| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DAFNA Capital Management LLC | 0 | 636,103 | +636,103 | 0.00 | 0.28 | +0.28 | buy |
| ACORN CAPITAL ADVISORS, LLC | 456,970 | 785,938 | +328,968 | 0.82 | 0.83 | +0.00 | buy |
| Patient Square Capital LP | 0 | 257,033 | +257,033 | 0.00 | 0.17 | +0.17 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 154,134 | 344,134 | +190,000 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 353,434 | 462,801 | +109,367 | 0.89 | 0.65 | -0.24 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 24,943 | 115,143 | +90,200 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 59,400 | 141,502 | +82,102 | 0.02 | 0.02 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 0 | 70,419 | +70,419 | 0.00 | 0.02 | +0.02 | buy |
| Parkman Healthcare Partners LLC | 152,973 | 217,978 | +65,005 | 0.07 | 0.04 | -0.03 | buy |
| HRT FINANCIAL LP | 0 | 26,242 | +26,242 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 19,574 | +19,574 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 18,015 | +18,015 | 0.00 | 0.01 | +0.01 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 36,958 | 51,958 | +15,000 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 21,018 | 33,052 | +12,034 | 0.01 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,386 | 4,296 | +2,910 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 475,129 | 475,650 | +521 | 0.00 | 0.00 | -0.00 | buy |
| Truvestments Capital LLC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 445,434 | 445,434 | 0 | 0.23 | 0.13 | -0.10 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,394,336 | 1,394,336 | 0 | 0.08 | 0.05 | -0.03 | hold |
| CWM, LLC | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Centerpoint Advisors, LLC | 350 | 350 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MB, LEVIS & ASSOCIATES, LLC | 1,041 | 1,041 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 18,298 | 18,298 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 23,971 | 23,971 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 15,765 | 15,765 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BlackRock, Inc. | 83,314 | 82,579 | -735 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 135,017 | 133,490 | -1,527 | 0.00 | 0.00 | -0.00 | sell |
| BFSG, LLC | 3,500 | 0 | -3,500 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 25,229 | 0 | -25,229 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 176,658 | 84,978 | -91,680 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,230,457 | 1,100,329 | -130,128 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 245,800 | 45,557 | -200,243 | 0.02 | 0.00 | -0.02 | sell |
| Cormorant Asset Management, LP | 1,394,336 | 0 | -1,394,336 | 0.26 | 0.00 | -0.26 | sell |