| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 13,222,228 | 13,222,228 | 0 | 6.64 | 8.44 | +1.80 | hold |
| Frazier Life Sciences Management, L.P. | 10,259,409 | 10,259,409 | 0 | 2.81 | 3.45 | +0.64 | hold |
| BlackRock, Inc. | 9,901,053 | 10,126,183 | +225,130 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,299,891 | 6,500,009 | +3,200,118 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 5,826,986 | 6,434,655 | +607,669 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 5,094,668 | 5,094,668 | 0 | 3.75 | 4.12 | +0.37 | hold |
| MARSHALL WACE, LLP | 4,841,751 | 4,580,548 | -261,203 | 0.05 | 0.06 | +0.01 | sell |
| Rubric Capital Management LP | 8,531,860 | 3,766,749 | -4,765,111 | 1.05 | 0.56 | -0.48 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 3,253,888 | 3,403,990 | +150,102 | 0.01 | 0.01 | +0.00 | buy |
| MPM BioImpact LLC | 3,406,955 | 3,287,087 | -119,868 | 5.10 | 4.71 | -0.39 | sell |
| VIKING GLOBAL INVESTORS LP | 5,128,875 | 3,198,644 | -1,930,231 | 0.12 | 0.11 | -0.02 | sell |
| ORBIMED ADVISORS LLC | 3,308,400 | 3,190,700 | -117,700 | 0.73 | 0.82 | +0.09 | sell |
| ALLIANCEBERNSTEIN L.P. | 4,292,451 | 3,082,986 | -1,209,465 | 0.01 | 0.01 | -0.00 | sell |
| Octagon Capital Advisors LP | 2,815,000 | 2,815,000 | 0 | 4.02 | 4.41 | +0.39 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,381,324 | 2,622,306 | +1,240,982 | 0.21 | 0.51 | +0.31 | buy |
| STATE STREET CORP | 2,219,422 | 2,435,000 | +215,578 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,220,926 | 2,412,885 | +191,959 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 2,536,867 | 2,286,867 | -250,000 | 0.91 | 0.85 | -0.05 | sell |
| Affinity Asset Advisors, LLC | 2,800,000 | 2,150,172 | -649,828 | 2.38 | 1.93 | -0.45 | sell |
| ACORN CAPITAL ADVISORS, LLC | 2,144,844 | 2,144,844 | 0 | 9.96 | 9.10 | -0.86 | hold |
| Artia Global Partners LP | 1,999,702 | 2,013,602 | +13,900 | 3.22 | 4.05 | +0.83 | buy |
| EMERALD ADVISERS, LLC | 0 | 1,892,276 | +1,892,276 | 0.00 | 0.73 | +0.73 | buy |
| RAYMOND JAMES FINANCIAL INC | 1,411,037 | 1,766,963 | +355,926 | 0.00 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 2,200,000 | 1,550,000 | -650,000 | 1.99 | 1.29 | -0.70 | sell |
| Pictet Asset Management Holding SA | 11,259 | 1,532,013 | +1,520,754 | 0.00 | 0.02 | +0.02 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 1,272,373 | +1,272,373 | 0.00 | 0.78 | +0.78 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,256,782 | 1,256,782 | 0 | 6.65 | 6.08 | -0.56 | hold |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 1,108,468 | +1,108,468 | 0.00 | 0.15 | +0.15 | buy |
| BANK OF AMERICA CORP /DE/ | 1,836,839 | 1,094,851 | -741,988 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 787,454 | 1,056,891 | +269,437 | 0.00 | 0.00 | +0.00 | buy |
| FLPUTNAM INVESTMENT MANAGEMENT CO | 1,048,102 | 1,053,427 | +5,325 | 0.14 | 0.19 | +0.05 | buy |
| MORGAN STANLEY | 4,301,726 | 1,050,296 | -3,251,430 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 100,282 | 1,000,282 | +900,000 | 0.00 | 0.05 | +0.04 | buy |
| Point72 Asset Management, L.P. | 941,929 | 1,000,000 | +58,071 | 0.02 | 0.02 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 89,575 | 917,450 | +827,875 | 0.08 | 0.91 | +0.83 | buy |
| Soleus Capital Management, L.P. | 25,000 | 900,000 | +875,000 | 0.01 | 0.48 | +0.47 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 806,331 | 836,800 | +30,469 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,600,742 | 825,548 | -775,194 | 0.02 | 0.01 | -0.01 | sell |
| NORTHERN TRUST CORP | 736,930 | 761,966 | +25,036 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 570,468 | 693,001 | +122,533 | 0.02 | 0.03 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 643,957 | 598,534 | -45,423 | 1.40 | 1.57 | +0.17 | sell |
| BARCLAYS PLC | 216,885 | 582,653 | +365,768 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 727,596 | 570,226 | -157,370 | 0.01 | 0.01 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 602,654 | 549,219 | -53,435 | 0.01 | 0.01 | +0.00 | sell |
| Informed Momentum Co LLC | 549,479 | 541,242 | -8,237 | 0.57 | 0.75 | +0.19 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 588,789 | 541,240 | -47,549 | 0.78 | 0.98 | +0.20 | sell |
| Burkehill Global Management, LP | 525,000 | 525,000 | 0 | 0.27 | 0.43 | +0.16 | hold |
