| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 1,394,336 | +1,394,336 | 0.00 | 0.05 | +0.05 | buy |
| Cormorant Asset Management, LP | 0 | 1,394,336 | +1,394,336 | 0.00 | 0.16 | +0.16 | buy |
| CITADEL ADVISORS LLC | 0 | 1,181,088 | +1,181,088 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 703,868 | +703,868 | 0.00 | 0.18 | +0.18 | buy |
| Parkman Healthcare Partners LLC | 0 | 696,470 | +696,470 | 0.00 | 0.23 | +0.23 | buy |
| Palo Alto Investors LP | 0 | 445,434 | +445,434 | 0.00 | 0.09 | +0.09 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 118,100 | +118,100 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 27,534 | 94,343 | +66,809 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 60,055 | +60,055 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 36,951 | +36,951 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 25,976 | 46,376 | +20,400 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 17,273 | +17,273 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 10,043 | +10,043 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 44,895 | 49,582 | +4,687 | 0.00 | 0.00 | -0.00 | buy |
| Indiana Trust & Investment Management Co | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 187 | 187 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 22 | 22 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MB, LEVIS & ASSOCIATES, LLC | 1,041 | 1,041 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 4,444 | 4,444 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 11,665 | 11,665 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FEDERATED HERMES, INC. | 127 | 0 | -127 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 75,771 | 0 | -75,771 | 0.00 | 0.00 | -0.00 | sell |