| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 18,411,347 | 18,997,973 | +586,626 | 0.01 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 15,466,253 | 16,219,461 | +753,208 | 0.01 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 7,851,675 | 11,835,000 | +3,983,325 | 2.49 | 3.03 | +0.54 | buy |
| T. Rowe Price Investment Management, Inc. | 11,661,066 | 11,358,944 | -302,122 | 0.15 | 0.09 | -0.05 | sell |
| JPMORGAN CHASE & CO | 2,309,150 | 10,360,529 | +8,051,379 | 0.00 | 0.01 | +0.01 | buy |
| Dragoneer Investment Group, LLC | 9,487,894 | 9,487,894 | 0 | 3.50 | 2.23 | -1.27 | hold |
| Thrive Capital Management, LLC | 4,755,222 | 6,343,617 | +1,588,395 | 10.05 | 14.58 | +4.53 | buy |
| GILDER GAGNON HOWE & CO LLC | 4,184,606 | 6,335,862 | +2,151,256 | 1.06 | 0.92 | -0.14 | buy |
| STATE STREET CORP | 5,132,802 | 5,916,371 | +783,569 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,388,061 | 4,744,902 | -643,159 | 0.01 | 0.01 | -0.01 | sell |
| BIT Capital GmbH | 76,981 | 4,473,853 | +4,396,872 | 0.16 | 5.26 | +5.11 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 4,339,640 | 4,468,098 | +128,458 | 0.01 | 0.00 | -0.00 | buy |
| HENNESSY ADVISORS INC | 644,100 | 4,188,400 | +3,544,300 | 0.44 | 1.67 | +1.24 | buy |
| Capital World Investors | 3,622,586 | 3,622,586 | 0 | 0.01 | 0.01 | -0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 3,135,476 | 3,448,703 | +313,227 | 0.02 | 0.01 | -0.00 | buy |
| SOUTHEASTERN ASSET MANAGEMENT INC/TN/ | 2,057,725 | 3,131,084 | +1,073,359 | 2.06 | 1.99 | -0.07 | buy |
| VIKING GLOBAL INVESTORS LP | 6,172,132 | 3,073,765 | -3,098,367 | 0.48 | 0.13 | -0.34 | sell |
| Ancient Art, L.P. | 1,768,619 | 2,950,753 | +1,182,134 | 8.68 | 8.44 | -0.25 | buy |
| GLYNN CAPITAL MANAGEMENT LLC | 1,915,719 | 2,733,237 | +817,518 | 9.30 | 8.66 | -0.64 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 3,564,100 | 2,677,673 | -886,427 | 0.11 | 0.05 | -0.06 | sell |
| General Catalyst Group Management, LLC | 2,107,719 | 2,107,719 | 0 | 3.12 | 2.48 | -0.64 | hold |
| MILLENNIUM MANAGEMENT LLC | 1,476,892 | 2,011,171 | +534,279 | 0.03 | 0.02 | -0.00 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,294,280 | 1,998,770 | +704,490 | 0.12 | 0.12 | -0.01 | buy |
| NORTHERN TRUST CORP | 1,773,673 | 1,947,779 | +174,106 | 0.01 | 0.00 | -0.00 | buy |
| Man Group plc | 407,662 | 1,813,216 | +1,405,554 | 0.02 | 0.07 | +0.05 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,263,672 | 1,741,306 | +477,634 | 0.10 | 0.08 | -0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,600,166 | 1,654,862 | +54,696 | 0.01 | 0.00 | -0.00 | buy |
| Capital International Investors | 1,624,234 | 1,624,234 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Clearbridge Investments, LLC | 0 | 1,420,208 | +1,420,208 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 1,478,606 | 1,375,408 | -103,198 | 0.01 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 1,371,147 | 1,362,421 | -8,726 | 2.36 | 1.88 | -0.48 | sell |
| AMERICAN CENTURY COMPANIES INC | 450,060 | 1,285,204 | +835,144 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 752,844 | 1,200,007 | +447,163 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 917,048 | 1,172,540 | +255,492 | 0.00 | 0.00 | -0.00 | buy |
| MORGAN STANLEY | 1,541,947 | 1,166,187 | -375,760 | 0.00 | 0.00 | -0.00 | sell |
| JUPITER ASSET MANAGEMENT LTD | 841,445 | 1,155,242 | +313,797 | 0.16 | 0.15 | -0.00 | buy |
| Holocene Advisors, LP | 727,568 | 1,125,910 | +398,342 | 0.06 | 0.05 | -0.01 | buy |
| ARDSLEY ADVISORY PARTNERS LP | 1,102,600 | 1,125,000 | +22,400 | 4.43 | 2.93 | -1.50 | buy |
| Rock Springs Capital Management LP | 1,011,400 | 1,050,000 | +38,600 | 0.70 | 0.54 | -0.16 | buy |
| AMERIPRISE FINANCIAL INC | 30,881 | 976,563 | +945,682 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 157,000 | 958,200 | +801,200 | 0.00 | 0.01 | +0.01 | buy |
| Park West Asset Management LLC | 322,415 | 925,000 | +602,585 | 0.51 | 1.03 | +0.53 | buy |
| PFM Health Sciences, LP | 860,821 | 860,821 | 0 | 1.05 | 0.88 | -0.17 | hold |
| BAILLIE GIFFORD & CO | 822,088 | 822,088 | 0 | 0.01 | 0.01 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 717,536 | 722,440 | +4,904 | 0.01 | 0.01 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 1,525,773 | 707,485 | -818,288 | 0.07 | 0.02 | -0.05 | sell |
| Integral Health Asset Management, LLC | 0 | 700,000 | +700,000 | 0.00 | 0.83 | +0.83 | buy |
| Amundi | 207,870 | 690,654 | +482,784 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 1,294,337 | 680,735 | -613,602 | 0.05 | 0.01 | -0.04 | sell |
