| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 14,244,912 | 14,582,762 | +337,850 | 0.00 | 0.00 | +0.00 | buy |
| Dragoneer Investment Group, LLC | 12,725,999 | 12,725,999 | 0 | 2.53 | 4.38 | +1.85 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 11,246,820 | 9,373,097 | -1,873,723 | 1.90 | 2.42 | +0.52 | sell |
| T. Rowe Price Investment Management, Inc. | 0 | 8,542,846 | +8,542,846 | 0.00 | 0.08 | +0.08 | buy |
| Thrive Capital Management, LLC | 4,755,222 | 4,755,222 | 0 | 8.98 | 10.03 | +1.05 | hold |
| VIKING GLOBAL INVESTORS LP | 0 | 4,732,002 | +4,732,002 | 0.00 | 0.26 | +0.26 | buy |
| STATE STREET CORP | 3,474,181 | 4,654,596 | +1,180,415 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 2,830,947 | 4,221,516 | +1,390,569 | 0.36 | 0.78 | +0.43 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,568,992 | 3,978,152 | +2,409,160 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,207,569 | 3,367,530 | +159,961 | 0.00 | 0.00 | +0.00 | buy |
| SOUTHEASTERN ASSET MANAGEMENT INC/TN/ | 5,718,273 | 3,071,452 | -2,646,821 | 2.01 | 1.75 | -0.26 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,867,885 | 2,981,778 | -886,107 | 0.03 | 0.04 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 2,845,000 | 2,951,500 | +106,500 | 0.04 | 0.07 | +0.03 | buy |
| DIMENSIONAL FUND ADVISORS LP | 3,162,935 | 2,862,859 | -300,076 | 0.01 | 0.01 | +0.00 | sell |
| Capital World Investors | 2,751,000 | 2,751,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| MORGAN STANLEY | 1,760,384 | 2,568,921 | +808,537 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 735,000 | 2,110,000 | +1,375,000 | 0.17 | 0.80 | +0.63 | buy |
| General Catalyst Group Management, LLC | 2,107,719 | 2,107,719 | 0 | 1.52 | 2.41 | +0.90 | hold |
| First Light Asset Management, LLC | 967,635 | 2,102,554 | +1,134,919 | 0.71 | 2.39 | +1.68 | buy |
| Ancient Art, L.P. | 3,729,904 | 1,988,429 | -1,741,475 | 5.69 | 5.97 | +0.28 | sell |
| GLYNN CAPITAL MANAGEMENT LLC | 1,915,719 | 1,915,719 | 0 | 3.28 | 5.34 | +2.06 | hold |
| PRUDENTIAL FINANCIAL INC | 304,412 | 1,881,231 | +1,576,819 | 0.00 | 0.04 | +0.04 | buy |
| JPMORGAN CHASE & CO | 583,368 | 1,859,906 | +1,276,538 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 1,192,054 | 1,691,522 | +499,468 | 1.09 | 2.38 | +1.29 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,765,116 | 1,550,293 | -214,823 | 0.04 | 0.06 | +0.02 | sell |
| Assenagon Asset Management S.A. | 732,285 | 1,539,037 | +806,752 | 0.02 | 0.06 | +0.04 | buy |
| TWO SIGMA ADVISERS, LP | 1,840,400 | 1,513,600 | -326,800 | 0.04 | 0.05 | +0.01 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 518,393 | 1,476,961 | +958,568 | 0.02 | 0.08 | +0.06 | buy |
| NORTHERN TRUST CORP | 1,438,214 | 1,413,207 | -25,007 | 0.00 | 0.00 | +0.00 | sell |
| ARDSLEY ADVISORY PARTNERS LP | 1,332,800 | 1,383,200 | +50,400 | 2.62 | 2.95 | +0.33 | buy |
| Iron Triangle Partners LP | 2,052,551 | 1,334,503 | -718,048 | 2.43 | 2.05 | -0.38 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,160,483 | 1,193,887 | +33,404 | 0.00 | 0.00 | +0.00 | buy |
| 8 KNOTS MANAGEMENT, LLC | 246,482 | 1,042,049 | +795,567 | 0.42 | 1.59 | +1.17 | buy |
| GOLDMAN SACHS GROUP INC | 420,333 | 975,016 | +554,683 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 336,166 | 860,821 | +524,655 | 0.18 | 0.64 | +0.45 | buy |
| Parkman Healthcare Partners LLC | 0 | 831,283 | +831,283 | 0.00 | 1.52 | +1.52 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 825,231 | +825,231 | 0.00 | 0.12 | +0.12 | buy |
| BAILLIE GIFFORD & CO | 822,088 | 822,088 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Cubist Systematic Strategies, LLC | 654,379 | 804,740 | +150,361 | 0.07 | 0.14 | +0.06 | buy |
| CITADEL ADVISORS LLC | 2,889,273 | 748,555 | -2,140,718 | 0.03 | 0.01 | -0.02 | sell |
| Park West Asset Management LLC | 674,067 | 742,615 | +68,548 | 0.60 | 0.83 | +0.22 | buy |
| Holocene Advisors, LP | 0 | 738,812 | +738,812 | 0.00 | 0.04 | +0.04 | buy |
| Beck Bode, LLC | 0 | 662,837 | +662,837 | 0.00 | 2.01 | +2.01 | buy |
| UBS Group AG | 1,148,610 | 643,558 | -505,052 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 100,822 | 642,567 | +541,745 | 0.00 | 0.02 | +0.02 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 625,123 | +625,123 | 0.00 | 0.07 | +0.07 | buy |
| FIRST TRUST ADVISORS LP | 434,878 | 594,859 | +159,981 | 0.00 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 637,088 | 532,822 | -104,266 | 0.00 | 0.00 | +0.00 | sell |
