| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 1,381,324 | 2,622,306 | +1,240,982 | 0.21 | 0.51 | +0.31 | buy |
| Soleus Capital Management, L.P. | 25,000 | 900,000 | +875,000 | 0.01 | 0.48 | +0.47 | buy |
| NAN FUNG TRINITY (HK) Ltd | 89,575 | 917,450 | +827,875 | 0.08 | 0.91 | +0.83 | buy |
| BIT Capital GmbH | 6,739 | 130,000 | +123,261 | 0.00 | 0.06 | +0.06 | buy |
| STEMPOINT CAPITAL LP | 350,710 | 399,557 | +48,847 | 0.65 | 0.86 | +0.21 | buy |
| Persistent Asset Partners Ltd | 19,688 | 45,830 | +26,142 | 0.13 | 0.28 | +0.15 | buy |
| MAI Capital Management | 98,492 | 77,769 | +20,723 | 0.01 | 0.01 | -0.00 | sell |
| Artia Global Partners LP | 1,999,702 | 2,013,602 | +13,900 | 3.22 | 4.05 | +0.83 | buy |
| DIADEMA PARTNERS LP | 85,830 | 97,184 | +11,354 | 0.55 | 0.72 | +0.18 | buy |
| AXQ CAPITAL, LP | 15,524 | 22,204 | +6,680 | 0.05 | 0.06 | +0.01 | buy |
| FLPUTNAM INVESTMENT MANAGEMENT CO | 1,048,102 | 1,053,427 | +5,325 | 0.14 | 0.19 | +0.05 | buy |
| OPPENHEIMER & CO INC | 98,668 | 100,698 | +2,030 | 0.01 | 0.02 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 54,933 | 56,269 | +1,336 | 0.01 | 0.01 | +0.00 | buy |
| Optimize Financial Inc | 60,599 | 61,483 | +884 | 0.29 | 0.39 | +0.10 | buy |
| Chung Wu Investment Group, LLC | 1,600 | 2,000 | +400 | 0.01 | 0.02 | +0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,620 | 2,519 | -101 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 21,346 | 20,895 | -451 | 0.02 | 0.02 | +0.00 | sell |
| Informed Momentum Co LLC | 549,479 | 541,242 | -8,237 | 0.57 | 0.75 | +0.19 | sell |
| CHAPIN DAVIS, INC. | 35,100 | 20,100 | -15,000 | 0.08 | 0.06 | -0.02 | sell |
| SECTORAL ASSET MANAGEMENT INC | 105,950 | 84,255 | -21,695 | 0.60 | 0.85 | +0.25 | sell |
| FRED ALGER MANAGEMENT, LLC | 191,045 | 157,980 | -33,065 | 0.01 | 0.01 | +0.00 | sell |
| Opaleye Management Inc. | 390,000 | 345,100 | -44,900 | 0.50 | 0.57 | +0.07 | sell |
| DLD Asset Management, LP | 55,000 | 10,000 | -45,000 | 0.04 | 0.01 | -0.03 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 643,957 | 598,534 | -45,423 | 1.24 | 1.45 | +0.21 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 588,789 | 541,240 | -47,549 | 0.78 | 0.98 | +0.20 | sell |
| PEREGRINE CAPITAL MANAGEMENT LLC | 620,464 | 507,685 | -112,779 | 0.17 | 0.19 | +0.02 | sell |
| ORBIMED ADVISORS LLC | 3,308,400 | 3,190,700 | -117,700 | 0.73 | 0.82 | +0.09 | sell |
| MPM BioImpact LLC | 3,406,955 | 3,287,087 | -119,868 | 5.10 | 4.71 | -0.39 | sell |
| Siren, L.L.C. | 2,536,867 | 2,286,867 | -250,000 | 0.91 | 0.85 | -0.05 | sell |
| J. Goldman & Co LP | 792,806 | 444,357 | -348,449 | 0.18 | 0.15 | -0.04 | sell |
| Affinity Asset Advisors, LLC | 2,800,000 | 2,150,172 | -649,828 | 2.38 | 1.93 | -0.45 | sell |
| Logos Global Management LP | 2,200,000 | 1,550,000 | -650,000 | 1.99 | 1.29 | -0.70 | sell |
| VIKING GLOBAL INVESTORS LP | 5,128,875 | 3,198,644 | -1,930,231 | 0.12 | 0.11 | -0.02 | sell |
| Rubric Capital Management LP | 8,531,860 | 3,766,749 | -4,765,111 | 0.88 | 0.56 | -0.32 | sell |