| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SILVERARC CAPITAL MANAGEMENT, LLC | 86,383 | 467,397 | +381,014 | 0.07 | 0.23 | +0.15 | buy |
| VANGUARD GROUP INC | 69,633 | 443,518 | +373,885 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 110,091 | 171,217 | +61,126 | 0.09 | 0.07 | -0.02 | buy |
| CITADEL ADVISORS LLC | 1,181,088 | 1,211,066 | +29,978 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 106,775 | 135,670 | +28,895 | 0.00 | 0.00 | -0.00 | buy |
| Lynx1 Capital Management LP | 0 | 16,194 | +16,194 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 11,665 | 15,765 | +4,100 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,241 | 3,383 | +2,142 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 36,951 | 37,655 | +704 | 0.00 | 0.00 | -0.00 | buy |
| Centerpoint Advisors, LLC | 0 | 350 | +350 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 445,434 | 445,434 | 0 | 0.15 | 0.10 | -0.05 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,394,336 | 1,394,336 | 0 | 0.05 | 0.05 | +0.00 | hold |
| Cormorant Asset Management, LP | 1,394,336 | 1,394,336 | 0 | 0.19 | 0.16 | -0.03 | hold |
| Russell Investments Group, Ltd. | 187 | 187 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MB, LEVIS & ASSOCIATES, LLC | 1,041 | 1,041 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Schonfeld Strategic Advisors LLC | 219,800 | 216,223 | -3,577 | 0.01 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 10,990 | 0 | -10,990 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 16,199 | 0 | -16,199 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 80,576 | 63,111 | -17,465 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 94,600 | 65,034 | -29,566 | 0.02 | 0.01 | -0.01 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 60,323 | 0 | -60,323 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 415,434 | 353,434 | -62,000 | 1.09 | 0.62 | -0.47 | sell |
| ROYAL BANK OF CANADA | 175,372 | 0 | -175,372 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 696,470 | 345,206 | -351,264 | 0.26 | 0.09 | -0.17 | sell |