| Trexquant Investment LP | 0 | 529,541 | +529,541 | 0.00 | 0.16 | +0.16 | buy |
| Integral Health Asset Management, LLC | 0 | 500,000 | +500,000 | 0.00 | 0.73 | +0.73 | buy |
| TD ASSET MANAGEMENT INC | 195,600 | 492,800 | +297,200 | 0.00 | 0.01 | +0.01 | buy |
| Alphabet Inc. | 1,629,087 | 481,988 | -1,147,099 | 0.69 | 0.29 | -0.41 | sell |
| BANK OF AMERICA CORP /DE/ | 326,369 | 480,407 | +154,038 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 449,604 | 449,604 | 0 | 0.26 | 0.38 | +0.12 | hold |
| AMERIPRISE FINANCIAL INC | 0 | 400,177 | +400,177 | 0.00 | 0.00 | +0.00 | buy |
| Hillsdale Investment Management Inc. | 549,000 | 386,900 | -162,100 | 0.41 | 0.46 | +0.05 | sell |
| TUDOR INVESTMENT CORP ET AL | 0 | 378,424 | +378,424 | 0.00 | 0.07 | +0.07 | buy |
| FRED ALGER MANAGEMENT, LLC | 189,307 | 320,553 | +131,246 | 0.01 | 0.02 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 157,470 | 311,832 | +154,362 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 583,573 | 306,991 | -276,582 | 0.01 | 0.01 | -0.00 | sell |
| JANE STREET GROUP, LLC | 116,028 | 297,027 | +180,999 | 0.00 | 0.01 | +0.00 | buy |
| FEDERATED HERMES, INC. | 295,687 | 295,875 | +188 | 0.01 | 0.01 | +0.00 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 0 | 295,000 | +295,000 | 0.00 | 0.32 | +0.32 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 276,873 | +276,873 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 257,700 | 263,800 | +6,100 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 177,831 | 256,375 | +78,544 | 0.00 | 0.00 | +0.00 | buy |
| Atika Capital Management LLC | 0 | 254,232 | +254,232 | 0.00 | 0.42 | +0.42 | buy |
| BOSUN ASSET MANAGEMENT, LLC | 0 | 248,820 | +248,820 | 0.00 | 2.11 | +2.11 | buy |
| RHUMBLINE ADVISERS | 241,817 | 248,624 | +6,807 | 0.00 | 0.00 | +0.00 | buy |
| Gunderson Capital Management Inc. | 177,833 | 244,299 | +66,466 | 0.93 | 1.69 | +0.76 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 236,400 | +236,400 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 221,920 | 221,272 | -648 | 0.01 | 0.02 | +0.01 | sell |
| Invesco Ltd. | 532,872 | 203,575 | -329,297 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 286,968 | 198,889 | -88,079 | 0.07 | 0.08 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 276,022 | 189,402 | -86,620 | 0.00 | 0.00 | +0.00 | sell |
| 12 West Capital Management LP | 0 | 186,855 | +186,855 | 0.00 | 0.25 | +0.25 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 144,273 | 175,050 | +30,777 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 166,455 | +166,455 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 132,003 | 154,633 | +22,630 | 0.05 | 0.09 | +0.04 | buy |
| BARCLAYS PLC | 337,636 | 153,906 | -183,730 | 0.00 | 0.00 | -0.00 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 150,000 | +150,000 | 0.00 | 0.01 | +0.01 | buy |
| Concentric Capital Strategies, LP | 0 | 149,130 | +149,130 | 0.00 | 0.14 | +0.14 | buy |
| BIT Capital GmbH | 0 | 147,186 | +147,186 | 0.00 | 0.19 | +0.19 | buy |
| Legal & General Group Plc | 114,041 | 140,261 | +26,220 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 143,598 | 140,246 | -3,352 | 0.09 | 0.11 | +0.02 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 142,415 | 136,350 | -6,065 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 257,222 | 128,531 | -128,691 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 132,713 | 110,660 | -22,053 | 0.00 | 0.01 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 35,867 | 98,321 | +62,454 | 0.00 | 0.00 | +0.00 | buy |
| KETTLE HILL CAPITAL MANAGEMENT, LLC | 91,723 | 88,523 | -3,200 | 0.22 | 0.32 | +0.10 | sell |
| Quadrature Capital Ltd | 0 | 88,210 | +88,210 | 0.00 | 0.02 | +0.02 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 44,383 | 84,211 | +39,828 | 0.00 | 0.01 | +0.01 | buy |
| Nebula Research & Development LLC | 10,877 | 83,886 | +73,009 | 0.03 | 0.27 | +0.24 | buy |
| MetLife Investment Management, LLC | 82,216 | 82,216 | 0 | 0.01 | 0.01 | +0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 78,402 | 79,411 | +1,009 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 59,406 | 77,880 | +18,474 | 0.00 | 0.00 | +0.00 | buy |
| PineBridge Investments, L.P. | 0 | 77,263 | +77,263 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 72,296 | 76,403 | +4,107 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 68,325 | 76,081 | +7,756 | 0.07 | 0.12 | +0.05 | buy |
| Verition Fund Management LLC | 16,933 | 74,427 | +57,494 | 0.00 | 0.01 | +0.01 | buy |