| OBERWEIS ASSET MANAGEMENT INC/ | 576,850 | 593,850 | +17,000 | 0.63 | 0.38 | -0.25 | buy |
| Aspen Grove Capital, LLC | 0 | 577,027 | +577,027 | 0.00 | 1.64 | +1.64 | buy |
| FMR LLC | 109,002 | 566,109 | +457,107 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 357,391 | 562,376 | +204,985 | 0.16 | 0.16 | +0.00 | buy |
| First Light Asset Management, LLC | 1,765,892 | 546,822 | -1,219,070 | 3.12 | 0.70 | -2.41 | sell |
| Alphabet Inc. | 481,988 | 481,988 | 0 | 0.55 | 0.38 | -0.18 | hold |
| RBF Capital, LLC | 449,604 | 449,604 | 0 | 0.49 | 0.31 | -0.17 | hold |
| Assenagon Asset Management S.A. | 973,791 | 432,714 | -541,077 | 0.04 | 0.01 | -0.03 | sell |
| CITADEL ADVISORS LLC | 4,468,248 | 428,611 | -4,039,637 | 0.10 | 0.01 | -0.09 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 421,993 | +421,993 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 325,818 | 361,062 | +35,244 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 353,072 | 355,832 | +2,760 | 0.01 | 0.00 | -0.00 | buy |
| GDS Wealth Management | 21,019 | 345,817 | +324,798 | 0.04 | 0.42 | +0.38 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 353,491 | 338,441 | -15,050 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 314,900 | 324,800 | +9,900 | 0.00 | 0.00 | -0.00 | buy |
| Atika Capital Management LLC | 333,000 | 322,300 | -10,700 | 0.76 | 0.56 | -0.19 | sell |
| FIRST TRUST ADVISORS LP | 555,216 | 290,217 | -264,999 | 0.01 | 0.00 | -0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 164,269 | 289,232 | +124,963 | 0.00 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 657,978 | 279,883 | -378,095 | 0.18 | 0.04 | -0.13 | sell |
| BANK OF AMERICA CORP /DE/ | 446,669 | 278,594 | -168,075 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 264,744 | 271,227 | +6,483 | 0.01 | 0.00 | -0.00 | buy |
| General Equity Holdings LP | 230,000 | 270,000 | +40,000 | 3.39 | 2.85 | -0.53 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 163,340 | 259,910 | +96,570 | 0.01 | 0.01 | -0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 29,263 | 246,034 | +216,771 | 0.01 | 0.03 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 240,560 | 243,160 | +2,600 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 58,353 | 231,059 | +172,706 | 0.00 | 0.00 | +0.00 | buy |
| BOSUN ASSET MANAGEMENT, LLC | 262,563 | 219,687 | -42,876 | 2.68 | 1.33 | -1.36 | sell |
| Russell Investments Group, Ltd. | 132,753 | 216,782 | +84,029 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 811,571 | 214,026 | -597,545 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 44,494 | 212,508 | +168,014 | 0.01 | 0.03 | +0.02 | buy |
| ROYAL BANK OF CANADA | 45,171 | 207,445 | +162,274 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 208,933 | 206,771 | -2,162 | 0.01 | 0.01 | -0.00 | sell |
| Squarepoint Ops LLC | 61,367 | 206,098 | +144,731 | 0.00 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 232,338 | 205,875 | -26,463 | 0.01 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 330,710 | 204,590 | -126,120 | 0.01 | 0.00 | -0.01 | sell |
| Scion Asset Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 3.47 | +3.47 | buy |
| PANAGORA ASSET MANAGEMENT INC | 237,550 | 194,956 | -42,594 | 0.02 | 0.01 | -0.01 | sell |
| DnB Asset Management AS | 0 | 194,840 | +194,840 | 0.00 | 0.01 | +0.01 | buy |
| ExodusPoint Capital Management, LP | 0 | 190,150 | +190,150 | 0.00 | 0.03 | +0.03 | buy |
| Legal & General Group Plc | 182,727 | 189,617 | +6,890 | 0.00 | 0.00 | -0.00 | buy |
| Lingotto Investment Management LLP | 0 | 189,200 | +189,200 | 0.00 | 0.07 | +0.07 | buy |
| 12 West Capital Management LP | 186,855 | 186,855 | 0 | 0.41 | 0.26 | -0.14 | hold |
| ALGERT GLOBAL LLC | 369,685 | 176,296 | -193,389 | 0.21 | 0.06 | -0.16 | sell |
| SkyView Investment Advisors, LLC | 0 | 173,876 | +173,876 | 0.00 | 0.37 | +0.37 | buy |
| DEUTSCHE BANK AG\ | 113,845 | 172,127 | +58,282 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 1,175,100 | 168,700 | -1,006,400 | 0.06 | 0.01 | -0.05 | sell |
| CITIGROUP INC | 146,776 | 168,042 | +21,266 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 34,313 | 157,065 | +122,752 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 155,055 | 156,901 | +1,846 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 151,589 | 154,365 | +2,776 | 0.00 | 0.00 | -0.00 | buy |
| OneDigital Investment Advisors LLC | 0 | 151,680 | +151,680 | 0.00 | 0.02 | +0.02 | buy |