| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Exome Asset Management LLC | 118,100 | 415,434 | +297,334 | 0.27 | 1.09 | +0.82 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 219,800 | +219,800 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 0 | 175,372 | +175,372 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 110,091 | +110,091 | 0.00 | 0.09 | +0.09 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 86,383 | +86,383 | 0.00 | 0.07 | +0.07 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 60,323 | +60,323 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 46,376 | 80,576 | +34,200 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 49,582 | 69,633 | +20,051 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 16,199 | +16,199 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 94,343 | 106,775 | +12,432 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,241 | +1,241 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 445,434 | 445,434 | 0 | 0.09 | 0.15 | +0.06 | hold |
| CITADEL ADVISORS LLC | 1,181,088 | 1,181,088 | 0 | 0.00 | 0.00 | +0.00 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,394,336 | 1,394,336 | 0 | 0.05 | 0.05 | -0.00 | hold |
| Cormorant Asset Management, LP | 1,394,336 | 1,394,336 | 0 | 0.16 | 0.19 | +0.03 | hold |
| Russell Investments Group, Ltd. | 187 | 187 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parkman Healthcare Partners LLC | 696,470 | 696,470 | 0 | 0.23 | 0.26 | +0.03 | hold |
| MB, LEVIS & ASSOCIATES, LLC | 1,041 | 1,041 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHERN TRUST CORP | 36,951 | 36,951 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 11,665 | 11,665 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Indiana Trust & Investment Management Co | 12 | 0 | -12 | 0.00 | 0.00 | -0.00 | sell |
| Steward Partners Investment Advisory, LLC | 22 | 0 | -22 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 4,444 | 0 | -4,444 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 17,273 | 10,990 | -6,283 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 10,043 | 0 | -10,043 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 118,100 | 94,600 | -23,500 | 0.02 | 0.02 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 60,055 | 0 | -60,055 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 703,868 | 0 | -703,868 | 0.18 | 0.00 | -0.18 | sell |