| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 14,582,762 | 17,384,671 | +2,801,909 | 0.00 | 0.01 | +0.00 | buy |
| Dragoneer Investment Group, LLC | 12,725,999 | 12,725,999 | 0 | 4.38 | 3.85 | -0.54 | hold |
| T. Rowe Price Investment Management, Inc. | 8,542,846 | 11,285,595 | +2,742,749 | 0.08 | 0.11 | +0.03 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 9,373,097 | 6,959,787 | -2,413,310 | 2.42 | 1.83 | -0.59 | sell |
| VIKING GLOBAL INVESTORS LP | 4,732,002 | 5,928,038 | +1,196,036 | 0.26 | 0.36 | +0.10 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,978,152 | 4,956,435 | +978,283 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 4,654,596 | 4,841,467 | +186,871 | 0.00 | 0.00 | +0.00 | buy |
| Thrive Capital Management, LLC | 4,755,222 | 4,755,222 | 0 | 10.03 | 8.82 | -1.21 | hold |
| GILDER GAGNON HOWE & CO LLC | 4,221,516 | 4,734,738 | +513,222 | 0.78 | 0.94 | +0.15 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 2,951,500 | 3,886,100 | +934,600 | 0.07 | 0.10 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,367,530 | 3,884,435 | +516,905 | 0.00 | 0.01 | +0.00 | buy |
| Capital World Investors | 2,751,000 | 2,751,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 2,862,859 | 2,653,701 | -209,158 | 0.01 | 0.01 | -0.00 | sell |
| SOUTHEASTERN ASSET MANAGEMENT INC/TN/ | 3,071,452 | 2,401,192 | -670,260 | 1.75 | 1.65 | -0.10 | sell |
| General Catalyst Group Management, LLC | 2,107,719 | 2,107,719 | 0 | 2.41 | 2.87 | +0.46 | hold |
| Assenagon Asset Management S.A. | 1,539,037 | 2,046,046 | +507,009 | 0.06 | 0.08 | +0.02 | buy |
| GLYNN CAPITAL MANAGEMENT LLC | 1,915,719 | 1,915,719 | 0 | 5.34 | 6.12 | +0.78 | hold |
| Rhenman & Partners Asset Management AB | 1,691,522 | 1,906,611 | +215,089 | 2.38 | 2.90 | +0.51 | buy |
| First Light Asset Management, LLC | 2,102,554 | 1,865,922 | -236,632 | 2.39 | 2.59 | +0.19 | sell |
| Iron Triangle Partners LP | 1,334,503 | 1,832,256 | +497,753 | 2.05 | 3.04 | +0.98 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,550,293 | 1,698,200 | +147,907 | 0.06 | 0.06 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,981,778 | 1,650,544 | -1,331,234 | 0.04 | 0.02 | -0.02 | sell |
| Capital International Investors | 0 | 1,624,234 | +1,624,234 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 2,568,921 | 1,615,089 | -953,832 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 1,881,231 | 1,527,972 | -353,259 | 0.04 | 0.04 | -0.00 | sell |
| Holocene Advisors, LP | 738,812 | 1,438,820 | +700,008 | 0.04 | 0.10 | +0.05 | buy |
| Bank of New York Mellon Corp | 532,822 | 1,393,048 | +860,226 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 1,413,207 | 1,382,884 | -30,323 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 1,859,906 | 1,370,408 | -489,498 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,193,887 | 1,329,943 | +136,056 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 1,513,600 | 1,313,500 | -200,100 | 0.05 | 0.05 | -0.01 | sell |
| ARDSLEY ADVISORY PARTNERS LP | 1,383,200 | 1,281,300 | -101,900 | 2.95 | 3.72 | +0.77 | sell |
| Rock Springs Capital Management LP | 2,110,000 | 1,251,500 | -858,500 | 0.80 | 0.60 | -0.20 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 1,236,584 | +1,236,584 | 0.00 | 0.08 | +0.08 | buy |
| Trexquant Investment LP | 529,541 | 1,215,989 | +686,448 | 0.16 | 0.29 | +0.14 | buy |
| CITADEL ADVISORS LLC | 748,555 | 1,191,464 | +442,909 | 0.01 | 0.02 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 825,231 | 1,182,834 | +357,603 | 0.12 | 0.18 | +0.06 | buy |
| Ancient Art, L.P. | 1,988,429 | 1,074,012 | -914,417 | 5.97 | 4.35 | -1.62 | sell |
| GOLDMAN SACHS GROUP INC | 975,016 | 1,063,047 | +88,031 | 0.00 | 0.00 | +0.00 | buy |
| 8 KNOTS MANAGEMENT, LLC | 1,042,049 | 1,042,049 | 0 | 1.59 | 1.59 | 0.00 | hold |
| Man Group plc | 0 | 937,407 | +937,407 | 0.00 | 0.04 | +0.04 | buy |
| Point72 Asset Management, L.P. | 0 | 930,238 | +930,238 | 0.00 | 0.05 | +0.05 | buy |
| Invesco Ltd. | 203,575 | 880,740 | +677,165 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 860,821 | 860,821 | 0 | 0.64 | 0.74 | +0.11 | hold |
| Qube Research & Technologies Ltd | 642,567 | 842,501 | +199,934 | 0.02 | 0.02 | +0.01 | buy |
| BAILLIE GIFFORD & CO | 822,088 | 822,088 | 0 | 0.01 | 0.01 | +0.00 | hold |
| COOKSON PEIRCE & CO INC | 0 | 735,808 | +735,808 | 0.00 | 0.56 | +0.56 | buy |
| Park West Asset Management LLC | 742,615 | 677,615 | -65,000 | 0.83 | 0.84 | +0.01 | sell |
