| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 0 | 4,150,237 | +4,150,237 | 0.00 | 0.05 | +0.05 | buy |
| Frazier Life Sciences Management, L.P. | 7,381,090 | 10,664,774 | +3,283,684 | 0.99 | 1.82 | +0.84 | buy |
| Siren, L.L.C. | 0 | 2,906,060 | +2,906,060 | 0.00 | 0.53 | +0.53 | buy |
| Woodline Partners LP | 606,227 | 3,212,597 | +2,606,370 | 0.02 | 0.09 | +0.07 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 2,500,000 | +2,500,000 | 0.00 | 0.02 | +0.02 | buy |
| Vivo Capital, LLC | 1,612,903 | 3,487,903 | +1,875,000 | 0.45 | 1.61 | +1.16 | buy |
| MPM BioImpact LLC | 1,538,517 | 3,094,896 | +1,556,379 | 0.77 | 1.81 | +1.04 | buy |
| CITADEL ADVISORS LLC | 49,881 | 1,233,176 | +1,183,295 | 0.00 | 0.00 | +0.00 | buy |
| Checkpoint Capital L.P. | 250,000 | 1,084,135 | +834,135 | 0.41 | 2.27 | +1.86 | buy |
| BlackRock, Inc. | 3,221,752 | 3,928,462 | +706,710 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 290,500 | 771,958 | +481,458 | 0.79 | 3.20 | +2.41 | buy |
| J. Goldman & Co LP | 148,917 | 537,609 | +388,692 | 0.02 | 0.08 | +0.06 | buy |
| Ikarian Capital, LLC | 0 | 325,000 | +325,000 | 0.00 | 0.38 | +0.38 | buy |
| Rosalind Advisors, Inc. | 750,000 | 1,062,500 | +312,500 | 1.66 | 2.36 | +0.70 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 482,575 | 734,234 | +251,659 | 0.36 | 0.68 | +0.31 | buy |
| VANGUARD GROUP INC | 3,262,381 | 3,509,213 | +246,832 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 952,912 | 1,170,682 | +217,770 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 20,621 | 180,419 | +159,798 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 135,807 | +135,807 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 100,517 | 221,664 | +121,147 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 24,901 | 120,304 | +95,403 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 93,859 | +93,859 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 89,309 | +89,309 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 164,238 | 236,144 | +71,906 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 70,317 | +70,317 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 0 | 67,201 | +67,201 | 0.00 | 0.02 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 64,500 | +64,500 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 33,717 | 96,784 | +63,067 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 72,210 | 134,353 | +62,143 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 95,232 | 156,267 | +61,035 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 50,000 | 100,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 433,642 | 482,815 | +49,173 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,264,166 | 1,299,322 | +35,156 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 33,097 | +33,097 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 70,700 | 100,400 | +29,700 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 1,327,285 | 1,356,886 | +29,601 | 0.04 | 0.04 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 53,990 | 78,143 | +24,153 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 23,032 | +23,032 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 150,918 | 173,063 | +22,145 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 21,589 | +21,589 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 21,255 | +21,255 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 18,928 | 38,785 | +19,857 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 16,298 | +16,298 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 15,900 | +15,900 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 9,641 | 24,913 | +15,272 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 14,059 | +14,059 | 0.00 | 0.00 | +0.00 | buy |
| Centiva Capital, LP | 0 | 10,048 | +10,048 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 11,096 | 20,685 | +9,589 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 23,488 | 33,050 | +9,562 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 18,914 | 27,663 | +8,749 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 19,047 | 25,166 | +6,119 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 42,624 | 47,856 | +5,232 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 19,488 | 23,621 | +4,133 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 23,405 | 26,792 | +3,387 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 137,284 | 140,219 | +2,935 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,438 | 6,332 | +2,894 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 2,561 | +2,561 | 0.00 | 0.00 | +0.00 | buy |
| WealthTrust Axiom LLC | 63,500 | 65,500 | +2,000 | 0.06 | 0.08 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,197 | 33,698 | +1,501 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 43,910 | 44,753 | +843 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 109 | 809 | +700 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 28,558 | 29,243 | +685 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,695 | 4,360 | +665 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,255 | 4,497 | +242 | 0.00 | 0.00 | +0.00 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 36,502 | 36,502 | 0 | 0.02 | 0.02 | +0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 4,400,000 | 4,400,000 | 0 | 0.05 | 0.06 | +0.01 | hold |
| ALLIANCEBERNSTEIN L.P. | 15,440 | 15,440 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UNITED BANK | 31,200 | 31,200 | 0 | 0.01 | 0.02 | +0.00 | hold |
| LPL Financial LLC | 36,000 | 36,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEA Management Company, LLC | 11,370,376 | 11,370,376 | 0 | 2.07 | 2.76 | +0.69 | hold |
| Farther Finance Advisors, LLC | 55 | 55 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PFS Partners, LLC | 79,000 | 79,000 | 0 | 0.15 | 0.18 | +0.03 | hold |
| Legal & General Group Plc | 6,542 | 6,542 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,265 | 15,265 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 8,200 | 8,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 1,403 | 1,403 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 84 | 0 | -84 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 86 | 0 | -86 | 0.00 | 0.00 | 0.00 | sell |
| EARNED WEALTH ADVISORS, LLC | 134 | 0 | -134 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 11,313 | 11,015 | -298 | 0.00 | 0.00 | +0.00 | sell |
| OPPENHEIMER & CO INC | 81,947 | 81,403 | -544 | 0.00 | 0.01 | +0.00 | sell |
| FEDERATED HERMES, INC. | 598 | 0 | -598 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 24,142 | 23,431 | -711 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,903 | 2,652 | -1,251 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 31,402 | 30,091 | -1,311 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 22,222 | 20,889 | -1,333 | 0.00 | 0.00 | +0.00 | sell |
| NBC SECURITIES, INC. | 2,000 | 2 | -1,998 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 81,971 | 79,874 | -2,097 | 0.00 | 0.00 | +0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 122,447 | 120,212 | -2,235 | 0.03 | 0.04 | +0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 11,930 | 7,686 | -4,244 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 185,481 | 177,481 | -8,000 | 0.01 | 0.02 | +0.00 | sell |
| ALGERT GLOBAL LLC | 24,589 | 14,779 | -9,810 | 0.00 | 0.00 | -0.00 | sell |
| BAILARD, INC. | 35,133 | 0 | -35,133 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 81,124 | 42,921 | -38,203 | 0.00 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 76,544 | 0 | -76,544 | 0.00 | 0.00 | -0.00 | sell |
| Tejara Capital Ltd | 241,613 | 153,739 | -87,874 | 0.38 | 0.42 | +0.03 | sell |
| Shay Capital LLC | 93,962 | 0 | -93,962 | 0.09 | 0.00 | -0.09 | sell |
| Opaleye Management Inc. | 2,567,990 | 2,317,500 | -250,490 | 1.43 | 1.67 | +0.24 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 424,725 | 52,085 | -372,640 | 0.14 | 0.02 | -0.12 | sell |