| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Cormorant Asset Management, LP | 0 | 1,370,938 | +1,370,938 | 0.00 | 0.17 | +0.17 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 570,740 | +570,740 | 0.00 | 0.02 | +0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 344,134 | 644,134 | +300,000 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 290,000 | +290,000 | 0.00 | 0.16 | +0.16 | buy |
| JANE STREET GROUP, LLC | 0 | 124,822 | +124,822 | 0.00 | 0.00 | +0.00 | buy |
| TFG Asset Management GP Ltd | 0 | 115,384 | +115,384 | 0.00 | 0.03 | +0.03 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 106,459 | +106,459 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 78,474 | +78,474 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 84,978 | 161,951 | +76,973 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 257,033 | 317,033 | +60,000 | 0.17 | 0.19 | +0.02 | buy |
| Harvest Investment Services, LLC | 0 | 51,326 | +51,326 | 0.00 | 0.02 | +0.02 | buy |
| Velan Capital Investment Management LP | 0 | 30,000 | +30,000 | 0.00 | 0.05 | +0.05 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 51,958 | 76,958 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 33,052 | 56,908 | +23,856 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 22,418 | +22,418 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 475,650 | 496,297 | +20,647 | 0.00 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 26,242 | 42,037 | +15,795 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 13,466 | +13,466 | 0.00 | 0.00 | +0.00 | buy |
| CORSAIR CAPITAL MANAGEMENT, L.P. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 445,434 | 445,434 | 0 | 0.13 | 0.16 | +0.02 | hold |
| DAFNA Capital Management LLC | 636,103 | 636,103 | 0 | 0.28 | 0.29 | +0.00 | hold |
| CWM, LLC | 500 | 500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Centerpoint Advisors, LLC | 350 | 350 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Truvestments Capital LLC | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MB, LEVIS & ASSOCIATES, LLC | 1,041 | 1,041 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 18,298 | 18,298 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 15,765 | 15,765 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 133,490 | 133,329 | -161 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 23,971 | 23,110 | -861 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 4,296 | 2,804 | -1,492 | 0.00 | 0.00 | -0.00 | sell |
| Shay Capital LLC | 18,015 | 0 | -18,015 | 0.01 | 0.00 | -0.01 | sell |
| Virtu Financial LLC | 19,574 | 0 | -19,574 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 82,579 | 44,405 | -38,174 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 45,557 | 0 | -45,557 | 0.00 | 0.00 | -0.00 | sell |
| ACORN CAPITAL ADVISORS, LLC | 785,938 | 736,572 | -49,366 | 0.83 | 0.79 | -0.03 | sell |
| CITADEL ADVISORS LLC | 1,100,329 | 1,040,070 | -60,259 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 70,419 | 0 | -70,419 | 0.02 | 0.00 | -0.02 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 141,502 | 64,584 | -76,918 | 0.02 | 0.01 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 115,143 | 10,543 | -104,600 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 217,978 | 0 | -217,978 | 0.04 | 0.00 | -0.04 | sell |
| Exome Asset Management LLC | 462,801 | 208,970 | -253,831 | 0.65 | 0.28 | -0.37 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,394,336 | 0 | -1,394,336 | 0.05 | 0.00 | -0.05 | sell |