| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 17,384,671 | 18,411,347 | +1,026,676 | 0.01 | 0.01 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 11,285,595 | 11,661,066 | +375,471 | 0.11 | 0.15 | +0.04 | buy |
| Dragoneer Investment Group, LLC | 12,725,999 | 9,487,894 | -3,238,105 | 3.85 | 3.50 | -0.35 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 6,959,787 | 7,851,675 | +891,888 | 1.83 | 2.49 | +0.66 | buy |
| VIKING GLOBAL INVESTORS LP | 5,928,038 | 6,172,132 | +244,094 | 0.36 | 0.48 | +0.12 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,956,435 | 5,388,061 | +431,626 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 4,841,467 | 5,132,802 | +291,335 | 0.00 | 0.00 | +0.00 | buy |
| Thrive Capital Management, LLC | 4,755,222 | 4,755,222 | 0 | 8.82 | 10.05 | +1.23 | hold |
| CITADEL ADVISORS LLC | 1,191,464 | 4,468,248 | +3,276,784 | 0.02 | 0.10 | +0.08 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,884,435 | 4,339,640 | +455,205 | 0.01 | 0.01 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 4,734,738 | 4,184,606 | -550,132 | 0.94 | 1.06 | +0.12 | sell |
| Capital World Investors | 2,751,000 | 3,622,586 | +871,586 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 3,886,100 | 3,564,100 | -322,000 | 0.10 | 0.11 | +0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 2,653,701 | 3,135,476 | +481,775 | 0.01 | 0.02 | +0.01 | buy |
| JPMORGAN CHASE & CO | 1,370,408 | 2,309,150 | +938,742 | 0.00 | 0.00 | +0.00 | buy |
| General Catalyst Group Management, LLC | 2,107,719 | 2,107,719 | 0 | 2.87 | 3.12 | +0.25 | hold |
| SOUTHEASTERN ASSET MANAGEMENT INC/TN/ | 2,401,192 | 2,057,725 | -343,467 | 1.65 | 2.06 | +0.40 | sell |
| GLYNN CAPITAL MANAGEMENT LLC | 1,915,719 | 1,915,719 | 0 | 6.12 | 9.30 | +3.19 | hold |
| NORTHERN TRUST CORP | 1,382,884 | 1,773,673 | +390,789 | 0.00 | 0.01 | +0.00 | buy |
| Ancient Art, L.P. | 1,074,012 | 1,768,619 | +694,607 | 4.35 | 8.68 | +4.33 | buy |
| First Light Asset Management, LLC | 1,865,922 | 1,765,892 | -100,030 | 2.59 | 3.12 | +0.53 | sell |
| Capital International Investors | 1,624,234 | 1,624,234 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Iron Triangle Partners LP | 1,832,256 | 1,611,909 | -220,347 | 3.04 | 4.81 | +1.77 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,329,943 | 1,600,166 | +270,223 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 1,615,089 | 1,541,947 | -73,142 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 1,698,200 | 1,525,773 | -172,427 | 0.06 | 0.07 | +0.01 | sell |
| Bank of New York Mellon Corp | 1,393,048 | 1,478,606 | +85,558 | 0.00 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,650,544 | 1,476,892 | -173,652 | 0.02 | 0.03 | +0.01 | sell |
| Rhenman & Partners Asset Management AB | 1,906,611 | 1,371,147 | -535,464 | 2.90 | 2.36 | -0.54 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,182,834 | 1,367,000 | +184,166 | 0.18 | 0.25 | +0.07 | buy |