| TD ASSET MANAGEMENT INC | 492,800 | 669,684 | +176,884 | 0.01 | 0.01 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 804,740 | 661,939 | -142,801 | 0.14 | 0.18 | +0.04 | sell |
| UBS Group AG | 643,558 | 616,658 | -26,900 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 589,702 | +589,702 | 0.00 | 0.01 | +0.01 | buy |
| HENNESSY ADVISORS INC | 0 | 571,900 | +571,900 | 0.00 | 0.34 | +0.34 | buy |
| Beck Bode, LLC | 662,837 | 564,297 | -98,540 | 2.01 | 1.79 | -0.22 | sell |
| JUPITER ASSET MANAGEMENT LTD | 43,928 | 562,049 | +518,121 | 0.01 | 0.08 | +0.08 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,476,961 | 560,874 | -916,087 | 0.08 | 0.03 | -0.05 | sell |
| Integral Health Asset Management, LLC | 500,000 | 500,000 | 0 | 0.73 | 0.79 | +0.06 | hold |
| Alphabet Inc. | 481,988 | 481,988 | 0 | 0.29 | 0.39 | +0.10 | hold |
| BANK OF AMERICA CORP /DE/ | 480,407 | 454,348 | -26,059 | 0.00 | 0.00 | -0.00 | sell |
| RBF Capital, LLC | 449,604 | 449,604 | 0 | 0.38 | 0.41 | +0.04 | hold |
| FIRST TRUST ADVISORS LP | 594,859 | 412,283 | -182,576 | 0.01 | 0.01 | -0.00 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 295,000 | 407,500 | +112,500 | 0.32 | 0.40 | +0.08 | buy |
| TWINBEECH CAPITAL LP | 0 | 406,811 | +406,811 | 0.00 | 0.13 | +0.13 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 150,000 | 383,700 | +233,700 | 0.01 | 0.02 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 256,375 | 329,129 | +72,754 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 297,027 | 318,983 | +21,956 | 0.01 | 0.01 | -0.00 | buy |
| Eversept Partners, LP | 0 | 310,893 | +310,893 | 0.00 | 0.38 | +0.38 | buy |
| Hillsdale Investment Management Inc. | 386,900 | 296,560 | -90,340 | 0.46 | 0.37 | -0.09 | sell |
| Engineers Gate Manager LP | 198,889 | 296,371 | +97,482 | 0.08 | 0.11 | +0.03 | buy |
| AGF MANAGEMENT LTD | 0 | 282,660 | +282,660 | 0.00 | 0.02 | +0.02 | buy |
| FEDERATED HERMES, INC. | 295,875 | 281,842 | -14,033 | 0.01 | 0.01 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 175,050 | 273,690 | +98,640 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 248,624 | 270,341 | +21,717 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 263,800 | 267,400 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 221,272 | 254,780 | +33,508 | 0.02 | 0.02 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 320,553 | 253,884 | -66,669 | 0.02 | 0.02 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 0 | 244,048 | +244,048 | 0.00 | 0.00 | +0.00 | buy |
| Gunderson Capital Management Inc. | 244,299 | 243,362 | -937 | 1.69 | 1.65 | -0.03 | sell |
| ALLIANCEBERNSTEIN L.P. | 311,832 | 240,560 | -71,272 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 26,747 | 228,501 | +201,754 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 154,633 | 226,339 | +71,706 | 0.09 | 0.12 | +0.03 | buy |
| BOSUN ASSET MANAGEMENT, LLC | 248,820 | 225,446 | -23,374 | 2.11 | 2.14 | +0.03 | sell |
| Global IMC LLC | 0 | 210,065 | +210,065 | 0.00 | 0.75 | +0.75 | buy |
| SG Americas Securities, LLC | 18,992 | 190,039 | +171,047 | 0.00 | 0.02 | +0.02 | buy |
| D L CARLSON INVESTMENT GROUP INC | 0 | 188,348 | +188,348 | 0.00 | 0.58 | +0.58 | buy |
| 12 West Capital Management LP | 186,855 | 186,855 | 0 | 0.25 | 0.30 | +0.05 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 236,400 | 157,000 | -79,400 | 0.00 | 0.00 | -0.00 | sell |
| Informed Momentum Co LLC | 0 | 155,194 | +155,194 | 0.00 | 0.40 | +0.40 | buy |
| SEI INVESTMENTS CO | 42,998 | 155,010 | +112,012 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 147,186 | 154,225 | +7,039 | 0.19 | 0.22 | +0.03 | buy |
| Graham Capital Management, L.P. | 0 | 154,144 | +154,144 | 0.00 | 0.08 | +0.08 | buy |
| AQR CAPITAL MANAGEMENT LLC | 98,321 | 152,630 | +54,309 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 140,261 | 152,614 | +12,353 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 151,230 | +151,230 | 0.00 | 0.47 | +0.47 | buy |
| Squarepoint Ops LLC | 110,660 | 142,650 | +31,990 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 136,350 | 136,933 | +583 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 0 | 132,637 | +132,637 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 4,463 | 129,451 | +124,988 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 39,148 | 116,431 | +77,283 | 0.05 | 0.13 | +0.08 | buy |
| Nebula Research & Development LLC | 83,886 | 115,506 | +31,620 | 0.27 | 0.30 | +0.03 | buy |