| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 245,800 | +245,800 | 0.00 | 0.02 | +0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 154,134 | +154,134 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,187,413 | 1,230,457 | +43,044 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 36,958 | +36,958 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 443,518 | 475,129 | +31,611 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 25,229 | +25,229 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 21,018 | +21,018 | 0.00 | 0.01 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 168,600 | 176,658 | +8,058 | 0.00 | 0.00 | +0.00 | buy |
| BFSG, LLC | 0 | 3,500 | +3,500 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 134,590 | 135,017 | +427 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 83,069 | 83,314 | +245 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 445,434 | 445,434 | 0 | 0.11 | 0.23 | +0.12 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,394,336 | 1,394,336 | 0 | 0.05 | 0.08 | +0.03 | hold |
| Cormorant Asset Management, LP | 1,394,336 | 1,394,336 | 0 | 0.14 | 0.26 | +0.12 | hold |
| Centerpoint Advisors, LLC | 350 | 350 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Exome Asset Management LLC | 353,434 | 353,434 | 0 | 0.45 | 0.89 | +0.44 | hold |
| MB, LEVIS & ASSOCIATES, LLC | 1,041 | 1,041 | 0 | 0.00 | 0.00 | +0.00 | hold |
| COMMONWEALTH EQUITY SERVICES, LLC | 18,298 | 18,298 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STATE STREET CORP | 15,765 | 15,765 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 100 | 0 | -100 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 187 | 0 | -187 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,209 | 1,386 | -823 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 65,147 | 59,400 | -5,747 | 0.01 | 0.02 | +0.01 | sell |
| NORTHERN TRUST CORP | 37,290 | 23,971 | -13,319 | 0.00 | 0.00 | -0.00 | sell |
| Lynx1 Capital Management LP | 16,194 | 0 | -16,194 | 0.01 | 0.00 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 202,973 | 152,973 | -50,000 | 0.05 | 0.07 | +0.02 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 86,643 | 24,943 | -61,700 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 76,784 | 0 | -76,784 | 0.03 | 0.00 | -0.03 | sell |
| ADAR1 Capital Management, LLC | 152,865 | 0 | -152,865 | 0.05 | 0.00 | -0.05 | sell |