146,110 | 1,256,782 | +110,672 | 3.89 | 6.65 | +2.76 | buy |
| FLPUTNAM INVESTMENT MANAGEMENT CO | 86,952 | 1,048,102 | +961,150 | 0.01 | 0.14 | +0.14 | buy |
| Point72 Asset Management, L.P. | 1,728,676 | 941,929 | -786,747 | 0.02 | 0.02 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 225,935 | 806,331 | +580,396 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 979,098 | 792,806 | -186,292 | 0.17 | 0.27 | +0.11 | sell |
| GOLDMAN SACHS GROUP INC | 299,045 | 787,454 | +488,409 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 576,471 | 736,930 | +160,459 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 157,244 | 727,596 | +570,352 | 0.00 | 0.01 | +0.00 | buy |
| Qube Research & Technologies Ltd | 447,852 | 651,679 | +203,827 | 0.00 | 0.01 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 799,957 | 643,957 | -156,000 | 1.14 | 1.40 | +0.25 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 2,354,402 | 626,462 | -1,727,940 | 0.03 | 0.01 | -0.02 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 620,464 | +620,464 | 0.00 | 0.17 | +0.17 | buy |
| PRUDENTIAL FINANCIAL INC | 226,381 | 602,654 | +376,273 | 0.00 | 0.01 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 539,587 | 588,789 | +49,202 | 0.60 | 0.78 | +0.18 | buy |
| PANAGORA ASSET MANAGEMENT INC | 569,702 | 570,468 | +766 | 0.01 | 0.02 | +0.01 | buy |
| Informed Momentum Co LLC | 486,624 | 549,479 | +62,855 | 0.40 | 0.57 | +0.17 | buy |
| Burkehill Global Management, LP | 525,000 | 525,000 | 0 | 0.21 | 0.27 | +0.06 | hold |
| Invesco Ltd. | 322,339 | 483,070 | +160,731 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 390,000 | 390,000 | 0 | 0.43 | 0.50 | +0.07 | hold |
| STEMPOINT CAPITAL LP | 0 | 350,710 | +350,710 | 0.00 | 0.65 | +0.65 | buy |
| UBS Group AG | 354,225 | 298,612 | -55,613 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 489,300 | 293,300 | -196,000 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 166,265 | 226,339 | +60,074 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 515,476 | 216,885 | -298,591 | 0.00 | 0.00 | -0.00 | sell |
| Velan Capital Investment Management LP | 0 | 205,000 | +205,000 | 0.00 | 1.76 | +1.76 | buy |
| FRED ALGER MANAGEMENT, LLC | 59,425 | 191,045 | +131,620 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 169,459 | 183,329 | +13,870 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 824,180 | 168,994 | -655,186 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 0 | 161,700 | +161,700 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 117,245 | 123,276 | +6,031 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 120,240 | 119,930 | -310 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 116,477 | +116,477 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 106,402 | 115,022 | +8,620 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 134,150 | 105,950 | -28,200 | 0.48 | 0.60 | +0.11 | sell |
| CITADEL ADVISORS LLC | 1,319,266 | 102,534 | -1,216,732 | 0.01 | 0.00 | -0.01 | sell |
| Woodline Partners LP | 4,046,435 | 100,282 | -3,946,153 | 0.12 | 0.00 | -0.11 | sell |
| LMR Partners LLP | 100,000 | 100,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Rosalind Advisors, Inc. | 300,000 | 100,000 | -200,000 | 0.79 | 0.32 | -0.47 | sell |
| OPPENHEIMER & CO INC | 99,825 | 98,668 | -1,157 | 0.01 | 0.01 | +0.00 | sell |
| MAI Capital Management | 847,553 | 98,492 | -749,061 | 0.03 | 0.01 | -0.03 | sell |
| NAN FUNG TRINITY (HK) Ltd | 0 | 89,575 | +89,575 | 0.00 | 0.08 | +0.08 | buy |
| DIADEMA PARTNERS LP | 185,830 | 85,830 | -100,000 | 0.63 | 0.55 | -0.08 | sell |
| SEI INVESTMENTS CO | 0 | 85,798 | +85,798 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 8,446 | 81,972 | +73,526 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,497 | 81,697 | +77,200 | 0.00 | 0.00 | +0.00 | buy |
| PFS Partners, LLC | 79,000 | 79,000 | 0 | 0.22 | 0.34 | +0.13 | hold |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 73,287 | +73,287 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 64,545 | +64,545 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 63,149 | +63,149 | 0.00 | 0.01 | +0.01 | buy |
| WealthTrust Axiom LLC | 61,500 | 61,500 | 0 | 0.10 | 0.15 | +0.05 | hold |
| Optimize Financial Inc | 0 | 60,599 | +60,599 | 0.00 | 0.29 | +0.29 | buy |
| JPMORGAN CHASE & CO | 54,342 | 58,815 | +4,473 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 64,294 | 58,292 | -6,002 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 4,536 | 56,460 | +51,924 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 41,171 | 55,686 | +14,515 | 0.00 | 0.00 | +0.00 | buy |
| DLD Asset Management, LP | 0 | 55,000 | +55,000 | 0.00 | 0.06 | +0.06 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 27,851 | 54,933 | +27,082 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 43,437 | 51,640 | +8,203 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 100,001 | 50,861 | -49,140 | 0.01 | 0.01 | -0.00 | sell |
| MetLife Investment Management, LLC | 44,656 | 50,752 | +6,096 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 49,918 | 49,878 | -40 | 0.00 | 0.00 | +0.00 | sell |
| Graham Capital Management, L.P. | 40,061 | 49,043 | +8,982 | 0.01 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 38,552 | 46,859 | +8,307 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 43,506 | +43,506 | 0.00 | 0.03 | +0.03 | buy |
| AQR CAPITAL MANAGEMENT LLC | 24,830 | 42,810 | +17,980 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 62,439 | 41,634 | -20,805 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 126,924 | 41,443 | -85,481 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41,545 | 40,625 | -920 | 0.00 | 0.00 | +0.00 | sell |
| LPL Financial LLC | 0 | 40,450 | +40,450 | 0.00 | 0.00 | +0.00 | buy |
| Tejara Capital Ltd | 326,395 | 37,200 | -289,195 | 0.83 | 0.19 | -0.64 | sell |
| JANUS HENDERSON GROUP PLC | 0 | 37,127 | +37,127 | 0.00 | 0.00 | +0.00 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 36,502 | 36,502 | 0 | 0.02 | 0.03 | +0.01 | hold |
| CHAPIN DAVIS, INC. | 0 | 35,100 | +35,100 | 0.00 | 0.08 | +0.08 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 34,399 | +34,399 | 0.00 | 0.02 | +0.02 | buy |