| Qube Research & Technologies Ltd | 842,501 | 1,294,337 | +451,836 | 0.02 | 0.05 | +0.03 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 1,294,280 | +1,294,280 | 0.00 | 0.12 | +0.12 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,236,584 | 1,263,672 | +27,088 | 0.08 | 0.10 | +0.02 | buy |
| Point72 Asset Management, L.P. | 930,238 | 1,212,096 | +281,858 | 0.05 | 0.09 | +0.04 | buy |
| TWO SIGMA ADVISERS, LP | 1,313,500 | 1,175,100 | -138,400 | 0.05 | 0.06 | +0.01 | sell |
| ARDSLEY ADVISORY PARTNERS LP | 1,281,300 | 1,102,600 | -178,700 | 3.72 | 4.43 | +0.70 | sell |
| Rock Springs Capital Management LP | 1,251,500 | 1,011,400 | -240,100 | 0.60 | 0.70 | +0.10 | sell |
| Cubist Systematic Strategies, LLC | 661,939 | 999,820 | +337,881 | 0.18 | 0.32 | +0.14 | buy |
| Assenagon Asset Management S.A. | 2,046,046 | 973,791 | -1,072,255 | 0.08 | 0.04 | -0.04 | sell |
| GOLDMAN SACHS GROUP INC | 1,063,047 | 917,048 | -145,999 | 0.00 | 0.00 | +0.00 | sell |
| PFM Health Sciences, LP | 860,821 | 860,821 | 0 | 0.74 | 1.05 | +0.31 | hold |
| JUPITER ASSET MANAGEMENT LTD | 562,049 | 841,445 | +279,396 | 0.08 | 0.16 | +0.07 | buy |
| BAILLIE GIFFORD & CO | 822,088 | 822,088 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Invesco Ltd. | 880,740 | 811,571 | -69,169 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 616,658 | 752,844 | +136,186 | 0.00 | 0.00 | +0.00 | buy |
| COOKSON PEIRCE & CO INC | 735,808 | 746,241 | +10,433 | 0.56 | 0.74 | +0.18 | buy |
| Holocene Advisors, LP | 1,438,820 | 727,568 | -711,252 | 0.10 | 0.06 | -0.03 | sell |
| TD ASSET MANAGEMENT INC | 669,684 | 717,536 | +47,852 | 0.01 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 1,215,989 | 657,978 | -558,011 | 0.29 | 0.18 | -0.12 | sell |
| 8 KNOTS MANAGEMENT, LLC | 1,042,049 | 650,607 | -391,442 | 1.59 | 1.63 | +0.04 | sell |
| HENNESSY ADVISORS INC | 571,900 | 644,100 | +72,200 | 0.34 | 0.44 | +0.10 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 600,000 | +600,000 | 0.00 | 0.25 | +0.25 | buy |
| OBERWEIS ASSET MANAGEMENT INC/ | 407,500 | 576,850 | +169,350 | 0.40 | 0.63 | +0.23 | buy |
| FIRST TRUST ADVISORS LP | 412,283 | 555,216 | +142,933 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 49,708 | 492,695 | +442,987 | 0.01 | 0.08 | +0.08 | buy |
| Alphabet Inc. | 481,988 | 481,988 | 0 | 0.39 | 0.55 | +0.17 | hold |
| AMERICAN CENTURY COMPANIES INC | 49,725 | 450,060 | +400,335 | 0.00 | 0.01 | +0.01 | buy |
| RBF Capital, LLC | 449,604 | 449,604 | 0 | 0.41 | 0.49 | +0.07 | hold |
| BANK OF AMERICA CORP /DE/ | 454,348 | 446,669 | -7,679 | 0.00 | 0.00 | +0.00 | sell |
| BRIDGER MANAGEMENT, LLC | 95,700 | 413,800 | +318,100 | 0.78 | 4.39 | +3.61 | buy |
| Man Group plc | 937,407 | 407,662 | -529,745 | 0.04 | 0.02 | -0.01 | sell |
| AGF MANAGEMENT LTD | 282,660 | 372,603 | +89,943 | 0.02 | 0.04 | +0.02 | buy |
| ALGERT GLOBAL LLC | 226,339 | 369,685 | +143,346 | 0.12 | 0.21 | +0.09 | buy |
| Jump Financial, LLC | 38,775 | 357,391 | +318,616 | 0.01 | 0.16 | +0.14 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 273,690 | 353,491 | +79,801 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 329,129 | 353,072 | +23,943 | 0.00 | 0.01 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 351,618 | +351,618 | 0.00 | 0.14 | +0.14 | buy |
