| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Frazier Life Sciences Management, L.P. | 7,381,090 | 10,664,774 | +3,283,684 | 0.99 | 1.82 | +0.84 | buy |
| Woodline Partners LP | 606,227 | 3,212,597 | +2,606,370 | 0.02 | 0.09 | +0.07 | buy |
| Vivo Capital, LLC | 1,612,903 | 3,487,903 | +1,875,000 | 0.45 | 1.61 | +1.16 | buy |
| MPM BioImpact LLC | 1,538,517 | 3,094,896 | +1,556,379 | 0.77 | 1.81 | +1.04 | buy |
| Checkpoint Capital L.P. | 250,000 | 1,084,135 | +834,135 | 0.41 | 2.27 | +1.86 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 290,500 | 771,958 | +481,458 | 0.79 | 3.20 | +2.41 | buy |
| J. Goldman & Co LP | 148,917 | 537,609 | +388,692 | 0.01 | 0.06 | +0.04 | buy |
| Rosalind Advisors, Inc. | 750,000 | 1,062,500 | +312,500 | 1.60 | 2.24 | +0.63 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 482,575 | 734,234 | +251,659 | 0.36 | 0.68 | +0.31 | buy |
| Hudson Bay Capital Management LP | 50,000 | 100,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 185,481 | 177,481 | +8,000 | 0.01 | 0.02 | 0.00 | sell |
| WealthTrust Axiom LLC | 63,500 | 65,500 | +2,000 | 0.06 | 0.08 | +0.02 | buy |
| Tejara Capital Ltd | 241,613 | 153,739 | -87,874 | 0.38 | 0.42 | +0.03 | sell |
| Opaleye Management Inc. | 2,567,990 | 2,317,500 | -250,490 | 1.43 | 1.67 | +0.24 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 424,725 | 52,085 | -372,640 | 0.14 | 0.02 | -0.12 | sell |
| Ally Bridge Group (NY) LLC | 1,322,800 | 781,489 | -541,311 | 2.37 | 2.76 | +0.40 | sell |
| Rubric Capital Management LP | 5,026,931 | 4,205,129 | -821,802 | 0.27 | 0.22 | -0.05 | sell |
| Logos Global Management LP | 2,750,000 | 1,250,000 | -1,500,000 | 1.03 | 0.60 | -0.43 | sell |
| VR Adviser, LLC | 3,422,656 | 1,266,457 | -2,156,199 | 0.60 | 0.36 | -0.24 | sell |