| PEREGRINE CAPITAL MANAGEMENT LLC | 620,464 | 507,685 | -112,779 | 0.17 | 0.19 | +0.02 | sell |
| Invesco Ltd. | 483,070 | 498,926 | +15,856 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 792,806 | 444,357 | -348,449 | 0.27 | 0.22 | -0.06 | sell |
| STEMPOINT CAPITAL LP | 350,710 | 399,557 | +48,847 | 0.65 | 0.86 | +0.21 | buy |
| Opaleye Management Inc. | 390,000 | 345,100 | -44,900 | 0.50 | 0.57 | +0.07 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 324,172 | +324,172 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 298,612 | 274,628 | -23,984 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 226,339 | 260,587 | +34,248 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 0 | 241,483 | +241,483 | 0.00 | 0.11 | +0.11 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 15,180 | 226,215 | +211,035 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 205,000 | 205,000 | 0 | 1.76 | 1.49 | -0.27 | hold |
| Nuveen, LLC | 183,329 | 183,329 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 626,462 | 174,641 | -451,821 | 0.01 | 0.00 | -0.01 | sell |
| Swiss National Bank | 161,700 | 168,200 | +6,500 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 191,045 | 157,980 | -33,065 | 0.01 | 0.01 | +0.00 | sell |
| CITADEL ADVISORS LLC | 102,534 | 152,855 | +50,321 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 148,292 | +148,292 | 0.00 | 0.99 | +0.99 | buy |
| SEI INVESTMENTS CO | 85,798 | 147,941 | +62,143 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 141,312 | +141,312 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 116,477 | 140,733 | +24,256 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 6,739 | 130,000 | +123,261 | 0.00 | 0.07 | +0.07 | buy |
| HRT FINANCIAL LP | 0 | 125,104 | +125,104 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 64,545 | 124,562 | +60,017 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 26,913 | 123,498 | +96,585 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 123,276 | 120,566 | -2,710 | 0.00 | 0.00 | +0.00 | sell |
| HighVista Strategies LLC | 0 | 106,159 | +106,159 | 0.00 | 0.34 | +0.34 | buy |
| RHUMBLINE ADVISERS | 115,022 | 105,922 | -9,100 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 55,686 | 101,279 | +45,593 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 98,668 | 100,698 | +2,030 | 0.01 | 0.02 | +0.01 | buy |
| LMR Partners LLP | 100,000 | 100,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Rosalind Advisors, Inc. | 100,000 | 100,000 | 0 | 0.32 | 0.46 | +0.13 | hold |
| DIADEMA PARTNERS LP | 85,830 | 97,184 | +11,354 | 0.55 | 0.72 | +0.18 | buy |
| Erste Asset Management GmbH | 0 | 90,000 | +90,000 | 0.00 | 0.01 | +0.01 | buy |
| SECTORAL ASSET MANAGEMENT INC | 105,950 | 84,255 | -21,695 | 0.60 | 0.85 | +0.25 | sell |
| XTX Topco Ltd | 0 | 83,818 | +83,818 | 0.00 | 0.03 | +0.03 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 81,697 | 83,788 | +2,091 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 119,930 | 83,755 | -36,175 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 424 | 83,027 | +82,603 | 0.00 | 0.00 | +0.00 | buy |
| WEXFORD CAPITAL LP | 0 | 82,034 | +82,034 | 0.00 | 0.26 | +0.26 | buy |
| Legal & General Group Plc | 81,972 | 81,673 | -299 | 0.00 | 0.00 | +0.00 | sell |
| PFS Partners, LLC | 79,000 | 79,000 | 0 | 0.34 | 0.45 | +0.11 | hold |
| MAI Capital Management | 98,492 | 77,769 | -20,723 | 0.01 | 0.01 | -0.00 | sell |
| Hudson Bay Capital Management LP | 0 | 75,000 | +75,000 | 0.00 | 0.01 | +0.01 | buy |
| Campbell & CO Investment Adviser LLC | 24,885 | 71,097 | +46,212 | 0.02 | 0.04 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 51,640 | 70,833 | +19,193 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 68,481 | +68,481 | 0.00 | 0.00 | +0.00 | buy |
| WealthTrust Axiom LLC | 61,500 | 61,500 | 0 | 0.15 | 0.20 | +0.05 | hold |
| Optimize Financial Inc | 60,599 | 61,483 | +884 | 0.29 | 0.39 | +0.10 | buy |
| JPMORGAN CHASE & CO | 58,815 | 59,475 | +660 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 56,460 | 59,444 | +2,984 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 54,933 | 56,269 | +1,336 | 0.01 | 0.01 | +0.00 | buy |
| LPL Financial LLC | 40,450 | 52,960 | +12,510 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 52,800 | +52,800 | 0.00 | 0.00 | +0.00 | buy |