| Engineers Gate Manager LP | 296,371 | 348,231 | +51,860 | 0.11 | 0.14 | +0.04 | buy |
| MARSHALL WACE, LLP | 589,702 | 342,738 | -246,964 | 0.01 | 0.01 | -0.00 | sell |
| Atika Capital Management LLC | 0 | 333,000 | +333,000 | 0.00 | 0.76 | +0.76 | buy |
| PRUDENTIAL FINANCIAL INC | 1,527,972 | 330,710 | -1,197,262 | 0.04 | 0.01 | -0.03 | sell |
| BARCLAYS PLC | 102,629 | 325,818 | +223,189 | 0.00 | 0.00 | +0.00 | buy |
| Park West Asset Management LLC | 677,615 | 322,415 | -355,200 | 0.84 | 0.51 | -0.33 | sell |
| Swiss National Bank | 267,400 | 314,900 | +47,500 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 112,790 | 306,472 | +193,682 | 0.00 | 0.01 | +0.01 | buy |
| Hillsdale Investment Management Inc. | 296,560 | 296,660 | +100 | 0.37 | 0.48 | +0.12 | buy |
| HAWK RIDGE CAPITAL MANAGEMENT LP | 0 | 276,482 | +276,482 | 0.00 | 0.25 | +0.25 | buy |
| TWINBEECH CAPITAL LP | 406,811 | 266,685 | -140,126 | 0.13 | 0.11 | -0.02 | sell |
| RHUMBLINE ADVISERS | 270,341 | 264,744 | -5,597 | 0.00 | 0.01 | +0.00 | sell |
| BOSUN ASSET MANAGEMENT, LLC | 225,446 | 262,563 | +37,117 | 2.14 | 2.68 | +0.55 | buy |
| Parkman Healthcare Partners LLC | 0 | 250,000 | +250,000 | 0.00 | 0.68 | +0.68 | buy |
| Gunderson Capital Management Inc. | 243,362 | 248,491 | +5,129 | 1.65 | 2.23 | +0.58 | buy |
| ALLIANCEBERNSTEIN L.P. | 240,560 | 240,560 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PANAGORA ASSET MANAGEMENT INC | 254,780 | 237,550 | -17,230 | 0.02 | 0.02 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 64,773 | 232,338 | +167,565 | 0.00 | 0.01 | +0.00 | buy |
| General Equity Holdings LP | 0 | 230,000 | +230,000 | 0.00 | 3.39 | +3.39 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 194,344 | 208,933 | +14,589 | 0.01 | 0.01 | +0.00 | buy |
| Amundi | 0 | 207,870 | +207,870 | 0.00 | 0.00 | +0.00 | buy |
| 12 West Capital Management LP | 186,855 | 186,855 | 0 | 0.30 | 0.41 | +0.10 | hold |
| D L CARLSON INVESTMENT GROUP INC | 188,348 | 185,224 | -3,124 | 0.58 | 0.71 | +0.14 | sell |
| FRED ALGER MANAGEMENT, LLC | 253,884 | 183,828 | -70,056 | 0.02 | 0.02 | -0.00 | sell |
| Legal & General Group Plc | 152,614 | 182,727 | +30,113 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 281,842 | 174,756 | -107,086 | 0.01 | 0.01 | -0.00 | sell |
| Verition Fund Management LLC | 0 | 171,755 | +171,755 | 0.00 | 0.02 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 152,630 | 164,269 | +11,639 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 228,501 | 163,340 | -65,161 | 0.01 | 0.01 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 157,000 | 157,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 136,933 | 155,055 | +18,122 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 132,637 | 151,589 | +18,952 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 101,326 | 148,663 | +47,337 | 0.00 | 0.00 | +0.00 | buy |