| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Tejara Capital Ltd | 180,227 | 1,269,000 | +1,088,773 | 0.22 | 0.71 | +0.49 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 910,094 | +910,094 | 0.00 | 0.11 | +0.11 | buy |
| Opaleye Management Inc. | 1,705,900 | 2,535,000 | +829,100 | 1.21 | 0.90 | -0.31 | buy |
| Frazier Life Sciences Management, L.P. | 6,881,090 | 7,381,090 | +500,000 | 1.00 | 0.53 | -0.47 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 67,300 | 542,700 | +475,400 | 0.00 | 0.00 | +0.00 | buy |
| Anson Funds Management LP | 0 | 420,803 | +420,803 | 0.00 | 0.11 | +0.11 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 300,000 | +300,000 | 0.00 | 0.04 | +0.04 | buy |
| VANGUARD GROUP INC | 1,957,875 | 2,243,399 | +285,524 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 185,058 | +185,058 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 9,666 | 132,209 | +122,543 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 119,793 | +119,793 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 99,491 | +99,491 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 19,597 | 98,253 | +78,656 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 787,640 | 849,881 | +62,241 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 13,285 | 63,797 | +50,512 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 708,593 | 741,193 | +32,600 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 186,481 | 211,481 | +25,000 | 0.01 | 0.01 | -0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 10,951 | +10,951 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 0 | 10,100 | +10,100 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 43 | 6,956 | +6,913 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 16,046 | 19,888 | +3,842 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 1,580 | 3,511 | +1,931 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 38,520 | 39,648 | +1,128 | 0.02 | 0.01 | -0.01 | buy |
| Tower Research Capital LLC (TRC) | 6,453 | 7,557 | +1,104 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 950 | +950 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 20,775 | 20,951 | +176 | 0.00 | 0.00 | -0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,438 | 3,438 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 4,400,000 | 4,400,000 | 0 | 0.04 | 0.02 | -0.02 | hold |
| UNITED BANK | 28,450 | 28,450 | 0 | 0.01 | 0.00 | -0.00 | hold |
| J. Goldman & Co LP | 137,873 | 137,873 | 0 | 0.02 | 0.01 | -0.00 | hold |
| NEA Management Company, LLC | 11,370,376 | 11,370,376 | 0 | 1.91 | 1.02 | -0.90 | hold |
| VR Adviser, LLC | 3,422,397 | 3,422,397 | 0 | 0.79 | 0.31 | -0.47 | hold |
| Rubric Capital Management LP | 5,684,420 | 5,684,420 | 0 | 0.52 | 0.28 | -0.24 | hold |
| Legal & General Group Plc | 3,974 | 3,974 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NBC SECURITIES, INC. | 2,000 | 2,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 8,700 | 8,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 107,707 | 107,707 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 36,785 | 36,702 | -83 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 21,427 | 21,063 | -364 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 4,049 | 3,631 | -418 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 134,080 | 133,381 | -699 | 0.00 | 0.00 | -0.00 | sell |
| PFS Partners, LLC | 100,000 | 99,000 | -1,000 | 0.19 | 0.09 | -0.10 | sell |
| NORTHERN TRUST CORP | 315,556 | 314,178 | -1,378 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 26,150 | 23,915 | -2,235 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,185 | 6,938 | -2,247 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 54,272 | 51,464 | -2,808 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 17,460 | 0 | -17,460 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 18,382 | 0 | -18,382 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 24,600 | 0 | -24,600 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 25,070 | 0 | -25,070 | 0.00 | 0.00 | -0.00 | sell |
| WealthTrust Axiom LLC | 93,500 | 63,500 | -30,000 | 0.07 | 0.03 | -0.04 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 927,415 | 863,883 | -63,532 | 0.75 | 0.36 | -0.40 | sell |
| TRUST CO OF TOLEDO NA /OH/ | 117,145 | 36,502 | -80,643 | 0.05 | 0.01 | -0.04 | sell |
| Fairmount Funds Management LLC | 5,163,287 | 0 | -5,163,287 | 1.35 | 0.00 | -1.35 | sell |