| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GILDER GAGNON HOWE & CO LLC | 2,830,947 | 4,221,516 | +1,390,569 | 0.36 | 0.78 | +0.43 | buy |
| Rock Springs Capital Management LP | 735,000 | 2,110,000 | +1,375,000 | 0.17 | 0.80 | +0.63 | buy |
| First Light Asset Management, LLC | 967,635 | 2,102,554 | +1,134,919 | 0.71 | 2.39 | +1.68 | buy |
| 8 KNOTS MANAGEMENT, LLC | 246,482 | 1,042,049 | +795,567 | 0.42 | 1.59 | +1.17 | buy |
| PFM Health Sciences, LP | 336,166 | 860,821 | +524,655 | 0.18 | 0.60 | +0.42 | buy |
| Rhenman & Partners Asset Management AB | 1,192,054 | 1,691,522 | +499,468 | 1.09 | 2.38 | +1.29 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,765,116 | 1,550,293 | +214,823 | 0.04 | 0.06 | 0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 189,307 | 320,553 | +131,246 | 0.01 | 0.02 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 2,845,000 | 2,951,500 | +106,500 | 0.04 | 0.08 | +0.03 | buy |
| Nebula Research & Development LLC | 10,877 | 83,886 | +73,009 | 0.03 | 0.27 | +0.24 | buy |
| Park West Asset Management LLC | 674,067 | 742,615 | +68,548 | 0.60 | 0.78 | +0.18 | buy |
| Gunderson Capital Management Inc. | 177,833 | 244,299 | +66,466 | 0.93 | 1.69 | +0.76 | buy |
| ARDSLEY ADVISORY PARTNERS LP | 1,332,800 | 1,383,200 | +50,400 | 2.62 | 2.95 | +0.33 | buy |
| GSA CAPITAL PARTNERS LLP | 80,021 | 39,148 | +40,873 | 0.07 | 0.05 | 0.00 | sell |
| NEOS Investment Management LLC | 22,387 | 51,327 | +28,940 | 0.02 | 0.05 | +0.03 | buy |
| Counterpoint Mutual Funds LLC | 25,034 | 48,994 | +23,960 | 0.09 | 0.18 | +0.09 | buy |
| ALGERT GLOBAL LLC | 132,003 | 154,633 | +22,630 | 0.05 | 0.09 | 0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 15,666 | 26,258 | +10,592 | 0.03 | 0.09 | +0.06 | buy |
| Dynamic Technology Lab Private Ltd | 68,325 | 76,081 | +7,756 | 0.07 | 0.12 | +0.05 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 45,047 | 51,780 | +6,733 | 0.42 | 0.04 | -0.38 | buy |
| FNY Investment Advisers, LLC | 1,445 | 3,577 | +2,132 | 0.01 | 0.03 | +0.02 | buy |
| Summit Trail Advisors, LLC | 18,040 | 19,755 | +1,715 | 0.01 | 0.01 | +0.00 | buy |
| SHELL ASSET MANAGEMENT CO | 20,688 | 19,365 | +1,323 | 0.01 | 0.01 | 0.00 | sell |
| DENALI ADVISORS LLC | 240 | 103 | -137 | 0.00 | 0.00 | -0.00 | sell |
| KETTLE HILL CAPITAL MANAGEMENT, LLC | 91,723 | 88,523 | -3,200 | 0.22 | 0.32 | +0.10 | sell |
| Cinctive Capital Management LP | 143,598 | 140,246 | -3,352 | 0.09 | 0.11 | +0.02 | sell |
| LVW Advisors, LLC | 21,009 | 16,849 | -4,160 | 0.04 | 0.04 | +0.01 | sell |
| Cambria Investment Management, L.P. | 46,111 | 39,964 | -6,147 | 0.03 | 0.04 | +0.01 | sell |
| SYMMETRY PEAK MANAGEMENT LLC | 53,298 | 1,000 | -52,298 | 0.12 | 0.00 | -0.11 | sell |
| Watchtower Advisors, LP | 141,096 | 33,120 | -107,976 | 0.87 | 0.27 | -0.59 | sell |
| Hillsdale Investment Management Inc. | 549,000 | 386,900 | -162,100 | 0.41 | 0.46 | +0.05 | sell |
| Iron Triangle Partners LP | 2,052,551 | 1,334,503 | -718,048 | 2.43 | 2.05 | -0.38 | sell |
| Alphabet Inc. | 1,629,087 | 481,988 | -1,147,099 | 0.69 | 0.29 | -0.41 | sell |
| Ancient Art, L.P. | 3,729,904 | 1,988,429 | -1,741,475 | 5.69 | 5.97 | +0.28 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 11,246,820 | 9,373,097 | -1,873,723 | 1.90 | 2.42 | +0.52 | sell |
| SOUTHEASTERN ASSET MANAGEMENT INC/TN/ | 5,718,273 | 3,071,452 | -2,646,821 | 2.01 | 1.75 | -0.26 | sell |